The efficacy of orgotein in the treatment of acute toxicity due to radiotherapy on head and neck tumors

Tumori

Volumn 88, Issue 5, 2002, Pages 385-389

  Valencia, Javier ^a   Velilla, Carmen ^a   Urpegui, Angel ^a   Alvarez, Ignacio ^a   Llorens, M Angeles ^a   Coronel, Pilar ^a   Polo, Sonia ^a   Bascón, Natividad ^a   Escó, Ricardo ^a  

^a HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

Author keywords

Acute toxicity; Head and neck cancer; Orgotein; Radiotherapy; Superoxide dismutase

Indexed keywords

SUPEROXIDE DISMUTASE;

ACUTE TOXICITY; ADULT; ARTICLE; CANCER RADIOTHERAPY; CLINICAL ARTICLE; DRUG EFFICACY; DYSPHAGIA; FEMALE; HEAD AND NECK TUMOR; HUMAN; LOGISTIC REGRESSION ANALYSIS; MALE; MUCOSA INFLAMMATION; RADIATION INJURY; RATING SCALE; TREATMENT OUTCOME;

EID: 0036757924     PISSN: 03008916     EISSN: None     Source Type: Journal    
DOI: 10.1177/030089160208800507     Document Type: Article

References (33)

1. Naya MJ, Pereboom D, Ortego J, Alda JO, Lanas A: Super-oxide anions produced by inflammatory cells play an important part in the pathogenesis of acid and pepsin induced oesophagitis in rabbits. Gut, 40: 175-181, 1997.
2. Leborgne J, Leborgne F, Zubizarreta E, Ortega B, Mezzera J: Corticosteroids and radiation mucositis in head and neck cancer. A double-blind placebo controlled randomized trial. Radiother Oncol, 47: 145-148, 1998.
3. Kannan V, Bapsy PP, Anantha N, Doval DC, Vaithianathan H, Banumathy G, Reddy KB, Kumaraswamy SV, Shenoy AM: Efficacy and safety of granulocyte macrophage-colony stimulating factor (GM-CSF) on the frequency and severity of radiation mucositis in patients with head and neck carcinoma. Int J Radiat Oncol Biol Phys, 37: 1005-1010, 1997.
4. Rovirosa A, Ferré J, Biete A: Granulocyte macrophage-colony-stimulating factor mouthwashes heal oral ulcers during head and neck radiotherapy. Int J Radiat Oncol Biol Phys, 41: 747-754, 1998.
5. Ferrer C, Dualde D, Ferrer E, Rodríguez M, Pinazo J, Sancho R: Effect of GM-CSF in radiation induced mucositis. In: First World Congress on Head and Neck Oncology, JJ Alvarez Vicent (Ed), pp 885-888, Monduzzi, Bologna, 1998.
6. Lievens Y, Haustermans K, Van der Weyngaert D, Van der Bogaert W, Scalliet P, Hutsebaut L, Fowler J, Lambin P: Does sucralfate reduce the acute side-effects in head and neck cancer treated with radiotherapy? A double-blind randomized trial. Radiother Oncol, 47: 149-153, 1998.
7. Makkonen TA, Bostrom P, Vilja P, Joensuu H: Sucralfate mouth washing in the prevention of radiation-induced mucositis: A placebo-controlled double-blind randomized study. Int J Radiat Oncol Biol Phys, 30: 177-182, 1994.
8. Sur RK, Kochhar R, Singh DP: Oral sucralfate in acute radiation oesophagitis. Acta Oncol, 33: 61-63, 1994.
9. Valls A, Algara M, Domenech M, Llado A, Ferrer E, Marin S: Efficacy of sucralfate in the prophylaxis of diarrhea secondary to acute radiation-induced enteritis. Preliminary results of a double-blind randomized trial. Med Clin, 96: 449-452, 1991.
10. Henriksson R, Franzen L, Littbrand B: Prevention and therapy of radiation-induced bowel discomfort. Scand J Gastroenterol, 27 (Suppl 191): 7-11, 1992.
11. Baughan CA, Canney PA, Buchanan RB, Pickering RM: A randomized trial to assess the efficacy of 5-aminosalicylic acid for the prevention of radiation enteritis. Clin Oncol, 5: 19-24, 1993.
12. Resbeut M, Marteau P, Cowen D, Richaud P, Bourdin S, Dubois JB, Mere P, N'Guyen TD: A randomized double blind placebo controlled multicenter study of mesalazine for the prevention of acute radiation enteritis. Radiother Oncol, 44: 59-63, 1997.
13. Rubin P: Special issue: Late effects of normal tissues consensus conference, including RTOG/EORTC SOMA scales. Int J Radiat Oncol Biol Phys, 31: 1035-1360, 1995.
