Thrombin-induced expression of RANTES mRNA through protease activated receptor-1 in human synovial fibroblasts

Annals of the Rheumatic Diseases

Volumn 61, Issue 9, 2002, Pages 834-837

  Hirano, F ^a   Kobayashi, A ^a   Hirano, Y ^a   Nomura, Y ^a   Fukawa, E ^a   Makino, I ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; RANTES; THROMBIN; THROMBIN RECEPTOR;

ARTICLE; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; FIBROBLAST; FIBROBLAST CULTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATORY CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE; SYNOVIUM; TATA BOX;

APOPTOSIS REGULATORY PROTEINS; ARTHRITIS, RHEUMATOID; BETA-GALACTOSIDASE; CAENORHABDITIS ELEGANS PROTEINS; CARRIER PROTEINS; CELLS, CULTURED; FIBROBLASTS; GENE EXPRESSION; HELA CELLS; HELMINTH PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RANTES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYNOVIAL MEMBRANE; THROMBIN; TRANSFECTION;

EID: 0036720715     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.61.9.834     Document Type: Article

References (15)

1. RANTES role in rheumatoid arthritis
2. In vitro migration of mononuclear cells towards synovial fluid and plasma from rheumatoid arthritis patients correlates to RANTES synovial fluid levels and to clinical pain parameters
3. Relationship belween serum RANTES levels and radiological progression in rheumatoid arthritis patients treated with methotrexate
4. Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model
5. Thrombin receptor-mediated synovial proliferation in patients with rheumatoid arthritis
6. Thrombin stimulates cell proliferation in human fibroblast-like synoviocytes in nuclear factor-κB activation and protein kinase C mediated pathway
7. Amelioration of collagen-induced arthritis by thrombin inhibition
8. Thrombin receptor expression in rheumatoid and osteoarthritic synovial tissue
9. Alternative splicing variants of IκBβ establish differential NF-κB signal responsiveness in human cells
10. Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR 1
11. PAR3 is a cofactor for PAR4 activation by thrombin
12. The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a Par gene cluster and characterization in vascular endothelial cells and platelets
13. Differential transcriptional regulation of the human thrombin receptor gene by the Sp family of transcription factors in human endothelial cells
14. Thrombin induces proteinase-activated receptor-1 gene expression in endothelial cells via activotion of Gi-linked Ras/mitogen-activated protein kinase pathway
15. Tumor necrosis factor decreases thrombin receptor expression in endothelial cells