Optical resolution by preferential crystallization of (RS)-2-benzoylamino- 2-benzyl-3-hydroxypropanoic acid and its use in synthesizing optically active 2-amino-2-methyl-3-phenylpropanoic acid

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 10, 2002, Pages 1362-1366

  Shiraiwa, Tadashi ^a   Suzuki, Masahiro ^a   Sakai, Yoshio ^a   Nagasawa, Hisashi ^a   Takatani, Kazuhiro ^a   Noshi, Daisuke ^a   Yamanashi, Kenji ^a  

^a KANSAI UNIVERSITY   (Japan)

Author keywords

methylphenylalanine; N benzoyl benzylserine; Optical resolution; Preferential crystallization

Indexed keywords

2 AMINO 2 METHYL 3 PHENYLPROPANOIC ACID; 2 BENZOYLAMINO 2 BENZYL 3 HYDROXYPROPANOIC ACID; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; PHENYLPROPIONIC ACID DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CRYSTALLIZATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROMETRY; MELTING POINT; OPTICAL RESOLUTION; PURIFICATION; RACEMIC MIXTURE; REDUCTION; ROOM TEMPERATURE; STRUCTURE ANALYSIS; TOSYLATION; CHEMISTRY; OPTICAL ROTATION; SYNTHESIS;

CRYSTALLIZATION; OPTICAL ROTATION; PHENYLPROPIONATES;

EID: 0036780365     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.1362     Document Type: Article

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11. (RS)-6 obtained by refluxing for 20 min: Yield, 4.09 g (72.5%); mp 190-192°C. (RS)-6 obtained by refluxing for 30 min: Yield, 3.93 g (65.9%); mp 191-193°C.