The carcinogenic response of Tsc2 mutant long-evans (Eker) rats to a mixture of drinking water disinfection by-products was less than additive

Toxicological Sciences

Volumn 69, Issue 2, 2002, Pages 322-331

  Hooth, Michelle J ^a,c   McDorman, Kevin S ^b   Hester, Susan D ^a   George, Michael H ^a   Brooks, Lance R ^a   Swank, Adam E ^a   Wolf, Douglas C ^a,d  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Disinfection by products; Drinking water; Eker rat; Kidney; Mixtures; Renal

Indexed keywords

BROMODICHLOROMETHANE; CHEMICAL MUTAGEN; CHLOROFORM; DRINKING WATER; FURANONE DERIVATIVE; POTASSIUM BROMATE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHEMICAL CARCINOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISINFECTION; DOSE RESPONSE; FAMILIAL CANCER; FEMALE; FLUID INTAKE; GENE MUTATION; KIDNEY ADENOMA; KIDNEY CANCER; KIDNEY CARCINOMA; KIDNEY INJURY; MALE; MICROSCOPY; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; SPLEEN TUMOR; UTERUS TUMOR;

ADENOMA; ANIMALS; CARCINOGENS; CARCINOMA; DISINFECTANTS; DISINFECTION; DRINKING; FEMALE; KIDNEY NEOPLASMS; MALE; NEOPLASMS; ORGAN SIZE; RATS; RATS, LONG-EVANS; REPRESSOR PROTEINS; SEX CHARACTERISTICS; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS; WATER POLLUTANTS, CHEMICAL; WATER SUPPLY;

ANIMALIA; RODENTIA;

EID: 0036772789     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/69.2.322     Document Type: Article

References (41)

