Modulation of noradrenergic and serotonergic transmission by noxious stimuli and intrathecal morphine differs in the dorsal raphe nucleus of anesthetized rat: In vivo voltammetric studies

Neuroscience Research

Volumn 44, Issue 1, 2002, Pages 37-44

  Chuma, Toichiro ^a,b   Taguchi, Kyoji ^a   Kato, Masatoshi ^a   Abe, Kenji ^a   Utsunomiya, Iku ^a   Miyamoto, Ken Ichi ^b   Miyatake, Tadashi ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

5 Hydroxyindole signal; Catechol signal; Dorsal raphe nucleus; Morphine; Noxious stimulation

Indexed keywords

5 HYDROXYINDOLE; CARBON FIBER; CATECHOL; MORPHINE; NALOXONE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; CONTROLLED STUDY; DIFFERENTIAL PULSE VOLTAMMETRY; DORSAL RAPHE NUCLEUS; ELECTRIC CURRENT; ELECTRODE; HEAT; IN VIVO STUDY; MALE; MODULATION; NERVE CONDUCTION; NEUROTRANSMISSION; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; NORADRENERGIC SYSTEM; OXIDATION; POTENTIOMETRY; PRIORITY JOURNAL; RAT; SEROTONINERGIC TRANSMISSION; SIGNAL TRANSDUCTION; SKIN; TEMPERATURE;

ANIMALS; CATECHOLS; ELECTROPHYSIOLOGY; HEAT; HINDLIMB; HYDROXYINDOLEACETIC ACID; INJECTIONS, SPINAL; MALE; MORPHINE; NOREPINEPHRINE; OXIDATION-REDUCTION; PAIN; RAPHE NUCLEI; RATS; RATS, WISTAR; SEROTONIN; SYNAPTIC TRANSMISSION;

EID: 0036768309     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(02)00084-6     Document Type: Article

References (45)

