Cyclosporin A blocks the expression of lymphotoxin α, but not lymphotoxin β, in human peripheral blood mononuclear cells

Blood

Volumn 100, Issue 5, 2002, Pages 1721-1727

  Kuprash, Dmitry V ^a,b,c,d   Boitchenko, Veronica E ^a,b,c,d   Yarovinsky, Felix O ^a,b,c,d   Rice, Nancy R ^a,b,c,d   Nordheim, Alfred ^a,b,c,d   Rühlmann, Andreas ^a,b,c,d   Nedospasov, Sergei A ^a,b,c,d,e  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c SAIC FREDERICK INC   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD40 LIGAND; CYCLOSPORIN A; FAS ANTIGEN; IONOMYCIN; LYMPHOTOXIN; LYMPHOTOXIN BETA; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

BASE SEQUENCE; CELLS, CULTURED; CYCLOSPORINE; DOWN-REGULATION; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTES, MONONUCLEAR; LYMPHOTOXIN-ALPHA; LYMPHOTOXIN-BETA; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA;

EID: 0036720395     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
2. Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily
3. TNF-related ligands and their receptors
4. Development and maturation of secondary lymphoid tissues
5. The TNF and TNF receptor superfamilies: Integrating mammalian biology
6. Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity
7. Lymphotoxin is expressed as a heteromeric complex with a distinct 33-kDa glycoprotein on the surface of an activated human T cell hybridoma
8. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface
9. Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors
10. Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells
11. Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice
12. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice
13. Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice
14. Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs
15. Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization
16. Lymph node genesis is induced by signaling through the lymphotoxin beta receptor
17. Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice
18. Turning off follicular dendritic cells
19. B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion
20. Susceptibility locus for IgA deficiency and common variable immunodeficiency in the HLA-DR3, -B8, -A1 haplotypes
21. Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction
22. Genomic sequencing
23. Cyclosporin A blocks PMA and ionomycin activated lymphotoxin expression in a human T-cell line
24. Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome
25. Expression of NFAT-family proteins in normal human T cells
26. In vivo control of NF-kappa B activation by I kappa B alpha
27. Conserved kappa B element located downstream of the tumor necrosis factor alpha gene: Distinct NF-kappa B binding pattern and enhancer activity in LPS activated murine macrophages
28. Differential regulation of lymphotoxin (LT), lymphotoxin-beta (LT-beta), and TNF-alpha in murine T cell clones activated through the TCR
29. MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data
30. Manipulating immune responses with immunosuppressive agents that target NFAT
31. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation
32. Inducible nuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner
33. Tumor necrosis factor beta (TNF-beta) induces binding of the NF-kappa B transcription factor to a high-affinity kappa B element in the TNF-beta promoter
34. Lymphotoxin activation by human T-cell leukemia virus type I-infected cell lines: Role for NF-kappa B
35. Human T-lymphotropic virus type I tax regulates the expression of the human lymphotoxin gene
36. The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-kappa B in human T-cell lines
37. 2+, calcineurin, and NF-AT
38. Transcription factors of the NFAT family: Regulation and function
39. Gene regulation mediated by calcium signals in T lymphocytes
40. T cell receptor-induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A
41. Inhibition of cytokine production by cyclosporin A and transforming growth factor beta
42. Comparison of patterns of expression of tumour necrosis factor, lymphotoxin and interleukin-6 mRNA
43. Lymphokine production in cyclosporine-treated renal transplant recipients
44. Inhibition of cytokine production by cyclosporine A and G
45. A poly(dAdT) upstream activating sequence binds high-mobility group I protein and contributes to lymphotoxin (tumor necrosis factor-beta) gene regulation
46. Ruddie molecular regulation of tumor necrosis factor-alpha and lymphotoxin production In T cells. Inhibition by prostaglandin E2
47. T cells which do not express membrane tumor necrosis factor-alpha activate macrophage effector function by cell contact- dependent signaling of macrophage tumor necrosis factor-alpha production
48. Functional analysis of the lymphotoxin-beta promoter. Sequence requirements for PMA activation
49. CD40 ligation and IL-4 use different mechanisms of transcriptional activation of the human lymphotoxin alpha promoter in B cells
50. The architecture of the interleukin-2 promoter: A reflection of T lymphocyte activation
51. Transcriptional and post-transcriptional mechanisms involved in the differential expression of LPS-induced IL-1 and TNF mRNA
52. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
53. Cloning and expression analysis of the murine lymphotoxin beta gene
54. Thymic and lymphoid changes and serum immunoglobulin abnormalities in mice receiving cyclosporine