Superoxide anions produced by inflammatory cells play an important part in the pathogenesis of acid and pepsin induced oesophagitis in rabbits

Gut

Volumn 40, Issue 2, 1997, Pages 175-181

  Naya, M J ^a,c   Pereboom, D ^c   Ortego, J ^b   Aida, J O ^c   Lanas, A ^a  

^a Gastroenterology Services Mendaro   (Spain)

^b Pathology Services

^c HOSPITAL CLÍNICO UNIVERSITARIO LOZANO BLESA   (Spain)

Author keywords

Acid; Free radical; Inflammation; Oesophagitis; Pepsin; Superoxide anion

Indexed keywords

ACID; CATALASE; DIMETHYL SULFOXIDE; KETOTIFEN; KETOTIFEN FUMARATE; PEPSIN A; SCAVENGER; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ESOPHAGITIS; INFLAMMATORY CELL; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0031049382     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.40.2.175     Document Type: Article

References (38)

1. Kahrilas PJ, Hogan WJ. Gastroesophageal reflux diseases. In: Sleisenger MH, Fordtran JS, eds. Gastrointestinal diseases. London: WB Saunders, 1993: 378-401.
2. Orlando RC. Esophageal epithelial defences against acid injury. Am J Gastroenterol 1994; 89: 48-52.
3. Khalbuss WE, Marousis CG, Subramanyam M, Orlando RC. Effect of HCl on transmembrane potentials and intracellular pH in rabbit esophageal epithelium. Gastroenterology 1995; 108: 662-72.
4. Grisham MB, Hernández LA, Granger DN. Xanthine oxidase and neutrophil in nitration in intestinal ischemia. Am J Physiol 1986; 251: G567-74.
5. Tarnasky PR, Livingston EH, Jacobs KM, Zimmerman BJ, Guth PH, Garrick TR. Role of oxyradicals in cold water immersion restraint-induced gastric mucosal injury in the rat. Dig Dis Sci 1990; 35: 173-7.
6. Wallace JL, Arfors KE, Mcknight GW. A monoclonal antibody against the CD18 leukocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit. Gastroenterology 1991; 100: 878-83.
7. Terano A, Hiraishi H, Ota S, Shiga J, Sugimoto T. Role of Superoxide and hydroxyl radicals in rat gastric mucosal injury induced by ethanol. Gastroenterol Jpn 1989; 24: 488-93.
8. Yasue N, Guth PH. Role of exogenous acid and retransfusion in hemorrhagic shock induced gastric lesions in the rat. Gastroenterology 1988; 94: 1135-43.
9. Nakamura K, Aoike A, Rokutan K, Hosokawa T, Koyama K, Kawai K. The role of oxygen radicals in the pathogenesis of gastric mucosal lesions induced in mice by feeding-restriction stress. Scand J Gastroenterol 1989; 24 (suppl 162): 47-50.
10. Binnaka T, Yamaguchi T, Hirohara J, Hiramatsu A, Mizuno T, Sameshima Y. Gastric mucosal damage induced in rats by intravenous administration of platelet-activating factor. Scand J Gastroenterol 1989; 24 (suppl 162): 67-70.
11. Perminder SP, Colin JG, Meron RJ. A radical view of the stomach: the role of oxygen-derived free radicals and anti-oxidants in gastroduodenal disease. Eur J Gastroenterol Hepatol 1995; 7: 265-71.
12. Stein HJ, Espluges J, Whittle BJ, Bauerfeind P, Hinder RA, Blum AL. Direct cytotoxic effect of oxygen radicals on the gastric mucosa. Surgery 1989; 106: 318-24.
13. Matsumoto T, Moriguchi R, Yamada H. Role of polymorphonuclear leucocytes and oxygen-derived free radicals in the formation of gastric lesions induced by HCl/ethanol, and a possible mechanism of protection by anti-ulcer polysaccharide. J Pharm Pharmacol 1993; 45: 535-9.
14. Stein BE, Schwartzman ML, Carroll MA, Stahl RE, Rosenthal WS. Role of arachidonic acid metabolites in acid-pepsin injury to rabbit esophagus. Gastroenterology 1989; 97: 278-83.
15. Jiménez P, Esteva F, Piazuelo E, Garcia MA, Lanas A. Prostaglandins and arachidonic acid metabolites produced by esophageal mucosal cells: implications for mucosal defense. Eur Surg Res 1994; 26: 35-6.
16. Lillemoe KD, Johnson LF, Harmon JW. Alkaline esophagitis: a comparison of the ability of components of gastroduodenal contents to injure the rabbit esophagus. Gastroenterology 1983; 85: 621-8.
17. Lanas A, Sousa FL, Ortego J, Soria J, Esteva F, Blas JM, et al. Aspirin renders the esophageal mucosa more permeable to acid and pepsin in rabbits by different mechanisms. Eur J Gastroenterol Hepatol 1995; 7: 1065-72.
18. Wetscher GJ, Hunder PR, Bagchi D, Perdikis G, Redmond EJ, Glaser K, et al. Free radical scavengers prevent reflux esophagitis in rats. Dig Dis Sci 1995; 40: 1292-6.
19. Schweitzer EJ, Bass BJ, Johnson LF, Harmon JW. Sucralfate prevents experimental peptic esophagitis in rabbits. Gastroenterology 1985; 88: 611-9.
20. Tay HP, Chaparala RC, Harmon JW, Huesken J, Saini N, Hakki FZ, et al. Bismuth subsalicylate reduces peptic injury of the oesophagus in rabbits. Gut 1990; 31: 11-6.
21. Trevethick MA, Clayton NM, Strong P, Harman IW. Do infiltrating neutrophils contribute to the pathogenesis of indomethacin induced ulceration of the rat gastric antrum? Gut 1993; 34: 156-60.
22. + antiport. Gastroenterology 1990; 99: 909-17.
23. Lanas A, Nerin J, Esteva F, Sáinz R. Nonsteroidal anti-inflammatory drugs and prostaglandin effects on pepsinogen secretion by dispersed human peptic cells. Gut 1995; 36: 657-63.
24. Rothe G, Valet G. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2',7' dichlorofluorescein. J Leukoc Biol 1990; 47: 440-8.
25. Rothe G, Oser A, Valet G. Didydrorhodamine 123: a new flow cytometric indicator for respiratory burst activity in neutrophil granulocytes. Naturwissenchaften 1988; 75: 354-5.
26. Halliwell B. Reactive oxygen species in living systems: source, biochemistry and role in human disease. Am J Med 1991; 91: 14-22.
27. Mutoh H, Ota S, Hiraishi H, Ivey KJ, Terano A, Sugimoto T. Reduced glutathione protects cultured gastric mucosal cells from suckling rats against acid. Am J Physiol 1991; 261: 65-70.
28. Olayaee M, Sontag S, Salman W, Schnell T, Mobarhan S, Eiznhamer D, et al. Mucosal reactive oxygen species production in oesophagitis and Barrett's oesophagus. Gut 1995; 37: 168-73.
29. Pathoulakis C, Karmeli F, Kelly CP, Eliakim R, Joshi MA, O'Keane CJ, et al. Ketotifen inhibits Clostridium difficile toxin A induced enteritis in rat ileum. Gastroenterology 1993; 105: 701-7.
30. Shiratori Y, Takada H, Hai K, Kiriyama H, Mawet E, Komatsu Y, et al. Effect of antiallergic agents on chemotaxis of neutrophils by stimulation of chemotactic factor released from hepatocytes exposed to ethanol. Dig Dis Sci 1994; 39: 1569-75.
31. Hossain M, Okubo Y, Sekiguchi M. Effects of various drugs (staurosporine, herbimycin A, Ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability. Arerugi 1994; 43: 711-7.
32. Hojo M, Hamasaki Y, Fujita I, Koga H, Matsumoto S, Miyazaki S. Effects of antiallergy drugs on fMet-Leu-Phe-stimulated superoxide generation in human neutrophils. Ann Allergy 1994; 73: 21-6.
33. Eliakim R, Karmeli F, Okon E, Rachmilewitz D. Ketotifen effectively prevents mucosal damage in experimental colitis. Gut 1992; 33: 1498-503.
34. Eliakim R, Karmeli F, Chorev M, Okon E, Rachmilewitz D. Effect of drugs on colonic eicosanoid accumulation in active ulcerative colitis. Scan J Gastroenterol 1992; 27: 968-72.
35. Eliakim R, Karmeli F, Rachmilewitz D. Ketotifen old drug, new indication: reduction of gastric mucosal injury. Scand J Gastroenterol 1993; 28: 202-4.
36. Kubes P, Kanwar S, Niu XF, Gaboury JP. Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells. FASEB J 1993; 7: 1293-9.
37. Barclay RL, Dinda PK, Morris GP, Paterson WG. Morphological evidence of mast cell degranulation in an animal model of acid-induced esophageal mucosal injury. Dig Dis Sci 1995; 40: 1651-8.
38. Norris HT, Zamcheck N, Gottlieb LS. The presence and distribution of mast cells in the human gastrointestinal tract at autopsy. Gastroenterology 1963; 44: 448-55.