Paracetamol toxicity: Epidemiology, prevention and costs to the health-care system

QJM: An International Journal of Medicine

Volumn 95, Issue 9, 2002, Pages 609-619

  Sheen, C L ^a,d   Dillon, J F ^a   Bateman, D N ^b   Simpson, K J ^c   Macdonald, T M ^a  

^a NINEWELLS HOSPITAL   (United Kingdom)

^b Scottish Poisons Information Bureau   (United Kingdom)

^c ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANALGESIC AGENT; ANTIHISTAMINIC AGENT; ANTIPYRETIC AGENT; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; GLUTATHIONE; HOMOCYSTEINE; IBUPROFEN; METHIONINE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PARADOTE; PLACEBO; ROFECOXIB; TERFENADINE;

ADULT; ARTICLE; CARCINOGENESIS; CHILD; CONTROLLED STUDY; COST OF ILLNESS; DROWSINESS; DRUG INTOXICATION; DRUG MISUSE; DRUG OVERDOSE; GASTROINTESTINAL HEMORRHAGE; HEALTH CARE COST; HEART ARRHYTHMIA; HUMAN; INCIDENCE; LEGAL ASPECT; MORBIDITY; MORTALITY; PAIN; PRESCRIPTION; PRIORITY JOURNAL; SELF POISONING;

EID: 0036736003     PISSN: 14602725     EISSN: None     Source Type: Journal    
DOI: 10.1093/qjmed/95.9.609     Document Type: Article

References (161)

