Allopurinol protects enterocytes from hypoxia-induced apoptosis in vivo

Journal of Trauma - Injury, Infection and Critical Care

Volumn 53, Issue 3, 2002, Pages 415-421

  Albuquerque, Ronald G ^a   Sanson, Angela J ^a   Malangoni, Mark A ^a   Choo, Daryl ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allopurinol; Apoptosis; Hypoxia; Xanthine oxidase

Indexed keywords

ALLOPURINOL; DNA FRAGMENT; NITROGEN; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CELL HYPOXIA; CELL PROTECTION; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; INTESTINE CELL; INTESTINE VILLUS; JEJUNUM; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RANK SUM TEST; RAT;

EID: 0036740466     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/00005373-200209000-00003     Document Type: Conference Paper

References (23)

1. Shimizu S, Eguchi Y, Kamiike W, et al. Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL. Cancer Res. 1996;56:2161-2166.
2. Poss WB, Huecksteadt TP, Panus PC, Freeman BA, Hoidal JR. Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia. Am J Physiol. 1996;270:L941-L946.
3. Okur H, Kucukaydin M, Kose K, Kontas O, Dogam P, Kazez A. Hypoxia-induced necrotizing enterocolitis in the immature rat: the role of lipid peroxidation and management by vitamin E. J Pediatr Surg. 1995;30:1416-1419.
4. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985;312:159-163.
5. Hockenbery DM. bcl-2, a novel regulator of cell death. Bioessays. 1995;17:631-638.
6. Grossmann J, Maxson JM, Whitacre CM, et al. New isolation technique to study apoptosis in human intestinal epithelial cells. Am J Pathol. 1998;153:53-62.
7. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493-501.
8. Parks DA, Williams TK, Beckman JS. Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: a reevaluation. Am J Physiol. 1988;254:G768-G774.
9. Hirata Y, Taguchi T, Nakao M, Yamada T, Hirose R, Suita S. The relationship between the adenine nucleotide metabolism and the conversion of the xanthine oxidase enzyme system in ischemia-reperfusion of the rat small intestine. J Pediatr Surg. 1996;31:1199-1204.
10. Parks DA, Granger DN. Xanthine oxidase: biochemistry, distribution and physiology. Acta Physiol Scand Suppl. 1986;548:87-99.
11. Granger DN, Rutili G, McCord JM. Superoxide radicals in feline intestinal ischemia. Gastroenterology. 1981;81:22-29.
12. Tan S, Yokoyama Y, Dickens E, Cash TG, Freeman BA, Parks DA. Xanthine oxidase activity in the circulation of rats following hemorrhagic shock. Free Radic Biol Med. 1993;15:407-414.
13. Terada LS, Dormish JJ, Shanley PF, Leff JA, Anderson BO, Repine JE. Circulating xanthine oxidase mediates lung neutrophil sequestration after intestinal ischemia-reperfusion. Am J Physiol. 1992;263:L394-L401.
14. Grisham MB, Hernandez LA, Granger DN. Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Am J Physiol. 1986;251:G567-G574.
15. Pinault GC, Sanson AJ, Malangoni MA, Inhibition of xanthine oxidase does not influence immunosuppression after hemorrhagic shock. J Trauma. 1997;43:911-915.
16. Rollwagen FM, Yu ZY, Li YY, Pacheco ND. IL-6 rescues enterocytes from hemorrhage induced apoptosis in vivo and in vitro by a bcl-2 mediated mechanism. Clin Immunol Immunopathol. 1998;89:205-213.
17. Terada LS, Piermattei D, Shibao GN, McManaman JL, Wright RM. Hypoxia regulates xanthine dehydrogenase activity at pre- and posttranslational levels. Arch Biochem Biophys. 1997;348:163-168.
18. Kayyali US, Donaldson C, Huang H, Abdelnour R, Hassoun PM. Phosphorylation of xanthine dehydrogenase/oxidase in hypoxia. J Biol Chem. 2001;276:14359-14365.
19. Wang H, Ma L, Li Y, Cho CH. Exposure to cigarette smoke increases apoptosis in the rat gastric mucosa through a reactive oxygen species-mediated and p53-independent pathway. Free Radic Biol Med. 2000;28:1125-1131.
20. Shah KA, Shurey S, Green CJ. Characterization of apoptosis in intestinal ischaemia-reperfusion injury: a light and electron microscopic study. Int J Exp Pathol. 1997;78:355-363.
21. Motoyama S, Minamiya Y, Saito S, et al. Hydrogen peroxide derived from hepatocytes induces sinusoidal endothelial cell apoptosis in perfused hypoxic rat liver. Gastroenterology. 1998;114:153-163.
22. Klein AS, Joh JW, Rangan U, Wang D, Bulkley GB. Allopurinol: discrimination of antioxidant from enzyme inhibitory activities. Free Radic Biol Med. 1996;21:713-717.
23. Aloprim (allopurinol sodium, Nabi Biopharmaceuticals) for injection, prescribing information, June 1999.