Expression of foreign LpxA acyltransferases in Neisseria meningitidis results in modified lipid A with reduced toxicity and retained adjuvant activity

Cellular Microbiology

Volumn 4, Issue 9, 2002, Pages 599-611

  Steeghs, Liana ^a,b,c   Berns, Mariska ^a   Hove, Jan Ten ^a   De Jong, Ad ^a   Roholl, Paul ^a   Van Alphen, Loek ^a   Tommassen, Jan ^b   Van Der Ley, Peter ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c Laboratory of Vaccine Research   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ADJUVANT; ANTIBIOTIC AGENT; BACITRACIN; BACTERIAL VACCINE; BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; ERYTHROMYCIN; FATTY ACID; KANAMYCIN; LIPID A; NOVOBIOCIN; OUTER MEMBRANE PROTEIN; RIFAMPICIN; TETRACYCLINE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; CONTROLLED STUDY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IMMUNOGENICITY; LIPID COMPOSITION; MOUSE; MOUSE STRAIN; NEISSERIA MENINGITIDIS; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PSEUDOMONAS AERUGINOSA; SEQUENCE HOMOLOGY; TOXICITY TESTING; WILD TYPE;

ACYLTRANSFERASES; ADJUVANTS, IMMUNOLOGIC; BACITRACIN; FATTY ACIDS; GENE TRANSFER TECHNIQUES; LIPID A; MENINGOCOCCAL VACCINES; NEISSERIA MENINGITIDIS; NOVOBIOCIN; RECOMBINANT PROTEINS; RIFAMPIN; TETRACYCLINE; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; NEISSERIA; NEISSERIA MENINGITIDIS; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0036740455     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2002.00214.x     Document Type: Article

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