Serum concentrations of cartilage oligomeric matrix protein, fibrinogen and hyaluronan distinguish inflammation and cartilage destruction in experimental arthritis in rats

Rheumatology

Volumn 41, Issue 9, 2002, Pages 996-1000

  Larsson, E ^a   Harris, H Erlandsson ^a   Lorentzen, J C ^a   Larsson, A ^b   Mansson B ^c   Klareskog, L ^a   Saxne, T ^c  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Cartilage oligomeric matrix protein; Collagen induced arthritis; Experimental autoimmune encephalomyelitis; Fibrinogen; Hyaluronan; Oil induced arthritis

Indexed keywords

BIOLOGICAL MARKER; CARTILAGE OLIGOMERIC MATRIX PROTEIN; COLLAGEN; FIBRINOGEN; HYALURONIC ACID; OIL;

ALLERGIC ENCEPHALITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; CARTILAGE DEGENERATION; CONTROLLED STUDY; DISEASE COURSE; DISEASE MARKER; IMMUNIZATION; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SYNOVITIS;

ANIMALS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EXTRACELLULAR MATRIX PROTEINS; FIBRINOGEN; GLYCOPROTEINS; HYALURONIC ACID; MALE; RATS; RATS, INBRED STRAINS; SEVERITY OF ILLNESS INDEX; SYNOVITIS;

EID: 0036733496     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Deforming arthropathy of the hands in systemic lupus erythematosus
2. The relationship between synovitis and erosions in rheumatoid arthritis
3. Markers of disease in rheumatoid arthritis
4. Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage
5. Cartilage oligomeric matrix protein (COMP) is an abundant component of tendon
6. The distribution of cartilage oligomeric matrix protein (COMP) in tendon and its variation with tendon site, age and load
7. Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation
8. Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular chondrocytes
9. Molecular markers for assessment of cartilage damage in rheumatoid arthritis
10. Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats
11. Increased serum levels of cartilage oligomeric matrix protein and bone sialoprotein in rats with collagen arthritis
12. IL-1 blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF blockade only ameliorates joint inflammation
13. Elevated levels of serum hyaluronate and correlation with disease activity in experimental models of arthritis
14. Circulating hyaluronic acid levels vary with physical activity in healthy subjects and in rheumatoid arthritis patients. Relationship to synovitis mass and morning stiffness
15. Nephelometric determination of rat fibrinogen as a marker of inflammatory response
16. Autoimmunity to type II collagen, an experimental model of arthritis
17. Homologous type II collagen-induced arthritis in rats. Characterization of the disease and demonstration of clinically distinct forms of arthritis in two strains of rats after immunization with the same collagen preparation
18. Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement
19. Analysis of type II collagen-reactive T cells in the mouse. I. Different regulation of autoreactive vs. non-autoreactive anti-type II collagen T cells in the DBA/1 mouse
20. Nature of the collagen synthesized by a transplanted chondrosarcoma
21. Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant
22. Cartilage oligomeric matrix protein: A novel marker of cartilage turnover detectable in synovial fluid and blood (published erratum appears in Br J Rheumatol 1993;32:247)
23. A convenient radiometric assay for hyaluronan