Development of a practical, safe, and high-yielding process for the preparation of enantiomerically pure trans-cyclopropane carboxylic acid

Organic Process Research and Development

Volumn 6, Issue 5, 2002, Pages 618-620

  Singh, Ambarish K ^a   Rao, Meena N ^a   Simpson, James H ^a   Li, Wen Sen ^a   Thornton, John E ^a   Kuehner, Daniel E ^a   Kacsur, David J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPROPANECARBOXYLIC ACID DERIVATIVE; EPOXIDE; PHOSPHONOACETIC ACID; REAGENT; SODIUM DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CHIRALITY; CYCLOPROPANATION; ENANTIOMER; SAFETY; SYNTHESIS; TEMPERATURE SENSITIVITY;

EID: 0036747112     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0202033     Document Type: Article

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18. Although DME is a common solvent, appropriate protective measures must be taken when handling DME due to possible teratogenic (target organ: liver, kidneys) and reproductive hazard effects.
19. A peroxide inhibitor (BHT) was added to the DME distillate.