Synthesis and cyclic AMP phosphodiesterase 4 isoenzyme inhibitory activity of heterocycle condensed purines

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 9, 2002, Pages 1163-1168

  Suzuki, Hirokazu ^a   Yamamoto, Manabu ^c   Shimura, Susumu ^c   Miyamoto, Ken Ichi ^b   Yamamoto, Kenji ^a   Sawanishi, Hiroyuki ^a  

^a HOKURIKU UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c Lotte Co Ltd   (Japan)

Author keywords

Heterocycle condensed purine; PDE4 inhibitor; Tetrahydro imidazo 2,1 i purine

Indexed keywords

1 BUTYL 3 PROPYLXANTHINE; 1,4 DIPROPYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[1,2 A]PURIN 10 ONE; 1,4 DIPROPYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[1,2 A]PURIN 9 ONE; 10 PROPYL 4,5 DIHYDRO 10H DIAZEPINO[1,2,3 C,D]PURINE 9,11 DIONE; 2 (HYDROXYETHYLAMINO) 3 PROPYLPURIN 6 ONE; 2 (HYDROXYPROPYLAMINO) 3 PROPYLPURIN 6 ONE; 2 METHYLTHIO 3 PROPYLPURIN 6 ONE; 3 BENZYL 5 PROPYL 5,6,7,8 TETRAHYDRO 3H IMIDAZO[2,1 B]PURINE 4 ONE; 3,5 DIPROPYL 5,6,7,8 TETRAHYDRO 3H IMIDAZO[2,1 B]PURINE 4 ONE; 3,5 DIPROPYL 5,6,7,8 TETRAHYDRO 3H PYRIMIDO[2,1 B]PURINE 4 ONE; 4 PROPYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[1,2 A]PURIN 10 ONE; 4 PROPYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[1,2 A]PURIN 9 ONE; 4,5 DIHYDRO 10H DIAZEPINO[1,2,3 C,D]PURINE 9,11 DIONE; 4,5 DIHYDRO 9H PYRIMIDO[1,2,3 C,D]PURINE 8,10 DIONE; 7 BENZYL 2 (HYDROXYETHYLAMINO) 1 PROPYLPURIN 6 ONE; 7 BENZYL 2 (HYDROXYPROPYLAMINO) 1 PROPYLPURIN 6 ONE; 9 PROPYL 4,5 DIHYDRO 9H PYRIMIDO[1,2,3 C,D]PURINE 8,10 DIONE; DENBUFYLLINE; DEXTRO LEVO 1,4 DIPROPYL 7 METHYL 4,5,6,7 TETRAHYDRO 3H IMIDAZO[2,1 I]PURIN 5 ONE; DEXTRO LEVO 1,4 DIPROPYL 8 METHYL 4,5,6,7 TETRAHYDRO 3H IMIDAZO[2,1 I]PURIN 5 ONE; DEXTRO LEVO 3,4 DIPROPYL 7 METHYL 4,5,6,7 TETRAHYDRO 3H IMIDAZO[2,1 I]PURIN 5 ONE; DEXTRO LEVO 3,4 DIPROPYL 8 METHYL 4,5,6,7 TETRAHYDRO 3H IMIDAZO[2,1 I]PURIN 5 ONE; DEXTRO LEVO 4 PROPYL 7 METHYL 4,5,6,7 TETRAHYDRO 3H IMIDAZO[2,1 I]PURIN 5 ONE; DEXTRO LEVO 4 PROPYL 8 METHYL 4,5,6,7 TETRAHYDRO 3H IMIDAZO[2,1 I]PURIN 5 ONE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV; PROPYL 5,6,7,8 TETRAHYDRO 3H IMIDAZO[2,1 B]PURINE 4 ONE; PROPYL 5,6,7,8 TETRAHYDRO 3H PYRIMIDO[2,1 B]PURINE 4 ONE; PURINE DERIVATIVE; ROLIPRAM; UNCLASSIFIED DRUG; UNINDEXED DRUG; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; HETEROCYCLIC COMPOUND; ISOENZYME; PHOSPHODIESTERASE; PHOSPHODIESTERASE I;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; POLYMERIZATION; DRUG ANTAGONISM; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; SYNTHESIS;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; CHEMISTRY, PHYSICAL; HETEROCYCLIC COMPOUNDS; INDICATORS AND REAGENTS; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PURINES;

EID: 0036728480     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.1163     Document Type: Article

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