Effects of folate treatment and homocysteine lowering on resistance vessel reactivity in atherosclerotic subjects

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 1, 2002, Pages 158-162

  Stanger, Olaf ^a,b   Semmelrock, Hans Juergen ^b   Wonisch, Willibald ^a   Bös, Ursula ^b   Pabst, Edmund ^b   Wascher, Thomas C ^a  

^a Department of Surgery   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID ANTAGONIST; HOMOCYSTEINE;

ADULT; ANGIOGRAPHY; ANTIOXIDANT ACTIVITY; ARM BLOOD FLOW; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CROSSOVER PROCEDURE; DISEASE ASSOCIATION; DRUG BLOOD LEVEL; DRUG EFFECT; HUMAN; HYPEREMIA; HYPERHOMOCYSTEINEMIA; HYPERTENSION; MALE; PLETHYSMOGRAPHY; PRIORITY JOURNAL; RESISTANCE BLOOD VESSEL; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM; VEIN OCCLUSION; VITAMIN BLOOD LEVEL;

ARTERIOSCLEROSIS; BLOOD FLOW VELOCITY; CHOLESTEROL; CORONARY DISEASE; CROSS-OVER STUDIES; FOLIC ACID; FOREARM; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; PLACEBOS; REGIONAL BLOOD FLOW; TRIGLYCERIDES; VASCULAR RESISTANCE; VITAMIN B 12;

EID: 0036784521     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.036715     Document Type: Article

References (35)

1. Anderson JL, Muhlestein JB, Horne BD, Carlquist JF, Bair TL, Madsen TE, and Pearsson RR (2000) Plasma homocysteine predicts mortality independently of traditional risk factors and C-reactive protein in patients with angiographically defined coronary artery disease. Circulation 102:1227-1232.
2. Anderson TJ, Uehata A, Gerhard MD, Meredith IT, Knab S, Delagrange D, man EH, Ganz P, Creager MA, and Yeung AC (1995) Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 26:1235-1241.
3. Araki A and Sako Y (1987) Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 422:43-52.
4. Bellamy MF, McDowell IF, Ramsey MW, Brownlee M, Bones C, Newcombe RG, and Lewis MJ (1998) Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation 98:1848-1852.
5. Boushey CJ, Beresford SAA, Omenn GS, and Motulsky AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. J Am Med Assoc 274:1049-1057.
6. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, and Deanfield JE (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk for atherosclerosis. Lancet 340:1111-1115.
7. Chambers JC, McGregor A, Jean-Marie J, Obeid OA, and Kooner JS (1999a) Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia. An effect reversible with vitamin C therapy. Circulation 99:1156-1160.
8. Chambers JC, Obeid OA, and Kooner JS (1999b) Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects. Arterioscler Thromb Vasc Biol 19:2922-2927.
9. Chambers JC, Ueland PM, Obeid OA, Wrigley J, Refsum H, and Kooner JS (2000) Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine. Circulation 102: 2479-2483.
10. Chillian W, Eastham C, and Marcus M (1986) Microvascular distribution of coronary vascular resistance in beating left ventricle. Am J Physiol 251:779-786.
11. Clarke RC and the Homocysteine Lowering Trialists' Collaboration (1998) Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials. Br Med J 316:894-898.
12. Harker LA, Harlan JM, and Ross R (1983) Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons. Circ Res 53:731-739.
13. Hasdai D, Gibbons RJ, Holmes DR, Higano ST, and Lerman A (1997) Coronary endothelial function in humans is associated with myocardial perfusion defects. Circulation 96:3390-3395.
14. Iwatsubo H, Nagano M, Sakai T, Kumamoto K, Morita R, Higaki J, Ogihara T, and Hata T (1997) Converting enzyme inhibitor improves forearm reactive hyperaemia in essential hypertension. Hypertension 29:286-290.
15. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, and Luscher TF (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91:1314-1319.
16. Kanani PM, Sinkey CA, Browning RL, Allaman M, Knapp HR, and Haynes WG (1999) Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation 100:1161-1168.
17. Kang SS, Wong PWK, and Malinow MR (1992) Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu Rev Nutr 12:279-298.
18. Loscalzo J (1996) The oxidant stress of hyperhomocyst(e)inemia. J Clin Investig 98:5-7.
19. Neunteufl T, Katzenschlager R, Hassan A, Klaar U, Schwarzacher S, Glogar D, Bauer P, and Weidinger F (1997) Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Atherosclerosis 129:111-118.
20. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, and Vollset SE (1997) Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337:230-236.
21. Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (Lond) 362:801-809.
22. Tawakol A, Omland T, Gerhard M, Wu JT, and Creager MA (1997) Hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 95:1119-1121.
23. Ubbink JB, Hayward-Vermaak WJ, and Bissbort S (1991) Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr 565:441-446.
24. Ubbink JB, Vermaak WJH, van der Merwe A, and Becker PJ (1993) Vitamin B-12, vitamin B-6 and folate nutritional status in men with hyperhomocysteinemia. Am J Clin Nutr 57:47-53.
25. Ueland PM and Refsum H (1989) Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease and drug therapy. J Lab Clin Med 114:473-501.
26. Upchurch GR, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF, and Loscalzo J (1997) Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem 272:17012-17017.
27. Verhaar MC, Wever R, Kastelein J, van Dam T, Koomans HA, and Rabelink TJ (1998) 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 97:237-241.
28. Vester B and Rasmussen K (1991) High-performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur J Clin Chem Clin Biochem 29:549-554.
29. Wall RT, Harlan JM, Harker LA, and Striker GE (1980) Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res 18:113-121.
30. Wascher TC, Bammer R, Stollberger R, Bahadori B, Wallner S, and Toplak H (1998) Forearm composition contributes to differences in reactive hyperaemia between healthy men and women. Eur J Clin Investig 28:243-248.
31. Wilmink HW, Stroes ES, Erkelens WD, Gerritsen WB, Wever R, Banga JD, and Rabelink TJ (2000) Influence of folic acid on postprandial endothelial dysfunction. Arterioscler Thromb Vasc Biol 20:185-188.
32. Woo KS, Chook P, Lolin YI, Cheung AS, Chan LT, Sun YY, Sanderson JE, Metreweli C, and Celermajer DS (1997) Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation 96:2542-2544.
33. Woo KS, Chook P, Lolin YI, Sanderson JE, Metreweli C, and Celermajer DS (1999) Folic acid improves arterial endothelial function in adults with hyperhomocysteinemia. J Am Coll Cardiol 34:2002-2006.
34. Zeiher A, Drexler H, Wolletschläger H, and Just H (1991) Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different stages of early coronary atherosclerosis. Circulation 83:391-401.
35. Zeiher AM, Krause T, Schächinger V, Minners J, and Moser E (1995) Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. Circulation 91:2345-2352.