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Volumn 25, Issue 9, 2002, Pages 466-474

Short-term immunotherapy with tree pollen allergoids and the adjuvant monophosphoryl lipid-A - Results from a multicentre, placebo-controlled, randomised, double-blind study;Kurzzeit-immuntherapie mit baumpollen-allergoiden und dem adjuvans monophosphoryl lipid-A: Ergebnisse einer randomisierten, doppelblinden, plazebokontrollierten multicenterstudie

Author keywords

Adjuvant; Allergoids; Asthma; Conjunctivitis; Monophosphory lipid A; MPL; Rhinitis; Short term immunotherapy; Tree pollen

Indexed keywords

IMMUNOGLOBULIN E ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; PHOSPHORYL LIPID A; PLACEBO; POLLEN ANTIGEN; TYROSINE;

EID: 0036750172     PISSN: 03445062     EISSN: None     Source Type: Journal    
DOI: 10.5414/alp25466     Document Type: Article
Times cited : (27)

References (31)
  • 1
    • 0031817107 scopus 로고    scopus 로고
    • Allergen immunotherapy: Therapeutic vaccines for allergic diseases. WHO position paper
    • Bousquet J., R.F. Lockey, H.-J. Malling: Allergen immunotherapy: therapeutic vaccines for allergic diseases. WHO position paper. Allergy 53 (Suppl.), 1-42 (1998).
    • (1998) Allergy , vol.53 , Issue.SUPPL. , pp. 1-42
    • Bousquet, J.1    Lockey, R.F.2    Malling, H.-J.3
  • 2
    • 0034110867 scopus 로고    scopus 로고
    • Mechanisms of specific immunotherapy
    • Akdis C.A., K. Blaser: Mechanisms of specific immunotherapy. Allergy 55, 522-530 (2000).
    • (2000) Allergy , vol.55 , pp. 522-530
    • Akdis, C.A.1    Blaser, K.2
  • 3
    • 0034012994 scopus 로고    scopus 로고
    • Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration
    • Baldridge J.R., Y. Yorgensen, J.R. Ward, J.T. Ulrich: Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration. Vaccine 18, 2416-2425 (2000).
    • (2000) Vaccine , vol.18 , pp. 2416-2425
    • Baldridge, J.R.1    Yorgensen, Y.2    Ward, J.R.3    Ulrich, J.T.4
  • 4
    • 0030903223 scopus 로고    scopus 로고
    • Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitisations in children
    • Des Roches A., L. Paradis, J.-L. Ménardo, S. Bouges, J.-P. Daurés, J. Bousquet: Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitisations in children. J. Allergy Clin. Immunol. 99, 450-453 (1997).
    • (1997) J. Allergy Clin. Immunol. , vol.99 , pp. 450-453
    • Des Roches, A.1    Paradis, L.2    Ménardo, J.-L.3    Bouges, S.4    Daurés, J.-P.5    Bousquet, J.6
  • 5
    • 0034995781 scopus 로고    scopus 로고
    • A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A reduces allergic symptoms after only four preseasonal injections
    • Drachenberg K.J., A.W. Wheeler, P. Stuebner, F. Horak: A well-tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A reduces allergic symptoms after only four preseasonal injections. Allergy 56, 498-505 (2001).
    • (2001) Allergy , vol.56 , pp. 498-505
    • Drachenberg, K.J.1    Wheeler, A.W.2    Stuebner, P.3    Horak, F.4
  • 6
    • 0031784380 scopus 로고    scopus 로고
    • Immunologic changes associated with allergen immunotherapy
    • Durham S.R., S.J. Till: Immunologic changes associated with allergen immunotherapy. J. Allergy Clin. Immunol. 102, 157-164 (1998).
    • (1998) J. Allergy Clin. Immunol. , vol.102 , pp. 157-164
    • Durham, S.R.1    Till, S.J.2
  • 8
    • 0035686496 scopus 로고    scopus 로고
    • Do early childhood immunizations influence the development of atopy and do they cause allergic reactions?
    • Grüber C., L. Nilsson, B. Björksten: Do early childhood immunizations influence the development of atopy and do they cause allergic reactions? Pediatr. Allergy Immunol. 12, 296-311 (2002).
    • (2002) Pediatr. Allergy Immunol. , vol.12 , pp. 296-311
    • Grüber, C.1    Nilsson, L.2    Björksten, B.3
  • 9
    • 0026703432 scopus 로고
