Effects of inhaled plasminogen activator on the balance between coagulation and fibrinolysis in traumatized pigs

Blood Coagulation and Fibrinolysis

Volumn 13, Issue 7, 2002, Pages 591-601

  Münster, Anna Marie Bloch ^a   Rasmussen, L ^a   Sidelmann, J ^a   Jensen, J Ingemann ^a   Bech, B ^a   Gram, J ^a  

^a ESBJERG HOSPITAL   (Denmark)

Author keywords

Animal study; Fibrinolytic therapy; Inhalation; Severe trauma

Indexed keywords

FIBRIN; PLACEBO; PLASMIN INHIBITOR; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; SARUPLASE; SODIUM CHLORIDE; ANTIFIBRINOLYTIC AGENT; UROKINASE;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; BLOOD SAMPLING; CONTROLLED STUDY; FIBRINOLYSIS; FIBRINOLYTIC THERAPY; HEMODYNAMIC PARAMETERS; LOWER RESPIRATORY TRACT; LUNG ARTERY PRESSURE; LUNG INJURY; LUNG LAVAGE; LUNG WEDGE PRESSURE; NEBULIZATION; NEBULIZER; NONHUMAN; PLASMA; PRIORITY JOURNAL; SWINE; TREATMENT OUTCOME; ANIMAL; DRUG EFFECT; DRUG SCREENING; INHALATIONAL DRUG ADMINISTRATION; INJURY; LUNG ALVEOLUS; PATHOLOGY;

ADMINISTRATION, INHALATION; ANIMALS; ANTIFIBRINOLYTIC AGENTS; BLOOD COAGULATION; BRONCHOALVEOLAR LAVAGE FLUID; DRUG EVALUATION, PRECLINICAL; FIBRINOLYSIS; PLACEBOS; PULMONARY ALVEOLI; RESPIRATORY DISTRESS SYNDROME, ADULT; SWINE; THROMBOLYTIC THERAPY; URINARY PLASMINOGEN ACTIVATOR; WOUNDS AND INJURIES;

EID: 0036774339     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-200210000-00003     Document Type: Article

References (33)

