In patients with deep-vein thrombosis elevated levels of factor VIII correlate only with von Willebrand factor but not other endothelial cell-derived coagulation and fibrinolysis proteins

Blood Coagulation and Fibrinolysis

Volumn 13, Issue 7, 2002, Pages 577-581

  Bombeli, Thomas ^a   Jutzi, M ^a   De Conno, E ^a   Seifert, B ^a   Fehr, J ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Factor VIII; Plasminogen activator inhibitor; Thrombomodulin; Thrombosis,; Von Willebrand factor

Indexed keywords

BLOOD CLOTTING FACTOR 8; PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBOMODULIN; TISSUE PLASMINOGEN ACTIVATOR; VON WILLEBRAND FACTOR; BIOLOGICAL MARKER; PLASMA PROTEIN;

ADULT; ARTICLE; BLOOD CLOTTING; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBRINOLYSIS; HEMATOLOGICAL PARAMETERS; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THROMBOEMBOLISM; VASCULAR ENDOTHELIUM; BLOOD; CASE CONTROL STUDY; MIDDLE AGED; MULTIVARIATE ANALYSIS; SECRETION; VEIN THROMBOSIS;

ADULT; BIOLOGICAL MARKERS; BLOOD COAGULATION; BLOOD PROTEINS; CASE-CONTROL STUDIES; ENDOTHELIUM, VASCULAR; FACTOR VIII; FEMALE; FIBRINOLYSIS; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; VENOUS THROMBOSIS; VON WILLEBRAND FACTOR;

EID: 0036776063     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-200210000-00001     Document Type: Article

References (18)

1. Koster T, Blann AD, Briet E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet 1995; 345: 152-155.
2. O'Donnell J, Tuddenham EG, Manning RA, Kemball-Cook G, Johnson D, Laffan M. High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: Role of increased synthesis and relationship to the acute phase reaction. Thromb Haemost 1997; 77: 825-828.
3. Kamphuisen PW, Houwing-Duistermaat JJ, van Houwelingen JC, Eikenboom JCJ, Bertina RM, Rosendaal FR. Familial clustering of factor VIII and von Willebrand factor levels. Thromb Haemost 1998; 79: 323-327.
4. Mansvelt EPG, Laffan M, McVey JH, Tuddenham EDG. Analysis of the F8 gene in individuals with high plasma factor VIII:C levels and associated venous thrombosis. Thromb Haemost 1998; 80: 561-565.
5. Kamphuisen PW, Eikenboom JCJ, Vos HL, Pablo R, Sturk A, Bertina RM, Rosendaal FR. Increased levels of factor VIII and fibrinogen in patients with venous thrombosis are not caused by acute phase reactions. Thromb Haemost 1999; 81: 680-683.
6. Kraaijenhagen RA, in t' Anker PS, Koopman MMW, Reitsma PH, Prins MH, van den Ende A, Büller HR. High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism. Thromb Haemost 2000; 83: 5-9.
7. Kamphuisen PW, Lensen R, Houwing-Duistermaat JJ, Eikenboom JCJ, Harvey M, Bertina RM, Rosendaal FR. Heritability of elevated factor VIII antigen levels in factor V Leiden families with thrombophilia. Br J Haematol 2000; 109: 519-522.
8. O'Donnell J, Mumford AD, Manning RA, Laffan M. Elevation of FVIII:C in venous thromboembolism is persistent and independent of the acute phase response. Thromb Haemost 2000; 83: 10-13.
9. Kamphuisen PW, Eikenboom JCJ, Bertina RM. Elevated factor VIII levels and the risk of thrombosis. Arterioscler Thromb Vasc Biol 2001; 21: 731-734.
10. Vlot AJV, Koppelman J, Bouma BN, Sixma JJ. Factor VIII and von Willebrand Factor. Thromb Haemost 1998; 79: 456-465.
11. Wion KL, Kelly D, Summerfield JA, Tuddenham EG, Lawn RM. Distribution of factor VIII mRNA and antigen in human liver and other tissues. Nature 1985; 317: 726-729.
12. Bombeli T, Mueller M, Haeberli A. Anticoagulant properties of the vascular endothelium. Thromb Haemost 1997; 77: 408-423.
13. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmermann GA, McEver RP, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998; 91: 3527-3561.
14. Giddings JC, Coles P, Williams BD. Comparison of thrombomodulin and von Willebrand factor antigen in human plasma in various diseases. Thromb Haemost 1989; 62: 333-338.
15. Wiman B. Plasminogen activator inhibitor 1 (PAI-1) in plasma: Its role in thrombotic disease. Thromb Haemost 1995; 74: 71-76.
16. Jick H, Slone D, Weserholm B. Venous thromboembolic disease and ABO blood type. Lancet 1969; 1: 539-542.
17. Bowen DJ, MacLean RM, Pellard S, Collins PW. High concentration of coagulation factor VIII and thrombosis: Is the factor VIII-binding domain of von Willebrand factor implicated? Br J Haematol 2001; 113: 655-657
18. Kamphuisen PW, Eikenboom JC, Rosendaal FR, Koster T, Blann AD, Vos HL, Bertina RM. High factor VIII antigen levels increase the risk of venous thrombosis but are not associated with polymorphisms in the von Willebrand factor and factor VIII gene. Br J Haematol 2001; 115: 156-158.