1. The history and usage of paracetamol
2. Paracetamol sales and atopic disease in children and adults: An ecological analysis
3. Liver damage and impaired glucose tolerance after paracetamol overdosage
4. Acute liver necrosis following overdose of paracetamol
5. The PAIN Study: Paracetamol, aspirin and ibuprofen new tolerability study
6. Comparative efficacy of aspirin and acetaminophen in the reduction of fever in children
7. Comparative evaluation of the antipyretic efficacy of ibuprofen and paracetamol
8. Antipyretic efficacy of ibuprofen vs. acetaminophen
9. Comparing efficacy and tolerability of ibuprofen and paracetamol in fever
10. Ibuprofen, acetaminophen, and placebo treatment of febrile children
11. Acetaminophen has greater antipyretic efficacy than aspirin in endotoxemia: A randomized, double-blind, placebo-controlled trial
12. A comparison of nimesulide vs paracetamol in the treatment of pyrexia in the elderly
13. Fever in uncomplicated Plasmodium falciparum infection: Effects of quinine and paracetamol
14. Antipyretic efficacy of indomethacin and acetaminophen in uncomplicated falciparum malaria
15. Effects of acetaminophen on adverse effects of influenza vaccination in health-care workers
16. A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children
17. Variation in surgical trauma and baseline pain intensity: Effects on assay sensitivity of an analgesic trial
18. Rectal paracetamol has a significant morphine-sparing effect after hysterectomy
19. Analgesic efficacy and the tolerance for piroxicam-beta-cyclodextrin compared to piroxicam, paracetamol and placebo in the treatment of postextraction dental pain
20. Morphine-sparing effect of acetaminophen in pediatric day-case surgery
21. Analgesia for circumcision: Effects on newborn behavior and mother/infant interaction
22. Comparative study of ibuprofen lysine and acetaminophen in patients with postoperative dental pain
23. A comparison of the hypoalgesic effect of paracetamol in slow-release and plain tablets on laser-induced pain
24. A placebo-controlled model for assaying systemic analgesics in children
25. Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain
26. The efficacy of ketoprofen and paracetamol (acetaminophen) in postoperative pain after third molar surgery
27. Analgesic efficacy of acetaminophen 1000 mg, acetaminophen 2000 mg, and the combination of acetaminophen 1000 mg and codeine phosphate 60 mg versus placebo in acute postoperative pain
28. Effects of rectally administered paracetamol on infants delivered by vacuum extraction
29. Effectiveness of Oleum menthae piperitae and paracetamol in therapy of headache of the tension type
30. Treatment of migraine attacks: Combination of dihydroergotamine tartrate and paracetamol in comparison with individual drugs and placebo
31. Efficacy and safety of acetaminophen in the treatment of migraine: Results of a randomized, double-blind, placebo-controlled, population-based study
32. Solubilized ibuprofen: Evaluation of onset, relief, and safety of a novel formulation in the treatment of episodic tension-type headache
33. Headache pain model for assessing and comparing the efficacy of over-the-counter analgesic agents
34. Ketoprofen (25 mg) in the symptomatic treatment of episodic tension-type headache: Double-blind placebo-controlled comparison with acetaminophen (1000 mg)
35. Postoperative analgesia with preoperative oral ibuprofen or acetaminophen in children undergoing myringotomy
36. Prophylactic paracetamol for analgesia after vaginal termination of pregnancy
37. Paracetamol 1 g given rectally at the end of minor gynaecological surgery is not efficacious in reducing postoperative pain
38. Treatment of acute inflammatory pathology of the upper airway with morniflumate
39. Analgesic efficacy of acetaminophen sustained release
40. Effectiveness of various medications on postoperative pain following root canal obturation
41. Change in pain threshold by meperidine, naproxen sodium, and acetaminophen as determined by electric pulp testing
42. Analgesic efficacy of immediate and sustained release paracetamol and plasma concentration of paracetamol: Double-blind, placebo-controlled evaluation using painful laser stimulation
43. Dose-related effects of oral acetaminophen on cold-induced pain: A double-blind, randomized, placebo-controlled trial
44. Double-blind, placebo controlled comparison of paracetamol and paracetamol plus codeine: A quantitative evaluation by laser induced pain
45. Acetaminophen or ketorolac for post myringotomy pain in children? A prospective, double-blinded comparison
46. Analgesic effect of ibuprofen in pain after episiotomy
47. A prospective, randomized comparison of dexketoprofen, ketoprofen or paracetamol for postoperative analgesia after outpatient knee arthroscopy
48. Additive analgesic effect of codeine and paracetamol can be detected in strong, but not moderate, pain after Caesarean section: Baseline pain intensity is a determinant of assay-sensitivity in a postoperative analgesic trial
49. Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: A randomized, double-blind single-dose study
50. Comparative trial of lysine acetylsalicylate and paracetamol on pain in daily medical practice
