Folding and stretching in a Go-like model of titin

Proteins: Structure, Function and Genetics

Volumn 49, Issue 1, 2002, Pages 114-124

  Cieplak, Marek ^a,b   Hoang, Trinh Xuan ^c   Robbins, Mark O ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b INSTITUTE OF PHYSICS   (Poland)

^c SISSA   (Italy)

Author keywords

Atomic force microscopy; Go model; Mechanical stretching of proteins; Molecular dynamics; Protein folding; Titin

Indexed keywords

CONNECTIN;

ARTICLE; ATOM; ATOMIC FORCE MICROSCOPY; CALCULATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN STRUCTURE; SIMULATION;

ANIMALS; COMPUTER SIMULATION; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUSCLE PROTEINS; PROTEIN FOLDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; STRESS, MECHANICAL; TEMPERATURE;

JONES;

EID: 0036783398     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10087     Document Type: Article

References (42)

1. A regular pattern of 2 types of 100-residue motif in the sequence of titin
2. Immunoglobulin-like modules from titin I-band: Extensible components of muscle elasticity
3. Stretching single protein molecules: Titin is a weird spring
4. Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation
5. Titins-giant proteins in charge of muscle ultrastructure and elasticity
6. Towards a molecular understanding of the elasticity of titin
7. Nonuniform elasticity of titin in cardiac myocytes: A study using immunoelectron microscopy and cellular mechanics
8. Elasticity and unfolding of single molecules of the giant muscle protein titin
9. Foldingunfolding in single titin molecules characterized with laser tweezers
10. Reversible unfolding of individual titin immunoglobulin domains by AFM
11. Mechanical unfolding intermediates in titin modules
12. Mechanical and chemical unfolding of a single protein: A comparison
13. Stepwise unfolding of titin under force-clamp atomic force microscopy
14. Single protein misfolding events captured by atomic force microscopy
15. Steered molecular dynamics simulation of conformational changes of immunoglobulin domain 127 interprete atomic force microscopy observations
16. Forced unfolding of fibronectin type 3 modules: An analysis by biased molecular dynamics simulations
17. Unfolding proteins by external forces and temperature: The importance of topology and energetics
18. Stretching single-domain proteins: Phase diagram and kinetics of force-induced unfolding
19. Native topology determines forceinduced unfolding pathways in globular proteins
20. Protein folding kinetics: Time scales, pathways and energy landscapes in terms of sequence-dependent properties
21. Noninteracting local-structure model of folding and unfolding transition in globular proteins. II. Application to two-dimensional lattice proteins
22. Go-ing for the prediction of protein folding mechanism
23. Protein structures and optimal folding from a geometrical variational principle
24. Role of secondary motifs in fast folding polymers: A dynamical variational principle
25. Molecular dynamics of folding of secondary structures in Go-like models of proteins
26. Sequencing of folding events in Go-like proteins
27. Kinetics non-optimality and vibrational stability of proteins
28. The Protein Data Bank: A computer-based archival file for macromolecular structures
29. Molecular dynamics simulation for polymers in the presence of a heat bath
30. Viscosity dependence of the folding rates of proteins
31. Kinetics and thermodynamics of folding in model proteins
32. A criterion that determines the foldability of proteins
33. Local interactions dominate folding in a simple protein model
34. Matching speed and locality
35. Contact order, transition state placement and the refolding rates of single domain proteins
36. Topology, stability, sequence, and length: Defining the determinants of two-state protein folding kinetics
37. Stretching lattice models of protein folding
38. Titin folding energy and elasticity
39. Reversible unfolding of fibronectin type-III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin
40. The study of protein mechanics with atomic force microscopy
41. Molecular mechanistic origin of the toughness of natural adhesives, fibres and compsites