1. American Public Health Association, American Water Works Association, and Water Environment Federation. (1998). Method 6232B. In Standard Methods for the Examination of Water and Wastewater, 20th ed. American Public Health Association, Washington, D.C.
2. Carpy, S. A., Kobel, W., and Doe, J. (2000). Health risk of low-dose pesticides mixtures: A review of the 1985-1998 literature on combination toxicology and health risk assessment. J. Toxicol. Environ. Health B Crit. Rev. 3, 1-25.
3. Cavanagh, J. E., Weinber, H. S., Gold, A., Sangalah, R., Marbury, D., Glase, W. H., Collette, T. W., Richardson, S. D., and Thruston, A. D. (1992). Ozonation byproducts: Identification of bromohydrins from the ozonation of natural waters with enhanced bromide levels. Environ. Sci. Technol. 2, 1658-1662.
4. Coleman, W. E., and Munch, J. W. (1991). GC/MS analysis of Jefferson Parish, Louisiana, pilot plant water following alternate disinfection and XAD resin concentration, Report, January 18, 1991. U.S. EPA, RREL, EMSL, Cincinnati, OH.
5. Condie, L. W., Lauer, W. C., Wolfe, G. W., Czeh, E. T., and Burns J. M. (1994). Denver potable water reuse demonstration project: Comprehensive chronic rat study. Food Chem. Toxicol. 32, 1021-1030.
6. 1 mice and F344/N rats. Toxicol. Pathol. 26, 587-594.
7. DeMarini, D. M. (1998). Mutation spectra of complex mixtures. Mutat. Res. 411, 11-8.
8. De Vriese, A., Vanholder, R., and Lameire, N. (1997). Severe acute renal failure due to bromate intoxication: Report of a case and discussion of management guidelines based on a review of the literature. Nephrol. Dial. Transplant. 12, 204-209.
9. Dunnick, J. K., Eustis, S. L., and Lilja, H. S. (1987). Bromodichloromethane, a trihalomethane that produces neoplasms in rodents. Cancer Res. 47, 5189-5193.
10. Elashoff, R. M., Fears, T. R., and Schneiderman, M. A. (1987). Statistical analysis of a carcinogen mixture experiment. I. Liver carcinogens. J. Natl. Cancer Inst. 79, 509-526.
11. 1 mice. Proc. Am. Assoc. Cancer Res. 40, 349 (Abstract).
12. 1 mice. Fundam. Appl. Toxicol. 13, 377-387.
13. Glaze, W. H. (1986). Reaction products of ozone: A review. Environ. Health Perspect. 69, 151-157.
14. Guengerich, F. P., Kim, D. H., and Iwasaki, M. (1991). Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4, 168-179.
15. 1 mice. Fundam. Appl. Toxicol. 5, 760-769.
16. Kobayashi, T., Hirayama, Y., Kobayashi E., Kubo, Y., and Hino, O. (1995). A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat. Genet. 9, 70-74.
17. Komulainen, H., Huuskonen, H., Kosma, V-M., Lötjönen, S., and Vartiainen, T. (1994). Toxic effects and excretion in urine of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a drinking water mutagen, after a single oral dose. Arch. Toxicol. 68, 398-400.
18. Komulainen, H., Kosma, V.-M., Vaittinen, S.-L., Vartiainen, T., Kaliste-Korhonen, E., Lötjönen, S., Tuominen, R. K., and Tuomisto J. (1997). Carcinogenicity of the drinking water mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in the rat. J. Natl. Cancer Inst. 89, 848-856.
19. Kronberg, L., and Vartiainen, T. (1988). Ames mutagenicity and concentration of the strong mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and of its geometric isomer (E)-2-chloro-3-(dichloromethyl)-4-oxobutenoic acid in chlorine-treated tap waters. Mutation Res. 206, 177-182.
20. Kurokawa, Y., Maekawa, A., Takahashi, M., and Hayashi, Y. (1990). Toxicity and carcinogenicity of potassium bromate: A new renal carcinogen. Environ. Health Perspect. 87, 309-335.
21. 1 mice. Environ. Mol. Mutagen. 23, 132-136.
22. Meier, J. R., Blazak, W. F., and Knohl, R. B. (1987). Mutagenic and clastogenic properties of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone: A potent bacterial mutagen in drinking water. Environ. Mol. Mutagen 10, 411-424.
23. Meier, J. R., DeAngelo, A. B., Daniel, F. B., Schenck, K. M., and Doerger, J. U. (1990). Genotoxic and carcinogenic properties of chlorinated furanones: Important by-products of water chlorination. Available from National Technical Information Service, Springfield, VA (NTIS/PB90-119223, 22).
24. Morimoto, K., and Koizumi, A. (1983). Trihalomethanes induce sister chromatid exchanges in human lymphocytes in vitro and mouse bone marrow cells in vivo. Environ. Res. 32, 72-79.
25. 1 mice. NTP TOX 35. National Toxicology Program, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health.
26. Nesnow, S., Mass, M. J., Ross, J. A., Galati, A. J., Lambert, G. R., Gennings, C., Carter, W. H., Jr., and Stoner, G. D. (1998). Lung tumorigenic interactions in strain A/J mice of five environmental polycyclic aromatic hydrocarbons. Environ. Health Perspect. 106(Suppl. 6), 1337-1346.
27. Ogawa, S., Hiroshi, K., Hanasaki, Y., and Fukui, S. (1993). Determination of the potent mutagen 3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-franone (MX) in water by gas chromatography with electron-capture detector. J. Chromatography 643, 221-226.
28. Pegram, R. A., Anderson, M. E., Warren, S. H., Ross, T. M., and Claxton, L. D. (1997). Glutathione S-transferase-mediated mutagenicity of trihalomethanes in Salmonella typhimurium: Contrasting results with bromodichloromethane off chloroform. Toxicol. Appl. Pharmacol. 144, 183-188.
29. 1 mice. Cancer Lett. 115, 15-23.
30. Reitz, R. H., Fox, T. R., and Quast, J. F. (1982). Mechanistic considerations for carcinogenic risk estimation: Chloroform. Environ. Health Perspect. 46, 163-168.
31. Richardson, S. D. (1998). Drinking water disinfection by-products. In Encyclopedia of Environmental Analysis and Remediation (R. A. Meyers, Ed.), pp. 1398-1421. Wiley, New York.
32. Rosenthal, S. L. (1987). A review of the mutagenicity of chloroform. Environ. Mol. Mutagen. 10, 211-226.
33. Simmons, J. E., Yang, R. S., Svendsgaard, D. J., Thompson, M. B., Seely, J. C., and McDonald, A. (1994). Toxicology studies of a chemical mixture of 25 groundwater contaminants: Hepatic and renal assessment, response to carbon tetrachloride challenge, and influence of treatment-induced water restriction. J. Toxicol. Environ. Health 43, 305-325.
34. Teuschler, L. K., Gennings, C., Stiteler, W. M., Hertzberg, R. C., Colman, J. T., Thiyagarajah, A., Lipscomb, J. C., Hartley, W. R., and Simmons, J. E. (2000). A multiple-purpose design approach to the evaluation of risks from mixtures of disinfection by-products. Drug Chem. Toxicol. 23, 307-321.
35. Thornton-Manning, J., Gao, P., Lilly, P. D., and Pegram, R. A. (1993). Acute bromodichloromethane toxicity in rats pretreated with cytochrome P450 inducers and inhibitors. Toxicologist 13, 361 (Abstract).
36. 3) carcinogenesis. Carcinogenesis 16, 593-597.
37. U.S. EPA (1996). Method 300.0, Part B. Determination of inorganic anions by ion chromatography. Reprints of EPA Methods for Chemical Analyses under the Information Collection Rule. Technical Report No. 814-B-96-006, Office of Groundwater and Drinking Water, Technical Support Division, Cincinnati, OH.
38. U.S. EPA. (2000). Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures. EPA/630/R-00/002, Risk Assessment Forum, Washington, DC.
39. Walker, C., Goldsworthy, T. L., Wolf, D. C., and Everitt, J. (1992). Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene. Science 255, 1693-1695.
40. Wolf, D. C., Goldsworthy, T. L., Donner, E. M., Harden, R., Fitzpatrick, B., and Everitt, J. I. (1998). Estrogen treatment enhances renal tumor development in Eker rats. Carcinogenesis 19, 2043-2047.
41. Yeung, R. S., Xiao, G.-H., Lin, F., Lee, W.-C., Testa, J. R., and Knudson, A. G. (1994). Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (Tsc2) gene. Proc. Natl. Acad. Sci. U.S.A. 91, 11413-11416.