51. Otorhinolaryngologic pain in the adult: A comparison of the analgesic efficacy of lysine acetylsalicylate and paracetamol
52. Comparative, randomized, parallel clinical study of the effectiveness and safety of aceclofenac vs. paracetamol in the treatment of viral pharyngoamygdalitis
53. Analgesic efficacy of flurbiprofen in comparison with acetaminophen, acetaminophen plus codeine, and placebo after impacted third molar removal
54. Painless dental extraction in children
55. Evaluation of ketorolac, ibuprofen, acetaminophen, and an acetaminophen-codeine combination in postoperative oral surgery pain
56. The effect of food on bromfenac, naproxen sodium, and acetaminophen in postoperative pain after orthopedic surgery
57. A single-dose, double-blind comparison of naproxen sodium, acetaminophen, and placebo in postoperative dental pain
58. Morphine consumption in patients receiving rectal paracetamol and diclofenac alone and in combination
59. Ketorolac versus acetaminophen or ibuprofen in controlling postoperative pain in patients with strabismus
60. Double-blind randomized study of tramadol vs. paracetamol in analgesia after day-case tonsillectomy in children
61. Postoperative analgesia at home after ambulatory hand surgery: A controlled comparison of tramadol, metamizol, and paracetamol
62. Comparison of the analgesic effects of diflunisal and paracetamol in the treatment of postoperative dental pain
63. The efficacy of amitriptyline and acetaminophen in the management of acute low back pain
64. Ketoprofen, acetaminophen plus oxycodone, and acetaminophen in the relief of postoperative pain
65. Analgesia after bilateral myringotomy and placement of pressure equalization tubes in children: Acetaminophen versus acetaminophen with codeine
66. Perioperative effects of oral ketorolac and acetaminophen in children undergoing bilateral myringotomy
67. Ketoprofen, paracetamol and placebo in the treatment of episodic tension-type headache
68. Evaluating codeine plus paracetamol for pain
69. Randomized double-blind comparison of tolfenamic acid and paracetamol in migraine
70. Floctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs. Franco-Belgian Task Force
71. Ketoprofen, acetaminophen, and placebo in the treatment of tension headache
72. A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee
73. Nonprescription ibuprofen and acetaminophen in the treatment of tension-type headache
74. Prevention and control of pain in (adeno)tonsillectomy
75. Pain control with paracetamol from a sustained release formulation and a standard release formulation after third molar surgery: A randomised controlled trial
76. Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories
77. Strabismus surgery in children: The effect of paracetamol and bupivacaine
78. Lysine clonixinate in minor dental surgery: Double-blind randomized parallel study versus paracetamol
79. Bromfenac, acetaminophen, and placebo in orthopedic postoperative pain
80. Acetaminophen versus acetaminophen with codeine after pediatric tonsillectomy
81. Time to onset of analgesia and analgesic efficacy of effervescent acetaminophen 1000 mg compared to tablet acetaminophen 1000 mg in postoperative dental pain: A single-dose, double-blind, randomized, placebo-controlled study
82. Comparison of postoperative emesis, recovery profile, and analgesia in pediatric strabismus repair: Rectal acetaminophen versus intravenous fentanyl-droperidol
83. An assessment of the efficacy and tolerability of nimesulide vs. paracetamol in children after adenotonsillectomy
84. A comparison of nimesulide and paracetamol in the treatment of fever due to inflammatory diseases of the upper respiratory tract in children
85. Comparison of the efficacy of paracetamol versus paracetamol, codeine and promethazine (Painstop) for premedication and analgesia for myringotomy in children
86. Oxycodone versus paracetamol in oral premedication in cholecystectomy
87. Tenoxicam for pain relief following third molar surgery
88. A double-blind evaluation of ketorolac tromethamine versus acetaminophen in pediatric tonsillectomy: Analgesia and bleeding
89. Analgesic efficacy and safety of (R)-ketoprofen in postoperative dental pain
90. Diclofenac or acetaminophen for analgesia in paediatric tonsillectomy outpatients
91. Preoperative rectal diclofenac versus paracetamol for tonsillectomy: Effects on pain and blood loss
92. Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee
93. Treatment of knee osteoarthritis: Relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic
94. Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee
95. Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis
96. Managing delayed-onset muscle soreness: Lack of effect of selected oral systemic analgesics
97. The pharmacokinetics and analgesic efficacy of larger dose rectal acetaminophen (40 mg/kg) in adults: A double-blinded, randomized study
98. Prophylactically-administered rectal acetaminophen does not reduce postoperative opioid requirements in infants and small children undergoing elective cleft palate repair
99. Tube placement: A prospective, randomized double-blind study
100. The effect of paracetamol, fentanyl, and systematic assessments on children's pain after tonsillectomy and adenoidectomy
