Transforming properties of a Q18→E mutation of the microtubule regulator Op18

Cancer Cell

Volumn 2, Issue 3, 2002, Pages 217-228

  Misek, David E ^a   Chang, Christina L ^a   Kuick, Rork ^a   Hinderer, Robert ^a   Giordano, Thomas J ^a   Beer, David G ^a   Hanash, Samir M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOSINE; GUANINE; ONCOPROTEIN 18; PROTEIN; TUBULIN; UNCLASSIFIED DRUG; MICROTUBULE PROTEIN; PHOSPHOPROTEIN; STATHMIN; STMN1 PROTEIN, HUMAN; STMN1 PROTEIN, MOUSE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; GENE OVEREXPRESSION; GENE SEQUENCE; IMMUNE DEFICIENCY; INDUCED MUTATION; MICROTUBULE ASSEMBLY; MITOSIS INDEX; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SOMATIC MUTATION; TUMOR GROWTH; ADENOCARCINOMA; ANIMAL; CELL DIVISION; CELL STRAIN 3T3; CELL TRANSFORMATION; ESOPHAGUS TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; METABOLISM; MICROTUBULE; NEOPLASM; PATHOLOGY; PHOSPHORYLATION; POINT MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TWO DIMENSIONAL GEL ELECTROPHORESIS; ULTRASTRUCTURE; WESTERN BLOTTING;

3T3 CELLS; ADENOCARCINOMA; ANIMALS; BLOTTING, WESTERN; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ESOPHAGEAL NEOPLASMS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICE; MICROTUBULE PROTEINS; MICROTUBULES; NEOPLASMS; PHOSPHOPROTEINS; PHOSPHORYLATION; POINT MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATHMIN; TUBULIN;

EID: 0036727679     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-6108(02)00124-1     Document Type: Article

References (38)

1. Belmont, L.D., and Mitchison, T.J. (1996). Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. Cell 84, 623-631.
2. Beretta, L., Dobránsky, T., and Sobel, A. (1993). Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2. J. Biol. Chem. 268, 20076-20084.
3. Brattsand, G., Roos, G., Marklund, U., Ueda, H., Landberg, G., Nanberg, E., Sideras, P., and Gullberg, M. (1993). Quantitative analysis of the expression and regulation of an activation-regulated phosphoprotein (oncoprotein 18) in normal and neoplastic cells. Leukemia 7, 569-579.
4. Brattsand, G., Marklund, U., Nylander, K., Roos, G., and Gullberg, M. (1994). Cell cycle regulated phosphorylation of oncoprotein 18 on Ser16, Ser25, and Ser38. Eur. J. Biochem. 20, 359-368.
5. Coleman, T.R., and Dunphy, W.G. (1994). Cdc2 regulatory factors. Curr. Opin. Cell Biol. 6, 877-882.
6. Cooper, H.L., McDuffie, E., and Braverman, R. (1989). Human peripheral lymphocyte growth regulation and response to phorbol esters is linked to synthesis and phosphorylation of the cytosolic protein, prosolin. J. Immunol. 143, 956-963.
7. Curmi, P.A., Maucuer, A., Asselin, S., Lecourtois, M., Chaffotte, A., Schmitter, J.M., and Sobel, A. (1994). Molecular characterization of human stathmin expressed in Escherichia coli: site-directed mutagenesis of two phosphorylatable serines (Ser-25 and Ser-63). Biochem. J. 300, 331-338.
8. Curmi, P.A., Nogues, C., Lachkar, S., Carelle, N., Gonthier, M.P., Sobel, A., Lidereau, R., and Bieche, I. (2000). Overexpression of stathmin in breast carcinomas points out to highly proliferative tumours. Br. J. Cancer 82, 42-50.
9. Farabegoli, F., Ceccarelli, C., Santini, D., Trere, D., Baldini, N., Taffurelli, M., and Derenzini, M. (1996). Chromosome 1 aneusomy with 1p36 under-representation is related to histologic grade, DNA aneuploidy, high c-erb B-2 and loss of bcl-2 expression in ductal breast carcinoma. Int. J. Cancer 69, 381-385.
10. Ferrari, A.C., Seuanez, H.M., Hanash, S.M., and Atweh, G.F. (1990). A gene that encodes for a leukemia-associated phosphoprotein (p18) maps to chromosome band 1p35-36.1. Genes Chromosomes Cancer 2, 125-129.
11. Gavet, O., Ozon, S., Manceau, V., Lawler, S., Curmi, P., and Sobel, A. (1998). The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. J. Cell Sci. 111, 3333-3346.
12. Hailat, N., Strahler, J., Melhem, R., Zhu, X.X., Brodeur, G., Seeger, R.C., Reynolds, C.P., and Hanash, S.M. (1990). N-myc gene amplification in neuroblastoma is associated with altered phosphorylation of a proliferation related polypeptide (Op18). Oncogene 5, 1615-1618.
13. Hanash, S.M., Strahler, J.R., Kuick, R., Chu, E.H.Y., and Nichols, D. (1988). Identification of a polypeptide associated with the malignant phenotype in acute leukemia. J. Biol. Chem. 263, 12813-12815.
14. Horwitz, S.B., Shen, H.J., He, L., Dittmar, P., Neef, R., Chen, J., and Schubart, U.K. (1997). The microtubule-destabilizing activity of metablastin (p19) is controlled by phosphorylation. J. Biol. Chem. 272, 8129-8132.
15. Johnston, R.F., Pickett, S.C., and Barker, D.L. (1990). Autoradiography using storage phosphor technology. Electrophoresis 11, 355-360.
16. Jourdain, L., Curmi, P., Sobel, A., Pantaloni, D., and Carlier, M.F. (1997). Stathmin: a tubulin-sequencing protein which forms a ternary T2S complex with two tubulin molecules. Biochemistry 36, 10817-10821.
17. Kuick, R., Hanash, S.M., Chu, E.H.Y., and Strahler, J.R. (1987). A comparison of some adjustment techniques for use with quantitative spot data. Electrophoresis 8, 199-204.
18. Kuntziger, T., Gavet, O., Sobel, A., and Bornens, M. (2001). Differential effect of two stathmin/Op18 phosphorylation mutants on xenopus embryo development. J. Biol. Chem. 276, 22979-22984.
19. Lacey, K.R., Jackson, P.K., and Stearns, T. (1999). Cyclin-dependent kinase control of centrosome duplication. Proc. Natl. Acad. Sci. USA 96, 2817-2822.
20. Larsson, N., Melander, H., Marklund, U., Osterman, Ö., and Gullberg, M. (1995). G2/M transition requires multisite phosphorylation of oncoprotein 18 by two distinct protein kinase systems. J. Biol. Chem. 23, 14175-14183.
21. Larsson, N., Marklund, U., Gradin, H.M., Brattsand, G., and Gullberg, M. (1997). Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis. Mol. Cell. Biochem. 17, 5530-5539.
22. Luo, X.-N., Mookerjee, B., Ferrari, A., Mistry, S., and Atweh, G. (1994). Regulation of phosphoprotein p18 in leukemic cells. Cell cycle regulated phosphorylation by p34cdc2 kinase. The J. Biol. Chem. 269, 10312-10318.
23. Marklund, U., Brattsand, G., Shingler, V., and Gullberg, M. (1993). Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. J. Biol. Chem. 268, 15039-15047.
24. Marklund, U., Larsson, N., Brattsand, G., Osterman, O., Chatila, T.A., and Gullberg, M. (1994). Serine 16 of oncoprotein 18 is a major cytosolic target for the Ca2+/calmodulin-dependent kinase-Gr. Eur. J. Biochem. 225, 53-60.
25. Marklund, U., Larsson, N., Gradin, H.M., Brattsand, G., and Gullberg, M. (1996). Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics. EMBO J. 15, 5290-5298.
26. Maucuer, A., Camonis, J.H., and Sobel, A. (1995). Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc. Natl. Acad. Sci. USA 92, 3100-3104.
27. Melander Gradin, H., Marklund, U., Larsson, N., Chatila, T.A., and Gullberg, M. (1997). Regulation of microtubule dynamics by Ca2+/calmodulin- dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18. Mol. Cell. Biol. 17, 3459-3467.
28. Melhem, R.F., Zhu, X.X., Hailat, N., Strahler, J., and Hanash, S.M. (1991). Characterization of the gene for a proliferation related phosphoprotein (Op18) expressed in high amounts in acute leukemia. J. Biol. Chem. 266, 17747-17753.
29. Roos, G., Brattsand, G., Landberg, G., Marklund, U., and Gullberg, M. (1993). Expression of oncoprotein 18 in human leukemias and lymphomas. Leukemia 7, 1538-1546.
30. Rowlands, D.C., Williams, A., Jones, N.A., Guest, S.S., Reynolds, G.M., Barber, P.C., and Brown, G. (1995). Stathmin expression is a feature of proliferating cells of most, if not all, cell lineages. Lab. Invest. 72, 100-113.
31. Sobel, A. (1991). Stathmin: a relay phosphoprotein for multiple signal transduction? Trends Biochem. Sci. 16, 301-305.
32. Strahler, J.R., Kuick, R., and Hanash, S.M. (1989). Two-dimensional polyacrylamide gel electrophoresis of proteins. In Protein Structure: A Practical Approach, T. Creighton, ed. (Oxford: IRL Press Ltd.), pp. 65-92.
33. Strahler, J.R., Hailat, N., Lamb, B.J., Rogers, K.P., Underhill, J.A., Melhem, R.F., Keim, D.R., Zhu, X.-X., Kuick, R.D., Fox, D.A., and Hanash, S.M. (1992a). Activation of resting peripheral blood lymphocytes through the T cell receptor induces rapid phosphorylation of Op18. J. Immunol. 149, 1191-1198.
34. Strahler, J.R., Lamb, B.J., Ungar, D.R., Fox, D.A., and Hanash, S.M. (1992b). Cell cycle progression is associated with distinct patterns of phosphorylation of Op18. Biochem. Biophys. Res. Commun. 185, 197-203.
35. Tanaka, K., Tanoshita, R., Konishi, M., Oshimura, M., Maeda, Y., Mori, T., and Miyaki, M. (1993). Suppression of tumourigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region. Oncogene 8, 2253-2258.
36. Thoraval, D., Asakawa, J., Kodaira, M., Chang, C., Radany, E., Kuick, R., Lamb, B., Richardson, B., Neel, J.V., Glover, T., and Hanash, S.M. (1996). A methylated human 9-kb repetitive sequence on acrocentric chromosomes is homologous to a subtelomeric repeat in chimpanzee. Proc. Natl. Acad. Sci. USA 93, 4442-4447.
37. Wang, Y.K., Liao, P.-C., Allison, J., Gage, D.A., Andrews, P.C., Lubman, D.M., Hanash, S.M., and Strahler, J.R. (1993). Phorbol 12-myristate 13-acetate-induced phosphorylation of Op18 in Jurkat T cells. The J. Biol. Chem. 268, 14269-14277.
38. Zhu, X.X., Kozarsky, K., Strahler, J.R., Eckerskorn, C., Lottspeich, F., Melhem, R., Lowe, J., Fox, D.A., Hanash, S.M., and Atweh, G.F. (1989). Molecular cloning of a novel human leukemia associated gene: evidence of conservation in animal species. J. Biol. Chem. 264, 14556-14560.