Short-term effects of TNP-470 in combination with cisplatin in the rat model of bladder cancer

In Vivo

Volumn 16, Issue 5, 2002, Pages 293-297

  Zhang, Xianghua ^a   Yamashita, Motoki ^a   Uetsuki, Hirotsugu ^a   Kakeh, Yoshiyuki ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

Angiogenesis; Apoptosis; Cell proliferation; Cisplatin; Rat bladder cancer; TNP 470

Indexed keywords

CISPLATIN; FUMAGILLOL CHLOROACETYLCARBAMATE; N BUTYL N (4 HYDROXYBUTYL)NITROSAMINE; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC ANTIBIOTIC; CD31 ANTIGEN; CYCLOHEXANE DERIVATIVE; DNA; KI 67 ANTIGEN; O-(CHLOROACETYLCARBAMOYL)FUMAGILLOL; SESQUITERPENE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER INVASION; CELL DENSITY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG SENSITIVITY; HISTOPATHOLOGY; MALE; MICROVASCULATURE; NONHUMAN; RAT; SHORT COURSE THERAPY; STATISTICAL SIGNIFICANCE; TRANSITIONAL CELL CARCINOMA; ANIMAL; BLADDER TUMOR; CELL DIVISION; DISEASE MODEL; DRUG COMBINATION; ENZYME IMMUNOASSAY; MICROCIRCULATION; NICK END LABELING; PATHOLOGY; VASCULARIZATION; WISTAR RAT;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIGENS, CD31; APOPTOSIS; CARCINOMA, TRANSITIONAL CELL; CELL DIVISION; CISPLATIN; CYCLOHEXANES; DISEASE MODELS, ANIMAL; DNA, NEOPLASM; DRUG THERAPY, COMBINATION; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MICROCIRCULATION; NEOPLASM INVASIVENESS; RATS; RATS, WISTAR; SESQUITERPENES; URINARY BLADDER NEOPLASMS;

EID: 0036761795     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6, 1990.
2. Folkman J and Shing Y: Angiogenesis. J Biol Chem 267: 10931-10934, 1992.
3. Folkman J: Tumor angiogensis: Therapeutic implications. N Engl J Med 285: 1182-1186, 1971.
4. Ingber D, Fujita T, Kishimoto S et al: Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 348: 555-557, 1990.
5. Fujioka T, Hasegawa M, Ogiu K et al: Antitumor effects of angiogenesis inhibitor O-(chloroacetyl-carbomoyl) fumagillol (TNP-470) against murine renal cell carcinoma. J Urol 155: 1775-1778, 1996.
6. Folkman J: Tumor angiogenesis. In: Wells SA Jr, and Sharp PA (Eds): Accomplishments in Cancer Research 1997. Philadelphia, Lippincott, Williams & Wilkins, pp 32-44, 1998.
7. Koivisto P, Visakorpi T, Rantala I et al: Increased cell proliferation activity and decreased cell death are associated with the emergence of hormone-refractory recurrent prostate cancer. J Pathol 183; 51-56, 1997.
8. Ito Y, Matsuura N, Sakon M et al: Both cell proliferation and apoptosis significantly predict shortened disease-free survival in hepatocellular carcinoma. Br J Cancer 81: 747-751, 1999.
9. Bochner BH, Cote RJ, Weidner N et al: Angiogenesis in bladder cancer: Relationship between microvessel density and tumor prognosis. J Natl Cancer Inst 87: 1603-1612, 1995.
10. Zhang X, Kong C and Takenaka I: Evaluation of cell proliferation, apoptosis, and angiogenesis in transitional cell carcinoma of the renal pelvis and ureter. Urology 57: 981-985, 2001.
11. Sobin LH and Wittekind C: TNM Classification of Malignant Tumors. 5th Edition. John Wiley & Sons, Inc., New-York, 1997.
12. Zhang X, Jin L and Takenaka I: MVAC chemotherapy-induced apoptosis and p53 alterations in the rat model of bladder cancer. Urology 52: 925-931, 1998.
13. Zhand X and Takenaka I: Morphological changes in the basement membrane during progression from non-invasive to invasive rat bladder cancer induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Br J Urol 79: 378-382, 1997.
14. Sin N, Meng L, Wang MQW et al: The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc Natl Acad Sci USA 94: 6099-6103, 1997.
15. Tanaka Y, Kawamata H, Fujimoto K et al: Angiogenesis inhibitor TNP-470 suppresses tumorigenesis in rat urinary bladder. J Urol 157: 683-688, 1997.
16. Osawa S, Terashima Y, Kimura G et al: Antitumor effects of the angiogenesis inhibitor AGM-1470 on rat urinary bladder tumours induced by N-butyl-N(4-hydroxybutyl)nitrosamine. Br J Urol 83: 123-128, 1999.
17. Hickman JA: Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11: 121-139, 1992.
18. Shishido T, Yasoshima T, Denno R et al: Inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP-470 in combination with cisplatin. Jpn J Cancer Res 89: 963-969, 1998.
19. Kato T, Sato K, Kakinuma H et al: Enhanced suppression of tumor growth by combination of angiogenesis inhibitor O-(chloroacetyl-carbomoyl)fumagillol (TNP-470) and cytotoxic agents in mice. Cancer Res 54: 5143-5147, 1994.
20. Yamaoka M, Yamamoto T, Ikeyama S et al: Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cells lines. Cancer Res 53: 5233-5236, 1993.