    • Early interferon-γ as a marker for adjuvants that enhance protective immunity
    • Gustafson G.L., M.J. Rhodes: Early interferon-γ as a marker for adjuvants that enhance protective immunity. Res. Immunol. 143, 483-488 (1990).
    • (1990) Res. Immunol. , vol.143 , pp. 483-488
    • Gustafson, G.L.1    Rhodes, M.J.2
  • 10
    • 19144370919 scopus 로고    scopus 로고
    • Safety, immunogenicity and efficacy of Plasmodium falciparum repeatless circumsporozoite protein vaccine encapsulated in liposomes
    • Heppner D.G., G.M. Gordon, M. Gross: Safety, immunogenicity and efficacy of Plasmodium falciparum repeatless circumsporozoite protein vaccine encapsulated in liposomes. J. Infect. Dis. 174, 361-366 (1996).
    • (1996) J. Infect. Dis. , vol.174 , pp. 361-366
    • Heppner, D.G.1    Gordon, G.M.2    Gross, M.3
  • 12
    • 0033820839 scopus 로고    scopus 로고
    • Die spezifische Immuntherapie (Hyposensibilisierung) mit Allergenen. Positionspapier der Deutschen Gesellschaft für Allergologie und klinische Immunologie
    • Kleine-Tebbe J., T. Fuchs, L. Klimek, J. Kühr, U. Lepp, B. Niggemann, J. Rakoski, H. Renz, J. Saloga, J. Simon: Die spezifische Immuntherapie (Hyposensibilisierung) mit Allergenen. Positionspapier der Deutschen Gesellschaft für Allergologie und klinische Immunologie. Allergo J. 9, 317-324 (2000).
    • (2000) Allergo J. , vol.9 , pp. 317-324
    • Kleine-Tebbe, J.1    Fuchs, T.2    Klimek, L.3    Kühr, J.4    Lepp, U.5    Niggemann, B.6    Rakoski, J.7    Renz, H.8    Saloga, J.9    Simon, J.10
  • 13
    • 0002756339 scopus 로고    scopus 로고
    • Monophosphoryl lipid A (MPL) has TH1 stimulating properties in immunotherapy with birch allergoid
    • Klimek L., B. Stuck, J. Hundorf, S. Schneider-Gene, K. Hörmann: Monophosphoryl lipid A (MPL) has TH1 stimulating properties in immunotherapy with birch allergoid. Allergy 56 (Suppl. 68), 93 (2001).
    • (2001) Allergy , vol.56 , Issue.SUPPL. 68 , pp. 93
    • Klimek, L.1    Stuck, B.2    Hundorf, J.3    Schneider-Gene, S.4    Hörmann, K.5
  • 14
    • 0001760327 scopus 로고
    • Induction of cell-mediated immune responses in man with vaccines against Herpes simplex virus based on glycoprotein D
    • Koutsoukos M., G. Leroux, E.P. Vandepapelier, M. Slaoui, P. Pala: Induction of cell-mediated immune responses in man with vaccines against Herpes simplex virus based on glycoprotein D. 34th ICAAC meeting 1994, M8, 217.
    • (1994) 34th ICAAC meeting , vol.M8 , pp. 217
    • Koutsoukos, M.1    Leroux, G.2    Vandepapelier, E.P.3    Slaoui, M.4    Pala, P.5
  • 17
    • 0343527202 scopus 로고    scopus 로고
    • Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to Herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production
    • Mikloska Z., M. Rückholdt, I. Ghadiminejad, H. Dunckly, M. Denis, A.L. Cunningham: Monophosphoryl lipid A and QS21 increase CD8 T lymphocyte cytotoxicity to Herpes simplex virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production. J. Immunol. 164, 5167-5176 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 5167-5176
    • Mikloska, Z.1    Rückholdt, M.2    Ghadiminejad, I.3    Dunckly, H.4    Denis, M.5    Cunningham, A.L.6
  • 18
    • 0031648808 scopus 로고    scopus 로고
    • Perspective on allogeneic melanoma lysates in active specific immunotherapy
    • Mitchell M.S.: Perspective on allogeneic melanoma lysates in active specific immunotherapy. Semin. Oncol. 25, 623-635 (1998).
    • (1998) Semin. Oncol. , vol.25 , pp. 623-635
    • Mitchell, M.S.1
  • 20
    • 0017370729 scopus 로고
    • Chemical modification of crude timothy grass extract. 3. The effect of glutaraldehyde-induced aggregation on antigenic and immunogenic properties
    • Moran D.M., A.W. Wheeler, B.G. Overell, S.R. Woroniecki: Chemical modification of crude timothy grass extract. 3. The effect of glutaraldehyde-induced aggregation on antigenic and immunogenic properties. Int. Arch. Allergy Appl. Immunol. 54, 315-321 (1977).