1. Andersen E., Dafny N. Dorsal raphe stimulation reduces responses of parafascicular neurons to noxious stimulation. Pain. 15:1983;323-331.
2. Basbaum A.I., Fields H.L. The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat; further studies on the anatomy of pain modulation. J. Comp. Neurol. 187:1979;513-532.
3. Baraban J.M., Aghajanian G.K. Suppression of firing activity of 5-HT neurons in the dorsal raphe by α-adrenoceptor antagonists. Neuropharmacology. 19:1980;355-363.
4. Baraban J.M., Aghajanian G.K. Noradrenergic innervation of serotonergic neurons in the dorsal raphe, demonstration by electron microscopic autoradiography. Brain Res. 204:1981;1-11.
5. Basbaum A.I., Fields H.L. Endogenous pain control system: brainstem spinal pathways and endorphin circuitry. Annu. Rev. Neurosci. 7:1984;309-338.
6. 1 receptor agonists and p-chloroamphetamine. Synapse. 5:1990;120-133.
7. Clement H.W., Gemsa D., Wesemann W. The effect of adrenergic drugs on serotonin metabolism in the nucleus raphe dorsalis of the rat, studied by in vivo voltammetry. Eur. J. Pharmacol. 217:1992;43-48.
8. Dickenson A.H., Sullivan A.F. Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurons in the rat dorsal horn. Pain. 24:1986;211-222.
9. Dong W.-Q., Qiao J.-T., Skolnick M., Dafny N. Focal dorsal raphe stimulation and pinnal electrical stimulation modulation modulate spontaneous and noxious evoked responses in thalamic neurons. Int. J. Neurosci. 57:1991;123-140.
10. Echizen H., Freed C. In vivo electrochemical detection of extraneuronal 5-hydroxyindole acetic acid and norepinephrine in the dorsal raphe nucleus of urethane-anesthetized rats. Brain Res. 277:1983;55-62.
11. Fields H.L., Basbaum A.J. Brainstem control of spinal pain transmission neurons. Ann. Rev. Phys. 40:1978;217-248.
12. Fields H.L., Heinricher M.M., Mason P. Neurotransmitters in nociceptive modulatory circuits. Annu. Rev. Neurosci. 14:1992;219-245.
13. Fritschy J.M., Grzanna R. Distribution of locus coeruleus axons within the rat brain stem demonstrated by phaseolus vulgaris leucoagglutinin anterograde tracing in combination with dopamine-beta-hydroxylase immunofluorescence. J. Comp. Neurol. 293:1990;616-631.
14. Gozariu M., Bouhassira D., Willer J.-C., LeBars D. Temporal summation and a C-fibre reflex in the rat: effects of morphine on facilitory and inhibitory mechanisms. Eur. J. Pharmacol. 232:2000;207-215.
15. Griffith J.L., Gatipon G.B. A comparative study of selective stimulation of raphe nuclei in the cat in inhibiting dorsal horn neuron responses to noxious stimulation. Brain Res. 229:1981;520-524.
16. Guirimand F., Chauvin M., Willer J.C., Le Bars D. Effects of intravenous morphine and buprenorphine on a C-fiber reflex in the rat. J. Pharmacol. Exp. Ther. 273:1995;539-546.
17. 1 autoreceptor subtypes govern serotonin release in dorsal and median raphe nuclei. Neuropharmacology. 40:2001;508-519.
18. 2A adrenoceptors. Neuropharmacology. 41:2001;433-442.
19. Johnson G.A., Kim E.G., Boukma S.J. 5-Hydroxyindole levels in rat brain after inhibition of dopamine-β-hydroxylase. J. Pharmacol. Exp. Ther. 180:1972;539-546.
20. Johnson S.W., North R.A. Opioids excite dopamine neurons by hyperpolarization of local interneurons. J. Neurosci. 12:1992;483-489.
21. Kaisner S., Abdali S.A. Rate-independent inhibition by norepinephrine of 5-HT release from the somatodendritic region of serotonergic neurons. Brain Res. Bull. 55:2001;761-765.
22. Kakeyama M., Yamanouchi K. Female sexual behaviours in male rats with dorsal raphe nucleus lesions; treatment with p-chlorophenylalamine. Brain Res. Bull. 30:1986;705-709.
23. Mantyh P.W., Peschanski M. Spinal projections from the periaqueductal gray and dorsal raphe in the rat, cat and monkey. Neuroscience. 7:1982;2769-2776.
24. Morilak D.A., Fornal C., Jacobs B.L. Single unit activity of noradrenergic neurons in locus coeruleus and serotonergic neurons in the nucleus raphe dorsalis of freely moving cats in relation to the cardiac cycle. Brain Res. 399:1986;262-270.
25. Paxinos, G., Watson, C., 1982. The rat brain in stereotaxic coordinates. Academic Press, New York (1982).
26. Pazos A., Probst A., Palacios J.M. β-adrenoceptor subtypes in the human brain: autoradiographic localization. Brain Res. 358:1985;324-328.
27. Porro C., Cavazzuti M., Galetti A., Sassatelli L. Functional activity mapping of the rat brainstem during formalin-induced noxious stimulation. Neuroscience. 41:1991;667-680.
28. Prieto-Gomez B., Dafny N., Reyes-Vazquez C. Dorsal raphe stimulation, 5-HT and morphine microiontophoresis effects on noxious and nonnoxious identified neurons in the medial thalamus of the rat. Brain Res. 22:1989;937-943.
29. Rivot J.P., Ory-Lavollee L., Chiang C.Y. Differential pulse voltammetry in the dorsal horn of the spinal cord of the anesthetized rat: are the voltammograms related to 5-HT and/or 5-HIAA? Brain Res. 275:1983;311-319.
30. 1A receptor antagonists in the dorsal raphe pathways, role of somatodendric autoreceptors. J. Neurochem. 68:1997;2593-2603.
31. Sanders K.H., Klein C.E., Mayer T.E., Heym C., Handwerker H.O. Differential effects of noxious and nonnoxious input on neurons according to location in ventral periaqueductal grey or dorsal raphe nucleus. Brain Res. 186:1980;83-97.
32. Saavedra J.M., Grobecker H., Zivin J. Catecholamines in the raphe nuclei in rat. Brain Res. 114:1976;343-351.
33. Shigenaga T., Kato M., Taguchi K. In vivo voltammetric studies of the effects of intrathecal morphine on noxious heat stimuli-induced serotonin release in the nucleus raphe magnus of anesthetized rats. Neurosci. Res. 29:1997;257-262.
34. Shima K., Nakamura H., Yamamoto M., Aya K., Inase M. Firing properties of two types of nucleus raphe dorsalis neurons during the sleep-waking cycle and their responses to sensory stimuli. Brain Res. 399:1986;317-326.
35. 1 receptors associated with dorsal raphe neurons. Dev. Brain Res. 46:1989;173-186.
36. 1B agonists. Synapse. 1:1989;3-9.
37. 1A autoreceptors modulate 5-HT release in the guinea pig dorsal raphe nucleus. Neuropharmacology. 33:1994;393-402.
38. Taguchi K., Suzuki Y. Effects of morphine on the electrochemical signal modified by noxious stimuli in the nucleus raphe magnus of anesthetized rats. Neuropharmacology. 30:1991;1225-1231.
39. Unnerstall J.R., Kopajtic T.A., Kuhar M.J. Distribution of alpha2-agonist binding sites in the rat and human central nervous system, analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents. Brain Res. 319:1984;69-101.
40. Wang Q.P., Nakai Y. The dorsal raphe: an important nucleus in pain modulation. Brain Res. Bull. 34:1994;575-585.
41. Werner J., Bienek A. Loss and restoration of preoptic thermoreactiveness after lesions of the rostral raphe nuclei. Exp. Brain Res. 80:1990;429-435.
42. Wiesenfeld-Hallin Z., Duranti R. Intrathecal cholecystokinin interacts with morphine but not substance P modulating the nociceptive flexion reflex in the rat. Peptides. 8:1987;153-158.
43. Wiesenfeld-Hallin Z., Xu X.J., Hakanson R., Feng D.M., Folkers K. Low-dose intrathecal morphine facilitates the spinal flexor reflex by releasing different neuropeptides in rats with intact and sectioned peripheral nerves. Brain Res. 551:1991;157-162.
44. Xu X.J., Wiesenfeld-Hallin Z. The threshold for the depressive effect of intrathecal morphine on the spinal nociceptive flexor reflex is increased during autonomy after sciatic nerve section in rats. Pain. 46:1991;223-229.
45. Yaksh T.L., Rudy T.A. Chronic catheterization of the spinal subarachnoid space. Physiol. Behav. 17:1976;1032-1036.