14. McCord JM, Fridovich I: The biology and pathology of oxygen radicals. Ann Intern Med, 89: 122, 1978.
15. Edsmyr F, Huber W, Menander K: Orgotein efficacy in ameliorating side effects due to radiation therapy. I. Doubleblind, placebo-controlled trial in patients with bladder tumors. Curr Therap Res, 19: 198-211, 1976.
16. Sanchiz F, Milla A, Artola N, Julia JC, Moya LM, Pedro A, Vila A: Prevention of radioinduced cystitis by orgotein: A randomized study. Anticancer Res, 16: 2025-2028, 1996.
17. Steel G: Introduction: The significance of radiobiology for radiotherapy. In: Basic Clinical Radiobiology, Steel G, Arnold E (Eds), pp 1-7, Edward Arnold Publishers, Boston, 1993.
18. Valencia J, Velilla MC, Lainez C, López P, Bascón N, Martí JL, Escó R: Influye el uso de Orgoteína en el control tumoral? Rev Oncol, 1(S3): 59, 1999.
19. Nakano T, Oka K, Taniguchi N: Manganese superoxide dismutase expression correlates with p53 status and local recurrence of cervical carcinoma treated with radiation therapy. Cancer Res, 56: 2771-2775, 1996.
20. Urano M, Kuroda M, Reynolds R, Oberley TD, Clair DK: Expression of manganese superoxide dismutase reduces tumor control radiation dose: Gene-radiotherapy. Cancer Res, 55: 2490-2493, 1995.
21. Edeas M, Peltier E, Claise C, Khalfoun Y, Lindenbaum A: Immunocytochemical study of uptake of exogenous carrier-free copper-zinc superoxide dismutase by peripheral blood lymphocytes. Cell Mol Biol, 42: 1137-1143, 1996.
22. Edeas M, Peltier E, Claise C, Khalfoun Y, Capron F, Lindenbaum A: Protective effects of exogenous copper-zinc super-oxide dismutase on the TNFa-induced oxidative stress and HIV replication. Cell Pharmacol AIDS Sci, 3: 295-305, 1996.
23. Talke M: Comparision of intra-articular use of super-oxide dismutase with a corticoid in the treatment of degenerative and inflammatory alterations of the finger joints. In: Super-Oxide Dismutase, Biochimie und Therapeutischer Einsatz, Puhl W, Sies H (Eds), pp 99-111, Perimed Fachbuch Verlag, 1982.
24. Niwa Y, Somiya K, Michelson AM, Puget K: Effect of liposomal encapsulated superoxide dismutase on active-oxygen-related human disorders. A preliminary study. Free Radical Res Commun, 6: 137-153, 1986.
25. Weening RS, Wevwr R, Roos D: Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocyte. J Lab Clin Med, 85: 245, 1975.
26. Babior BM, Curnutte JT, Kipnes RS: Evidence for the participation of superoxide in bacterial killing by xanthine oxidase. J Lab Clin Med, 85: 235, 1975.
27. Kehler JP: Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol, 23: 21-48, 1993.
28. McCord JM: Human disease, free radicals and the oxidant/antioxidant balance. Clin Biochem, 26: 351-357, 1993.
29. McCord JM, Wong K, Stokes SH, Petrone WF, English D: Superoxide and inflammation: A mechanism for the anti-inflamatory activity of super-oxide dismutase. Acta Physol Scand, 492: 25-30, 1980.
30. Marberger H, Huber W, Menander-Huber K, Bartsch G: Orgotein: A new drug for the treatment of radiation cystitis. Eur J Rheum, 4: 244-249, 1981.
31. Valencia J, Escó R, Bascón N, Lainez C, Bellosta R, López P, Fuertes F: Analysis of results of the treatment with orgotein associated to radiotherapy. Rev Oncol, 1: 307-312, 1999.
32. Menander-Huber K, Edsmyr F, Huber W: Orgotein (superoxide dismutase): A drug for the amelioration of radiation-induced side effects. A double-blind placebo-controlled study in patients with bladder tumours. Urol Res, 6: 121-123, 1978.
33. Ruiz V, Algara M, Foro P, Reig A, Valls A: Eficacia de la orgoteina en el tratamiento de la fibrosis y xerostomia radioinducidas. Oncologfa, 18: 60-64, 1995.