Base substitutions, targeted single-base deletions, and chromosomal translocations induced by bleomycin in plateau-phase mammary epithelial cells

Radiation Research

Volumn 158, Issue 3, 2002, Pages 327-338

  Yu, Yin ^a   Inamdar, Kedar V ^a   Turner, Kristi ^a   Jackson Cook, Colleen K ^a   Povirk, Lawrence F ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ARTICLE; BREAST EPITHELIUM; CELL IMMORTALIZATION; CELL PROLIFERATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; GENE DELETION; GENE LOCUS; GENE MUTATION; HUMAN; HUMAN CELL; KARYOTYPE; MUTAGENESIS; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL;

CRICETINAE; CRICETULUS GRISEUS;

EID: 0036720748     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2002)158[0327:BSTSBD]2.0.CO;2     Document Type: Article

References (52)

1. Ionizing radiation and genetic risks. III. Nature of spontaneous and radiation-induced mutations in mammalian in vitro systems and mechanisms of induction of mutations by radiation
2. Repair of ionizing radiation damage in mammalian cells. Alternative pathways and their fidelity
3. Cellular, molecular, and carcinogenic effects of radiation
4. Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts
5. DNA sequence analysis of gamma radiation-induced deletions and insertions at the APRT locus of hamster cells
6. Single base-pair deletions induced by bleomycin at potential double-strand cleavage sites in the aprt gene of stationary phase Chinese hamster ovary D422 cells
7. Targeted base substitutions and small deletions induced by neocarzinostatin at the APRT locus in plateauphase CHO cells
8. DNA-damage and mutagenesis by radiomimetic DNA-cleaving agents: Bleomycin, neocarzinostatin and other enediynes
9. Highly conservative reciprocal translocations formed by apparent joining of exchanged DNA double-strand break ends
10. In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes
11. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene
12. CIPI/Wafl expression in human breast epithelial cells
13. Growth arrest and non-apoptotic cell death associated with the suppression of c-myc expression in MCF-7 breast tumor cells following acute exposure to doxorubicin
14. Quantification of chemical mutagenesis in diploid human fibroblasts: Induction of azaguanine-resistant mutants by N-methyl-N′-nitro-N-nitrosoguanidine
15. Amplification and direct nucleotide sequencing of cDNA from the lysate of low numbers of diploid human cells
16. Multiplex DNA deletion detection and exon sequencing of the hypoxanthine phosphoribosyltransferase gene in Lesch-Nyhan families
17. The effects of hypoxia and cysteamine on X-ray mutagenesis in human cells. II. hprt mRNA expression and cDNA sequence analysis of induced mutants
18. Bleomycin-induced DNA lesions at mutational hot spots: Implications for the mechanism of double-strand cleavage
19. Structure of bleomycin-induced DNA double-strand breaks: Predominance of blunt ends and single-base 5′ extensions
20. Sequence-specific double-strand cleavage of DNA by Fe-bleomycin. 1. The detection of sequence-specific double-strand breaks using hairpin oligonucleotides
21. Computer program for the analysis of mutational spectra: Application to p53 mutations
22. Cytogenetic characterization of the human prostate cancer cell line P69SV40T and its novel tumorigenic sublines M2128 and M15
23. The application of spectral karyotyping (SKY) and fluorescent in situ hybridization (FISH) technology to determine the chromosomal content(s) of micronuclei
24. Cell-cycle analysis using a monoclonal antibody to BrdUrd
25. Bleomycin-induced mutagenesis in repackaged lambda phage: Base substitution hotspots at the sequence C-G-C-C
26. Bleomycin-dependent damage to the bases in DNA is a minor side reaction
27. Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin
28. Interaction of bleomycin with DNA
29. Comparison of the sequences at specific sites on DNA cleaved by the antitumor antibiotics talisomycin and bleomycin
30. Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin
31. Cloning and characterization of Chinese hamster p53 cDNA
32. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins
33. 1 arrest
34. Spectra of spontaneous and X-ray-induced mutations at the hprt locus in related human lymphoblast cell lines that express wild-type or mutant p53
35. Spectra of X-ray-induced and spontaneous intragenic HPRT mutations in closely related human cells differentially expressing the p53 tumor suppressor gene
36. p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells
37. 1-phase checkpoint
38. Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice
39. Radiation-induced damage, repair and exchange formation in different chromosomes of human fibroblasts determined by fluorescence in situ hybridization
40. Underestimation of the small residual damage when measuring DNA double-strand breaks (DSB): Is the repair of radiation-induced DSB complete?
41. Rapid and slow DNA rejoining in nondividing human diploid fibroblasts treated with bleomycin and ionizing radiation
42. Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: Association with delayed reproductive death phenotype
43. Persistence of radiation-induced translocations in human peripheral blood determined by chromosome painting
44. 0 human lymphocytes and their fate through mitotic divisions in culture
45. The persistence of aberrations in mice induced by gamma radiation as measured by chromosome painting
46. Noninvolvement of the X chromosome in radiation-induced chromosome translocations in the human lymphoblastoid cell line TK6
47. Noninvolvement of the human X chromosome in X-ray induced exchanges
48. 1 or S phase
49. Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments. II. Experimental detection
50. Mutational spectra at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in T-lymphocytes of nonsmoking and smoking lung cancer patients
51. Nature of mutation in the human hprt gene following in vivo exposure to ionizing radiation of cesium-137