1. Idell S, James KK, Levin EG, Schwartz BS, Manchanda N, Maunder RJ, et al. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest 1989; 84: 695-705.
2. Bertozzi P, Astedt B, Zenzius L, Lynch K, LeMaire F, Zapol W, Chapman HA Jr. Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. N Engl J Med 1990; 322: 890-897.
3. Idell S, Koenig KB, Fair DS, Martin TR, McLarty J, Maunder RJ. Serial abnormalities of fibrin turnover in evolving adult respiratory distress syndrome. Am J Physiol 1991; 261: L240-L248.
4. Olman MA, Mackman N, Gladson CL, Moser KM, Loskutoff DJ. Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse. J Clin Invest 1995; 96: 1621-1630.
5. Idell S, Peters J, James KK, Fair DS, Coalson JJ. Local abnormalities of coagulation and fibrinolytic pathways that promote alveolar fibrin deposition in the lungs of baboons with diffuse alveolar damage. J Clin Invest 1989; 84: 181-193.
6. Sitrin RG, Brubaker PG, Fantone JC. Tissue fibrin deposition during acute lung injury in rabbits and its relationship to local expression of procoagulant and fibrinolytic activities. Am Rev Respir Dis 1987; 135: 930-936.
7. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al. Report of the American European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149: 818-824.
8. Suchyta MR, Clemmer TP, Elliotte LG, Orme JF Jr, Weaver KL. The adult respiratory distress syndrome. A report of survival and modifying factors. Chest 1992; 101: 1074-1079.
9. Milberg JA, Davis DR, Steinberg KP, Hudson LD. Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993. JAMA 1995; 273: 306-309.
10. Abel SJC, Finney SJ, Brett SJ, Keogh BF, Morgan CJ, Evans TW. Reduced mortality in association with the acute respiratory distress syndrome (ARDS). Thorax 1998; 53: 292-294.
11. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308.
12. Martin C, Papazian L, Payan M-J, Saux P, Gouin F. Pulmonary fibrosis correlates with outcome in adult respiratory distress syndrome. A study in mechanically ventilated patients. Chest 1995; 107: 196-200.
13. Gram J, Mtinster A-M, Dilling-Hansen B, Lavassani HA, Lahoz AX, Jespersen J. Inhalation/intravenous recombinant tissue plasminogen activator and inhaled heparin in a patient with acute respiratory distress syndrome. Short communication. Fibrinolysis Proteolysis 1999; 13: 209-212.
14. Münster A-MB, Bendstrup E, Jensen JI, Gram J. Jet and ultrasonic nebulization of single chain urokinase plasminogen activator (scu-PA). J Aerosol Med 2000; 13: 325-333.
15. Münster AM B, Ingemann Jensen J, Bech B, Gram J. Activation of blood coagulation in pigs following lower limb gunshot trauma. Blood Coagul Fibrinolysis 2001; 12: 477-485.
16. Lissau B. Good laboratory practice. In: Svendsen P, Hau J (editors): Handbook of Laboratory Animal Science. London: CRC Press; 1994. pp. 37-40.
17. Kjeldgaard NO, Ploug J. Urokinase an activator of plasminogen from human urine. II. Mechanism of plasminogen activation. Biochim Biophys Acta 1957; 24: 283-289.
18. Alkjaersig N, Fletcher AP, Sherry S. The activation of human plasminogen. II. A kinetic study of activation with trypsin, urokinase, and streptokinase. J Biol Chem 1958; 233: 86-90.
19. Levi M, ten Cate JW, Dooijewaard G, Sturk A, Brommer EJP, Agnelli G. DDAVP induces systemic release of urokinase-type plasminogen activator. Thromb Haemost 1989; 62: 686-689.
20. Binnema DJ, van Iersel JJL, Dooijewaard G. Quantitation of urokinase antigen in plasma and culture media by use of an ELISA. Thromb Res 1986; 43: 569-577.
21. Jespersen J, Gram J, Astrup T. The autodigestion of human plasmin follows a bimolecular mode of reaction subject to product inhibition. Thromb Res 1986; 41: 395-404.
22. Barazzone C, Belin D, Piguet P-F, Vassalli J-D, Sappino A-P. Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury. J Clin Invest 1996; 98: 2666-2673.
23. Eitzman DT, McCoy RD, Zheng X, Fay WP, Shen T, Ginsburg D, Simon RH. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 1996; 97: 232-237.
24. Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, et al. Physiological consequences of loss of plasminogen activator gene function in mice. Nature 1994; 368: 419-424.
25. Lardot CG, Huaux FA, Broeckaert FR, Declerck PJ, Delos M, Fubini B, Lison DF. Role of urokinase in the fibrogenic response of the lung to mineral particles. Am J Respir Crit Care Med 1998; 157: 617-628.
26. Hardaway RM, Williams CH, Marvasti M, Farias M, Tseng A, Pinon I, et al. Prevention of adult respiratory distress syndrome with plasminogen activator in pigs. Crit Care Med 1990; 18: 1413-1418.
27. Leroux B, Rose J-P, Potron G, Grun G, Droulle C, Mesmin F, Gomes H. Traitement de la maladie des membranes hyalines par l'association plasminogèneurokinase. Nouv Presse Méd 1976; 5: 699-702.
28. Hart DA, Whidden P, Green F, Henkin J, Woods DE. Partial reversal of established bleomycin-induced pulmonary fibrosis by rh-urokinase in a rat model. Clin Invest Med 1994; 17: 69-76.
29. Chapman HA Jr, Lee Stone O, Vavrin Z. Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation. J Clin Invest 1984; 73: 806-815.
30. Suter PM, Suter S, Girardin E, Roux-Lombard P, Grau GE, Dayer J-M. High broncholalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am Rev Respir Dis 1992; 145: 1016-1022.
31. Delclaux D, d'Ortho M-P, Delacourt C, Lebargy F, Brun-Buisson C, Brochard L, et al. Gelatinases in epithelial lining fluid of patients with adult respiratory distress syndrome. Am J Physiol 1997; 272: L442-L451.
32. Lennquist S, Jansson I, Lovén L. A new experimental model for studies on the respiratory distress syndrome after standardized trauma. Acta Chir Scand/Suppl 1985; 522: 291-313.
33. Jansson I, Eriksson R, Jorfeldt L, Liljedahl S-O, Lovén L, Rammer L, Lennquist S. Post-traumatic respiratory failure after high velocity missile injury of the limb in anaesthetized pigs. Acta Chir Scand/Suppl 1982; 508: 345-349.