The effects of short-term medroxyprogesterone acetate and micronized progesterone on glucose metabolism and lipid profiles in patients with polycystic ovary syndrome: A prospective randomized study

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 10, 2002, Pages 4536-4540

  Bagis, Tayfun ^a,c   Gokcel, Adnan ^a   Zeyneloglu, Hulusi Bulent ^b   Tarim, Ebru ^c   Kilicdag, Esra Bulgan ^a   Haydardedeoglu, Bulent ^b  

^a BASKENT UNIVERSITY   (Turkey)

^b Endocrinology and Metabolism Division   (Turkey)

^c Obstetrics and Gynecology Department   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; MEDROXYPROGESTERONE ACETATE; PROGESTERONE; TESTOSTERONE;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; FEMALE; GLUCOSE METABOLISM; HOMEOSTASIS; HORMONAL THERAPY; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; ORAL GLUCOSE TOLERANCE TEST; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; TESTOSTERONE BLOOD LEVEL; TREATMENT OUTCOME;

ADMINISTRATION, INTRAVAGINAL; ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL, LDL; FEMALE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; LIPIDS; LIPOPROTEIN(A); LUTEINIZING HORMONE; MEDROXYPROGESTERONE 17-ACETATE; POLYCYSTIC OVARY SYNDROME; PROGESTERONE; PROSPECTIVE STUDIES; TESTOSTERONE;

FALLOPIA;

EID: 0036775184     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2002-020294     Document Type: Article

References (26)

1. Burghen GA, Givens JR, Kitabchi AE 1980 Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J Clin Endocrinol Metab 50:113-116
2. Shoupe D, Kumar DD, Lobo RA 1983 Insulin resistance in polycystic ovary syndrome. Am J Obstet Gynecol 147:588-592
3. Dunaif A, Graf M, Mandeli J, Laumas V, Dobrjansky A 1987 Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance and/or hyperinsulinemia. J Clin Endocrinol Metab 65:499-507
4. Dunaif A, Futterweit W, Segal KR, Dobrjansky A 1989 Profound peripheral insulin resistance, independent of obesity, in the polycystic ovary syndrome. Diabetes 38:1165-1174
5. Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A, Licholai T 1992 Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 41:1257-1266
6. Ehrmann DA, Sturis J, Byrne MM, Karrison T, Rosenfield RL, Polonksy KS 1995 Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. J Clin Invest 96:520-527
7. Dunaif A, Xia J, Book C, Schenker E, Tang Z 1995 Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle: A potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest 96:801-810
8. Mikola M, Hiilesmaa V, Halttunen M, Suhonen L, Tiitinen A 2001 Obstetric outcome in women with polycystic ovarian syndrome. Hum Reprod 16:226-229
9. Conn JJ, Jacobs HS, Conway GS 2000 The prevalence of polycystic ovaries in women with type 2 diabetes mellitus. Clin Endocrinol (Oxf) 52:81-86
10. Cefalu WT, Wagner JD, Bell-Farrow AD, Wang ZO, Adams MR, Toffolo G, Cobelli C 1994 The effects of hormonal replacement therapy on insulin sensitivity in surgically postmenopausal cynomolgus monkeys (Macaca fascicularis) Am J Obstet Gynecol 171:440-445
11. Godsland IF, Walton C, Felton C, Proudler A, Patel A, Wynn V 1992 Insulin resistance, secretion, and metabolism in users of oral contraceptives. J Clin Endocrinol Metab 74:64-70
12. Elkind-Hirsch KE, Sherman LD, Malinak R 1993 Hormone replacement therapy alters insulin sensitivity in young women with premature ovarian failure. J Clin Endocrinol Metab 76:472-475
13. Bergman RN, Prager R, Volund A, Olefsky JM 1987 Equivalence of the insulin sensitivity in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest 79:790-800
14. Ferrannini E, Mari A 1998 How to measure insulin sensitivity. J Hypertens 16:895-906
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RI 1985 Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 28:412-419
16. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ 2000 Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402-2410
17. Lindheim SR, Duffy DM, Kojima T, Vijod MA, Stanczyk FZ, Lobo RA 1994 The route of administration influences the effect of estrogen on insulin sensitivity in postmenopausal women. Fertil Steril 62:1176-1180
18. The Writing Group for the PEPI Trial 1995 Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) trial. JAMA 273:199-208
19. Fiad TM, Cunningham SK, McKenna TJ 1996 Role of progesterone deficiency in the development of luteinizing hormone and androgen abnormalities in polycystic ovary syndrome. Eur J Endocrinol 135:335-339
20. Anttila L, Koskinen P, Erkkola R, Irjala K, Ruutiainen K 1994 Serum testosterone, androstenedione and luteinizing hormone levels after short-term medroxyprogesterone acetate treatment in women with polycystic ovarian disease. Acta Obstet Gynecol Scand 73:634-636
21. Wagner JD, Thomas MJ, Williams JK, Zhang L, Greaves KA, Cefalu WT 1998 Insulin sensitivity and cardiovascular risk factors in ovariectomized monkeys with estradiol alone or combined with nomegestrol acetate. J Clin Endocrinol Metab 83:896-901
22. Laakso M, Sarlund H, Mykkanen L 1990 Insulin resistance is associated with lipid and lipoprotein abnormalities in subjects with varying degrees of glucose tolerance. Arteriosclerosis 10:223-231
23. Ferrannini E, Haffner SM, Mitchell BD, Stern MP 1991 Hyperinsulinaemia: The key feature of a cardiovascular and metabolic syndrome. Diabetologia 34:416-422
24. Despres JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, Lupien PJ 1996 Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 334:952-957
25. Escobar-Morreale HF, Lasuncion MA, Sancho J 2000 Treatment of hirsutism with ethinyl estradiol-desogestrel contraceptive pills has beneficial effects on the lipid profile and improves insulin sensitivity. Fertil Steril 74:816-819
26. Balasch J, Fabregues F, Ordi J, Creus M, Penarrubia J, Casamitjana R, Manau D, Vanrell JA 1996 Further data favoring the hypothesis of the uterine firstpass effect of vaginally administered micronized progesterone. Gynecol Endocrinol 10:421-426