    • (1977) Int. Arch. Allergy Appl. Immunol. , vol.54 , pp. 315-321
    • Moran, D.M.1    Wheeler, A.W.2    Overell, B.G.3    Woroniecki, S.R.4
  • 22
    • 0031765186 scopus 로고    scopus 로고
    • Delivery of MUC1 mucin peptide by poly(d,l-lactic-co-glycolic acid)microspheres induces type 1 helper immune responses
    • Newman K.D., D.L. Sowsnowski, G.S. Kwon, J. Samuel: Delivery of MUC1 mucin peptide by poly(d,l-lactic-co-glycolic acid)microspheres induces type 1 helper immune responses. J. Pharm. Sci. 87, 1421-1427 (1998).
    • (1998) J. Pharm. Sci. , vol.87 , pp. 1421-1427
    • Newman, K.D.1    Sowsnowski, D.L.2    Kwon, G.S.3    Samuel, J.4
  • 23
    • 0025735025 scopus 로고
    • Standardisation of glutaraldehyde-modified, tyrosine-adsorbed allergen extracts
    • Overell B.G., D.A. Spackmann, A.W. Wheeler, P. Pfeiffer: Standardisation of glutaraldehyde-modified, tyrosine-adsorbed allergen extracts. Allergologie 14. 110-115 (1991).
    • (1991) Allergologie , vol.14 , pp. 110-115
    • Overell, B.G.1    Spackmann, D.A.2    Wheeler, A.W.3    Pfeiffer, P.4
  • 24
    • 0027443372 scopus 로고
    • Allergen immunotherapy decreases interleukin 4 production in CD4+ cells from allergic individuals
    • Secrist H., C.J. Chelen, Y. Wen, J.D. Marshall, D.T. Umetsu: Allergen immunotherapy decreases interleukin 4 production in CD4+ cells from allergic individuals. J. Exp. Med. 178, 2123-2130 (1993).
    • (1993) J. Exp. Med. , vol.178 , pp. 2123-2130
    • Secrist, H.1    Chelen, C.J.2    Wen, Y.3    Marshall, J.D.4    Umetsu, D.T.5
  • 25
    • 0033922556 scopus 로고    scopus 로고
    • An overview on a novel adjuvanted prophylactic hepatitis B vaccine
    • Thoelen S.: An overview on a novel adjuvanted prophylactic hepatitis B vaccine. Acta Gastroenterol. Belg. 63, 185-186 (2000).
    • (2000) Acta Gastroenterol. Belg. , vol.63 , pp. 185-186
    • Thoelen, S.1
  • 27
    • 0010980039 scopus 로고    scopus 로고
    • Allergen formulation. 1998 World patent (PCT) WO 98/44947
    • Ulrich J.T., A.W. Wheeler: Allergen formulation. 1998 World patent (PCT) WO 98/44947.
    • Ulrich, J.T.1    Wheeler, A.W.2
  • 29
    • 0035208015 scopus 로고    scopus 로고
    • A Th1-inducing adjuvant, MPL, enhances antibody profiles in experimental animals suggesting it has the potential to improve the efficacy of allergy vaccines
    • Wheeler A.W., T. Ulrich, J. Marshall: A Th1-inducing adjuvant, MPL, enhances antibody profiles in experimental animals suggesting it has the potential to improve the efficacy of allergy vaccines. Int. Arch. Allergy Immunol. 126, 135-139 (1998).
    • (1998) Int. Arch. Allergy Immunol. , vol.126 , pp. 135-139
    • Wheeler, A.W.1    Ulrich, T.2    Marshall, J.3
  • 30
    • 0035194832 scopus 로고    scopus 로고
    • Immunological adjuvants in allergy vaccines: Past, present and future
    • Wheeler A.W., S.W. Woroniecki: Immunological adjuvants in allergy vaccines: Past, present and future. Allergol. Int. 50, 295-301 (2001).
    • (2001) Allergol. Int. , vol.50 , pp. 295-301
    • Wheeler, A.W.1    Woroniecki, S.W.2
  • 31
    • 0021920087 scopus 로고
    • Suppression of murine IgE responses with poly-(n-methylglycine)/grass pollen extract conjugates using 4-(methylmercapto)phenyl-succinimidyl succinate as coupling reagent
    • Whittall N., D.M. Moran, A.W. Wheeler, G.P. Cottam: Suppression of murine IgE responses with poly-(n-methylglycine)/grass pollen extract conjugates using 4-(methylmercapto)phenyl-succinimidyl succinate as coupling reagent. Int. Arch. Allergy Appl. Immunol. 76, 354-360 (1985).
    • (1985) Int. Arch. Allergy Appl. Immunol. , vol.76 , pp. 354-360
    • Whittall, N.1    Moran, D.M.2    Wheeler, A.W.3    Cottam, G.P.4


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