Proguanylin secretion and the role of negative-feedback inhibition in a villous epithelial cell line

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 283, Issue 3 46-3, 2002, Pages

  Rudolph, Jeffrey A ^a   Hawkins, Jennifer A ^a   Cohen, Mitchell B ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Chloride secretion; Guanylin; Transwell inserts

Indexed keywords

GUANYLIN; PROGUANYLIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; CELL DIFFERENTIATION; CELL SPECIFICITY; CELL STRAIN CACO 2; ENZYME ACTIVATION; EPITHELIUM CELL; IMMUNOREACTIVITY; INTESTINE VILLUS; MOLECULAR CLONING; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0036721278     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00433.2001     Document Type: Article

References (39)

1. Renal effects of uroguanylin and guanylin in vivo
2. Enterochromaffin cells of the digestive system: Cellular source of guanylin, a guanylate cyclase-activating peptide
3. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
4. Guanylin mRNA expression in human intestine and colorectal adenocarcinoma
5. The immature rat small intestine exhibits an increased sensitivity and response to Escherichia coli heat-stable enterotoxin
6. Immunohistochemical localization of guanylin in the rat small intestine and colon
7. Guanylin: An endogenous activator of intestinal guanylate cyclase
8. Sucrase-isomaltase expression and enterocytic ultrastructure of human colorectal tumors
9. Expression of guanylin in "pars tuberalis-specific cells" and gonadotrophs of rat adenohypophysis
10. The effect of staurosporine, a protein kinase inhibitor, on asialoglycoprotein receptor endocytosis
11. Heat-stable enterotoxin of Escherichia coli: In vitro effects on guanylate cyclase activity, cyclic GMP concentration and ion transport in small intestine
12. Binding of Escherichia coli heat-stable enterotoxin to receptors on rat intestinal cells
13. Small and large intestinal guanylate cyclase activity in children: Effect of age and stimulation by Escherichia coli heat-stable enterotoxin
14. Prouroguanylin and proguanylin: Purification from colon, structure, and modulation of bioactivity by proteases
15. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
16. Analysis of the human guanylin gene and the processing and cellular localization of the peptide
17. Hepatocyte nuclear factor-1α regulates transcription of the guanylin gene
18. Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli
19. + exchanger (NHE3) in three clones of Caco-2 cells
20. The circulating bioactive form of human guanylin is a high molecular weight peptide (10.3 kDa)
21. Upregulation of the Escherichia coli heat-stable enterotoxin receptor in the regenerating rat liver
22. Novel sites for expression of an Escherichia coli heat-stable enterotoxin receptor in the developing rat
23. Peptide-regulated guanylate cyclase pathways in rat colon: In situ localization of GCA, GCC, and guanylin mRNA
24. Guanylin, an endogenous ligand for C-type guanylate cyclase, is produced by goblet cells in the rat intestine
25. Structure and activity of OK-GC: A kidney receptor guanylate cyclase activated by guanylin peptides
26. Comparison of receptors for Escherichia coli heat-stable enterotoxin: Novel receptor present in IEC-6 cells
27. Developmental and tissue-specific expression of rat T-kininogen
28. Regulated, side-directed secretion of proguanylin from isolated rat colonic mucosa
29. Release of guanylin immunoreactivity from the isolated vascularly perfused rat colon
30. Heat-shock protein 72 protects against oxidant-induced injury of barrier function of human colonic epithelial Caco2/bbe cells
31. Identification of 10-kDa proguanylin as a major guanylin molecule in human intestine and plasma and its increase in renal insufficiency
32. Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP
33. Constitutive and regulated secretion of secretory leukocyte proteinase inhibitor by human intestinal epithelial cells
34. Expression of guanylin is downregulated in mouse and human intestinal adenomas
35. Activation of the cystic fibrosis transmembrane conductance regulator by cGMP in the human colonic cancer cell line, Caco-2
36. Cyclic GMP synthesis and function
37. Uroguanylin and guanylin: Distinct but overlapping patterns of messenger RNA expression in mouse intestine
38. Human guanylin: cDNA isolation, structure and activity
39. Expression of enzymatically, active sucrase-isomaltase is a ubiquitous property of colon adenocarcinomas