Cytokine profiles in a rat model of otitis media with effusion caused by eustachian tube obstruction with and without Streptococcus pneumoniae infection

Laryngoscope

Volumn 112, Issue 9, 2002, Pages 1657-1662

  Hebda, Patricia A ^a   Piltcher, Otavio B ^a   Swarts, J Douglas ^a   Alper, Cuneyt M ^a   Zeevi, Adriana ^a   Doyle, William J ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Cytokines; Eustachian tube obstruction; Otitis media; Rat model

Indexed keywords

AMPICILLIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY TUBE DYSFUNCTION; AUDITORY TUBE OBSTRUCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RAT; RNA ANALYSIS; SECRETORY OTITIS MEDIA; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE;

AMPICILLIN; ANALYSIS OF VARIANCE; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EUSTACHIAN TUBE; MALE; OTITIS MEDIA WITH EFFUSION; PENICILLINS; RATS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; UP-REGULATION;

EID: 0036725590     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200209000-00024     Document Type: Article

References (34)

1. Epidemiology of otitis media during the first seven years of life in children in greater Boston: A prospective, cohort study
2. Middle ear effusions definitions and terminology
3. Modified Report of the Ad Hoc Committee on definition and classification of otitis media
4. A controlled trial comparing three treatments for chronic otitis media with effusion
5. The role of adjuvant adenoidectomy and tonsillectomy in the outcome of the insertion of tympanostomy tubes
6. Meta-analysis of tympanostomy tube sequelae
7. Anatomy and physiology of eustachian tube and middle ear related to otitis media
8. Prostaglandins, leukotriens, and other arachidonic acid metabolites in the pathogenesis of otitis media
9. Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla
10. Systemic steroids for otitis media with effusion in children
11. Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ('secretory' otitis media) in children: Results of a double-blind, randomized trial
12. Presence of interferon during otitis media
13. Tumor necrosis factor in middle ear effusions
14. Characterization of cytokines present in middle ear effusions
15. The levels of IL-1B in human middle ear effusions
16. Cytokines in experimental otitis media with effusion
17. Expression of immunoregulatory cytokines during acute and chronic middle ear immune response
18. Cytokines, immunoglobulins, and bacterial pathogens in middle ear effusions
19. Early-response cytokine expression in adult middle ear effusions
20. Middle ear fluid cytokine and inflammatory cell kinetics in the chinchilla otitis media model
21. Course of IL-1beta, IL-6, IL-8, and TNF-alpha in the middle ear fluid of the guinea pig otitis media model induced by nonviable Haemophilus influenzae
22. Early inflammatory events in a rat model of OM caused by infection with S. pneumoniae
23. Upregulation of messenger RNA for inflammatory cytokines in middle ear mucosa in a rat model of acute otitis media
24. Expression of cytokine genes during pneumococcal and nontypeable Haemophilus influenzae acute otitis media in the rat
25. The interleukines
26. A persistent otitis media with effusion: A new experimental model
27. The transforming growth factor-betas: A new family of immunoregulatory molecules
28. Transforming growth factor b: The good, the bad and the ugly
29. Transforming growth factor β: The dark size of tissue repair
30. Neutrophil-activating peptide/interleukin-8: A novel cytokine that activates neutrophils
31. Human alveolar macrophages gene expression of interleukin-8 by tumor necrosis factor-a, lipopolysacharide, and interleukin-1b
32. Role for macrophage inflammatory protein-2 in lipopolysaccharide-induced lung injury in rats
33. IL-10 Inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes