New 3-benzisothiazolyl and 3-benzisoxazolylpiperazine derivatives with atypical antipsychotic binding profile

European Journal of Medicinal Chemistry

Volumn 37, Issue 9, 2002, Pages 721-730

  Orjales, Aurelio ^a   Mosquera, R ^a   Toledo, Antonio ^a   Pumar, Carmen ^a   Labeaga, Luis ^a   Innerárity, Ana ^a  

^a FAES FARMA SA   (Spain)

Author keywords

5 HT receptors; Antipsychotic; D2 receptor; Dopamine; Serotonin

Indexed keywords

1 [2 [4 (1,2 BENZISOTHIAZOL 3 YL) 1 PIPERAZINYL]ETHYL] 3,4 DIHYDRO 3 METHYL 2(1H) QUINAZOLINONE; 2 [2 [4 (1,2 BENZISOTHIAZOL 3 YL) 1 PIPERAZINYL]ETHYL] 1(2H) ISOQUINOLINONE; 2 [2 [4 (1,2 BENZISOTHIAZOL 3 YL) 1 PIPERAZINYL]ETHYL] 1,4 DIHYDRO 4,4 DIMETHYL 3(2H) ISOQUINOLINONE; 2 [2 [4 (1,2 BENZISOTHIAZOL 3 YL) 1 PIPERAZINYL]ETHYL] 3,4 DIHYDRO 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; 2 [2 [4 (1,2 BENZISOXAZOL 3 YL) 1 PIPERAZINYL]ETHYL] 3,4 DIHYDRO 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; 3 [2 [4 (1,2 BENZISOTHIAZOL 3 YL) 1 PIPERAZINYL]ETHYL] 3,4 DIHYDRO 1 METHYL 2(1H) QUINAZOLINONE; ATYPICAL ANTIPSYCHOTIC AGENT; CLOZAPINE; DOPAMINE; DOPAMINE 2 RECEPTOR; RISPERIDONE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG; ZIPRASIDONE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EVALUATION; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ALKYLATION; ANIMALS; ANTIPSYCHOTIC AGENTS; BINDING, COMPETITIVE; CEREBRAL CORTEX; DOPAMINE ANTAGONISTS; INDICATORS AND REAGENTS; KINETICS; MALE; NEOSTRIATUM; PIPERAZINES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RISPERIDONE; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036755092     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(02)01391-0     Document Type: Article

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