Gemcitabine plus cisplatin in the treatment of patients with advanced non-small cell lung cancer: A phase II study

Anticancer Research

Volumn 22, Issue 5, 2002, Pages 3039-3043

  Bretti, S ^a   Manzin, E ^a   Loddo, C ^a   Berruti, A ^b   Bombaci, S ^a   Vellani, G ^a   Celano, A ^c  

^a Ospedale di Ivrea   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c MOLINETTE HOSPITAL   (Italy)

Author keywords

Cisplatin; Gemcitabine; Non small cell lung cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; GEMCITABINE;

ADULT; AGED; ALOPECIA; ARTICLE; ASTHENIA; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CHEMOTHERAPY INDUCED EMESIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONSTIPATION; DIARRHEA; DISEASE COURSE; DRUG EFFICACY; DRUG POTENTIATION; DRUG SAFETY; FEMALE; HUMAN; LEUKOPENIA; LUNG CANCER; LUNG NON SMALL CELL CANCER; MALE; MUCOSA INFLAMMATION; NAUSEA; NEPHROTOXICITY; NEUROTOXICITY; PATIENT MONITORING; PERIPHERAL NEUROPATHY; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; STOMATITIS; THROMBOCYTOPENIA; TREATMENT OUTCOME; VOMITING;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; CISPLATIN; DEOXYCYTIDINE; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING;

EID: 0036765964     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Esteve J, Kricker A and Ferlay J et al: Facts and Figures of Cancer in the European Community. Lyon, France. International Agency for Research on Cancer, 1993.
2. Non-Small Cell Lung Cancer Collaborative Group: Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 311: 899-909, 1995.
3. Cullen MH: The MIC regimen in non-small cell lung cancer. Lung Cancer 9: 81-89, 1993 (suppl 2).
4. Fernandez C, Rosell R and Abad-Esteve A et al.: quality of life during chemotherapy in non-small cell lung cancer patients. Acta Oncol 28: 29-33, 1989.
5. Rapp E, Pater JL and Willian A et al: Chemotherapy can prolong survival in patients with advanced non-small cell lung cancer: Reporting of Canadian Multicenter Randomised Trial. J Clin Oncol 6: 633-641, 1988.
6. Font A, Moyano A and Blanco E et al: Cisplatin plus etoposide at maximum tolerated dose with or without recombinant human granulocyte-macrophage colony-stimulating factor in advanced non-small cell lung cancer. A phase III randomised trial. Proc Am Soc Clin Oncol 15: 381, 1996.
7. Hertel LW, Boder GB and Kroin JS et al: Evaluation of the antitumor activity of gemcitabine (2′, 2′ difluorodeoxycytidine). Cancer Res 50: 4417-22, 1990.
8. Abratt RP, Bezwoda WR and Falkson G et al: Efficacy and safety profile of gemcitabine in non-small cell lung cancer: A phase II study. J Clin Oncol 12: 1821-1826, 1994.
9. Gatzemeier U, Shepherd FA and Le Chevalier T et al: Activity of gemcitabine in patients with non-small cell lung cancer: A multicentre extended phase II study. Eur J Cancer 32A: 243-248, 1996.
10. 185neu 1. Cancer Res 56: 794-801, 1996.
11. Peters GJ, Bergman AM and Ruiz van Haperen VWT et al: Interaction between cisplatin and gemcitabine in vitro and in vivo. Semin Oncol 22: 72-79, 1995 (suppl 11).
12. Bergman AM, Ruiz van Haperen VWT and Veerman G et al: Synergistic interaction between cisplatin and gemcitabine in vitro. Clin Cancer Res 2: 521-30, 1996.
13. Peters GJ, Ruiz van Haperen VWT and Bergman AM et al: Preclinical combination therapy with gemcitabine and mechanism of resistance. Semin Oncol 23: 16-24, 1996 (suppl 10).
14. Braakhuis BJM, Ruiz van Haperen VWT and Boven E et al: Schedule dependent antitumor effect of gemcitabine in vivo model system. Semin Oncol 22: 42-46, 1995 (suppl 11).
15. Van Moorsel CJA, Peters G and Pinedo HM et al: Gemcitabine: Future prospects of single-agent and combination studies. Oncologist 2: 127-134, 1997.
16. WHO/UICC Handbook for Reporting Results of Cancer Treatment. WHO offset publication N° 48, Geneve, 1979.
17. Kaplan EL and Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53: 457-81, 1958
18. Valeriote FA and Edelstein MB: The role of cell kinetics in cancer chemotherapy. Semin Oncol 4: 217-226, 1977
19. Crino L, Scagliotti G and Marangolo M et al: Cisplatin-gemcitabine combination in advanced non-small cell lung cancer: A phase II study. J Clin Oncol 15: 297-303, 1997.