High Prevalence of Anti-Glutamic Acid Decarboxylase (Anti-GAD) Antibodies in Employees at a Polychlorinated Biphenyl Production Factory

Archives of Environmental Health

Volumn 57, Issue 5, 2002, Pages 412-415

  Langer, Pavel ^a   Šeböková, Elena ^a   Klimeš, Iwar ^a   Tajtáková, Mária ^b   Guretzki, Hans Joachim ^c   Kočan, Anton ^d   Petrík, Ján ^d   Chovancová, Jana ^d   Drobná, Beáta ^d   Jursa, Stanislav ^d   Pavúk, Marián ^d   Trnovec, Tomáš ^d  

^a INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

^b P J car afárik University   (Slovakia)

^c BRAHMS Diagnostica GmbH   (Germany)

^d INST OF PREV AND CLINICAL MEDICINE   (Slovakia)

Author keywords

Anti gad; Anti tpo prevalence; Antibodies; Immunomodulation; Industrial pollution; Polychlorinated biphenyls

Indexed keywords

GLUTAMATE DECARBOXYLASE ANTIBODY; POLYCHLORINATED BIPHENYL; THYROID ANTIBODY;

ADULT; AGE; AGED; ARTICLE; CHEMICAL INDUSTRY; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HUMAN; IMMUNOMODULATION; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL EXPOSURE; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SLOVAKIA; STATISTICAL ANALYSIS;

EID: 0036771533     PISSN: 00039896     EISSN: None     Source Type: Journal    
DOI: 10.1080/00039890209601429     Document Type: Article

References (25)

1. Safe SH. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Cnt Rev Toxicol 1993; 24:87-149.
2. Kavlock RJ, Daston GP, DeRosa C, et al. Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop. Environ Health Perspect 1996; 104:15-40.
3. Kocan A, Petrik J, Drobna B, et al. Levels of PCBs and some organochlorine pesticides in the human population of selected areas of the Slovak Republic. I. Blood. Chemosphere 1994; 29: 2315-25.
4. Kocan A, Petrik J, Drobna B, et al. Environmental and Human Pollution in the Area Contaminated by Polychlorinated Biphenyls (in Slovak). Bratislava, Hungary: Institute of Preventive and Clinical Medicine, 1999; research report.
5. Langer P, TajtSkova M, Fodor G, et al. Increased thyroid volume and prevalence of thyroid disorders in an area heavily polluted by polychlorinated biphenyls. Eur J Endocrinol 1998; 39:402-06.
6. McCanlies E, O'Laery L, Foley TP, et a!. Hashimoto's thyroiditis and insulin-dependent diabetes mellitus: differences among individuals with and without abnormal thyroid function. J Clin Endocrinol Metab 1998; 83:1548-51.
7. Chang CC, Huang CN, Chuang I.M. Autoantibodies to thyroid peroxidase in patients with type I diabetes in Taiwan. Eur J Endocrinol 1998; 139:44-48.
8. Weetman AP. Autoimmunity in endocrinology. Exp Clin Endocrinol Diabetes 1999; 107(Suppl 3): S63-66.
9. Volpe R. The autoimmune endocrinopathies. Trends Endocrinol Metab 1997; 8:59-63.
10. Michielsen CPPC, van loveren H, Vos G. The role of the immune system in hexachlorobenzene-induced toxicity. Environ Health Perspect 1999; 107(Suppl 5):783-92.
11. Wiersinga WM. Environmental factors in autoimmune thyroid disease. Exp Clin Endocrinol Diabetes 1999; 107(Suppl 3): S67-S70.
12. Rao T, Richardson B. Environmentally induced autoimmune diseases: potential mechanisms. Environ Health Perspect 1999; 107 (Suppl 5):737-41.
13. Brucker-Davis F. Effects of environmental synthetic chemicals on thyroid function. Thyroid 1998; 8:827-56.
14. Kraine MR, Tisch RM. The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue. Environ Health Perspect 1999; 107(Suppl 5):777-82.
15. Heward J, Gough SCL. Genetic susceptibility to the development of autoimmune disease. Clin Sci (Colch) 1997; 93:479-91.
16. Bertazzi PA, Bernucci I, Brambilla G, et al. The Seveso studies on early and long-term effects of dioxin exposure: a review. Environ Health Perspect 1998; 106:625-33.
17. Sweeney MH, Hornung RW, Wall DK, et al. Prevalence of diabetes and elevated serum glucose levels in workers exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Organohalogen Compounds 1992; 11:225-26.
18. Calvert GM, Sweeney MH, Deddend J, et al. Evaluation of diabetes mellitus, serum glucose, and thyroid function among United States workers exposed to 2, 4, 7, 8-tetrachlorodibenzo-p-diox-in. Occup Environ Med 1999:270-76.
19. Michalek JE, Akhtar FZ, Kiel JL Serum dioxin, insulin, fasting glucose and sex hormone-binding globulin in veterans of Operation Ranch Hand. J Clin Endocrinol Metab 1999; 56:270-76.
20. Vena J, Boffetta P, Becher H, et al. Exposure to dioxin and nonneoplastic mortality in the expanded IARC International Cohort Study of phenoxy herbicide and chlorophenol production workers and sprayers. Environ Health Perspect 1998; 106(Suppl 2):645-53.
21. Stellman S, Djordjevic MV, Britton JA, et al. Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York. Cancer Epidemiol Biomarkers Prev 2000; 9:1241-49.
22. Helzlsouer KJ, Alberg AJ, Huang HY, et al. Serum concentrations of organochlorine compounds and the subsequent development of breast cancer. Cancer Epidemiol Biomarkers Prev 1999; 8: 525-32.
23. Hunter DJ, Hankinson SE, Laden SM, et al. Plasma organochlorine levels and the risk of breast cancer. N Engl J Med 1997; 337: 1253-58.
24. Sohnlein P, Muller M, Syren K, et al. Epitope spreading and a varying but not disease-specific GAD65 antibody response in type I diabetes. Diabetologia 2000; 43:210-17.
25. Falorni A, Gambelunghe G, Forini F, et al. Autoantibody recognition of COOH-terminal epitopes of GAD65 marks the risk for insulin requirement in adult-onset diabetes mellitus. J Clin Endocrinol Metab 2000; 85:309-16.