101. Acetaminophen analgesia in neonatal circumcision: The effect on pain
102. Overexertional lumbar and thoracic back pain among recruits: A prospective study of risk factors and treatment regimens
103. Pharmacokinetics of oral diclofenac and acetaminophen in children after surgery
104. Comparison of preoperative ibuprofen, acetaminophen, and placebo administration on the parental report of postextraction pain in children
105. A double-blind placebo-controlled study to assess the efficacy of a compound analgesic to prevent postoperative pain following oral surgery
106. Randomised controlled trial of paracetamol for heel prick pain in neonates
107. Examination of acetaminophen for outpatient management of post-operative pain in children
108. Single-dose paracetamol (acetaminophen), with and without codeine, for postoperative pain
109. The epidemiology of acute acetaminophen poisoning in England and Wales
110. Paracetamol self-poisoning: Characteristics, prevention and harm reduction
111. Trends in deliberate self-poisoning and self-injury in Oxford, 1976-90
112. Consumption, overdose and death from analgesics during a period of over-the-counter availability of paracetamol in Denmark
113. Paracetamol overdose in a liver transplantation centre: An 8-year experience
114. Hospitalisation for deliberate self-poisoning in Scotland from 1981 to 1993: Trends in rates and types of drugs used
115. Differences between general practices in hospital admission rates for self-inflicted injury and self-poisoning: Influence of socioeconomics factors
116. Hepatotoxicity from paracetamol self-poisoning in western Sydney: A continuing challenge
117. A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993)
118. Paracetamol related deaths in England and Wales, 1993-97
119. Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine
120. Pediatric poisonings
121. Pediatric acetaminophen overdose: Risk factors associated with hepatocellular injury
122. Acetaminophen toxicity in an urban county hospital
123. Treatment of acetaminophen overdose
124. Are suicide rates in Sweden associated with changes in the prescribing of medicines?
125. Use of paracetamol for suicide and non-fatal poisoning in the UK and France: Are restrictions on availability justified?
126. Why do people use paracetamol for suicide?
127. Why patients choose paracetamol for self poisoning and their knowledge of its dangers
128. Paracetamol use, availability, and knowledge of toxicity among British and American adolescents
129. Effects of a drug overdose in a television drama on presentations to hospital for self-poisoning: Time series and questionnaire study
130. Reporting suicide: The effect of media coverage on patterns of self-harm
131. Effects of a drug overdose in a television drama on knowledge of specific dangers of self-poisoning: Population based surveys
132. Paracetamol and aspirin
133. Reduction in incidence of severe paracetamol poisoning
134. Change in occurrence of paracetamol overdose in UK after introduction of blister packs
135. Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: Before and after study
136. Severity of overdose after restriction of paracetamol availability: Retrospective study
137. The effect on toxicity on reducing the size of available paracetamol pack sizes
138. Referral patterns and social deprivation in paracetamol-induced liver injury in Scotland
139. Letter: Prevention of paracetamol poisoning
140. Paracetamol + methionine: Pameton
141. Comparison of a traditional paracetamol medication and a new paracetamol/paracetamol-methionine ester combination
142. Cysteamine, methionine, and penicillamine in the treatment of paracetamol poisoning
143. The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures
144. Should methionine be added to every paracetamol tablet?
145. Acute hyperhomocysteinaemia and endothelial dysfunction
146. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men
147. Serum total homocysteine and coronary heart disease
148. Effects of methionine-induced hyperhomocysteinemia on endothelium- dependent vasodilation and oxidative status in healthy adults
149. Homocysteine levels during fasting and after methionine loading in adolescents with diabetic retinopathy and nephropathy
150. Fluctuations in dietary methionine intake do not alter plasma homocysteine concentration in healthy Men
151. Association between non-steroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: An overview of epidemiologic studies published in the 1990s
152. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: A randomized controlled trial
153. Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs
154. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: A randomized controlled trial
155. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis
156. Risk of cardiovascular events associated with selective COX-2 inhibitors
157. Cardiovascular and renal effects of COX-2-specific inhibitors: Recent insights and evolving clinical implications
158. Costs of poison-related hospitalization at an urban teaching hospital for children
159. The human and economic cost of paracetamol (acetaminophen) overdose
160. The effect on toxicity and healthcare costs on reducing the size of available acetaminophen pack sizes in the Tayside region of Scotland