Variation within serovars of Neisseria gonorrhoeae detected by structural analysis of outer-membrane protein PIB and by pulsed-field gel electrophoresis

Microbiology

Volumn 143, Issue 4, 1997, Pages 1415-1422

  Cooke, Susan J ^a   De La Paz, Helen ^b   La Poh, Chit ^b   Ison, Catherine A ^c   Heckels, John E ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Gonococcal PIB; Neisseria gonorrhoeae; Outer membrane protein PIB; Serovars

Indexed keywords

ANTIGEN; BACTERIAL ANTIGEN; EPITOPE; OUTER MEMBRANE PROTEIN; VACCINE;

AMINO ACID SEQUENCE; ANTIGEN SPECIFICITY; ARTICLE; BACTERIUM ISOLATION; CONTROLLED STUDY; GENE SEQUENCE; GENETIC HETEROGENEITY; NEISSERIA GONORRHOEAE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PULSED FIELD GEL ELECTROPHORESIS; SEROTYPING; VACCINATION;

BACTERIA (MICROORGANISMS); NEISSERIA GONORRHOEAE;

EID: 0030978364     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-143-4-1415     Document Type: Article

References (25)

1. Anderson, R. M., Gupta, S. & Ng, W. (1990). The significance of sexual partner contact networks for the transmission dynamics of HIV. J Acquired Immune Defic Syndr 2, 417-419.
2. Brooks, J. L., Fallon, R. J. & Heckels, J. E. (1995). Sequence variation in class 1 outer membrane protein in Neisseria meningitidis isolated from patients with meningococcal infection and close household contacts. FEMS Microbiol Lett 128, 145-150.
3. Butt, N. J., Lambden, P. R. & Heckels, J. E. (1990a). The nucleotide sequence of por gene encoding expression of outer membrane protein PIB in Neisseria gonorrhoeas strain P9. Nucleic Acids Res 14, 4258.
4. Butt, N. J., Virji, M., Vayreda, F., Lambden, P. R. & Heckels, J. E. (1990b). Gonococcal outer-membrane protein PIB: comparative sequence analysis and localization of epitopes which are recognized by type-specific and cross-reacting monoclonal antibodies. J Gen Microbiol 136, 2165-2172.
5. Carbonetti, N. H. & Sparling, P. F. (1987). Molecular cloning and characterization of the structural gene for protein I, the major outer membrane protein of Neisseria gonorrhoeae. Proc Natl Acad Sci USA 84, 9084-9088.
6. Carbonetti, N. H., Simnad, V. I., Seifert, H. S., So, M. & Sparling, P. F. (1988). Genetics of protein I of Neisseria gonorrhoeae: construction of hybrid porins. Proc Natl Acad Sci USA 85, 6841-6845.
7. Douglas, J. T., Lee, M. D. & Nikaido, H. (1981). Protein I of Neisseria gonorrhoeae outer membrane is a porin. FEMS Microbiol Lett 12, 305-309.
8. Elkins, C., Carbonetti, N. H., Varela, V. A., Stirewalt, D., Klapper, D. G. & Sparling, P. F. (1992). Antibodies to N-terminal peptides of gonococcal porin are bactericidal when gonococcal lipopolysaccharide is not sialylated. Mol Microbiol 6, 2617-2628.
9. Gill, M. J. (1991). Serotyping Neisseria gonorrhoeae: a report of the fourth international workshop. Genitourin Med 67, 53-57.
10. Gotschlich, E. C., Seiff, M. E., Blake, M. S. & Koomey, M. (1987). Porin protein of Neisseria gonorrhoeae: cloning and gene structure. Proc Natl Acad Sci USA 84, 8135-8139.
11. Heckels, J. E., Virji, M. & Tinsley, C. R. (1990). Vaccination against gonorrhoeae: the potential protective effect of immunization with a synthetic peptide containing a conserved epitope of gonococcal outer membrane protein IB. Vaccine 8, 225-230.
12. Ison, C. A., Whitaker, L. & Renton, A. (1992). Concordance of auxotype/serovar classes of Neisseria gonorrhoeae between sexual contacts. Epidemiol Infect 109, 265-271.
13. Knapp, J. S., Tam, M. R., Nowinski, R. C., Holmes, K. K. & Sandstrom, E. G. (1984). Serological classification of Neisseria gonorrhoeae with use of monoclonal antibodies to gonococcal outer membrane protein I. J Infect Dis 50, 44-48.
14. Knapp, J. S., Holmes, K. K., Bonin, P. & Hook, E. W. (1987). Epidemiology of gonorrhoea: distribution and temporal changes in auxotype/serovar classes of Neisseria gonorrhoeae. Sex Transm Dis 14, 26-32.
15. McGuinness, B. T., Lambden, P. R. & Heckels, J. E. (1993). Class 1 outer membrane protein of Neisseria meningitidis: epitope analysis of the antigenic diversity between strains, implications for subtype definition and molecular epidemiology. Mol Microbiol 7, 505-514.
16. Maiden, M. C. J., Bygraves, J. A., McCarvil, J. & Feavers, I. M. (1992). Identification of meningococcal serosubtypes by polymerase chain reaction. J Clin Microbiol 30, 2835-2841.
17. Mee, B. J., Thomas, H., Cooke, S. J., Lambden, P. R. & Heckels, J. E. (1993). Structural comparison and epitope analysis of outer-membrane protein PIA from strains of Neisseria gonorrhoeae with differing serovar specificities. J Gen Microbiol 139, 2613-2620.
18. O'Rourke, M., Ison, C. A., Renton, A. M. & Spratt, B. G. (1995). Opa-typing: a high resolution tool for studying the epidemiology of gonorrhoea. Mol Microbiol 17, 865-875.
19. Poh, C. L. & Lau, Q. C. (1993). Subtyping of Neisseria gonorrhoeae auxotype-serovar groups by pulsed-field gel-electrophoresis. J Med Microbiol 38, 366-370.
20. Sandstrom, E. G., Chen, K. C. S. & Buchanan, T. M. (1982). Serology of Neisseria gonorrhoeae: co-agglutination serogroups WI and WII/III correspond to different outer membrane protein molecules. Infect Immun 38, 462-470.
21. Suker, J., Feavers, I. M., Achtman, M., Morelli, G., Wang, J. F. & Maiden, M. C. J. (1994). The porA gene in serogroup A meningococci: evolutionary stability and mechanism of genetic variation. Mol Microbiol 12, 253-265.
22. Van der Ley, P., Heckels, J. E., Virji, M., Hoogerhout, P. & Poolman, J. T. (1991). Topology of outer membrane porins in pathogenic Neisseria spp. Infect Immun 59, 2963-2971.
23. Virji, M., Zak, K. & Heckels, J. E. (1986). Monoclonal antibodies to gonococcal outer membrane protein IB: use in investigation of the potential protective effect of antibodies directed against conserved and type-specific epitopes. J Gen Microbiol 132, 1621-1629.
24. Virji, M., Fletcher, J. N., Zak, K. & Heckels, J. E. (1987). The potential protective effect of monoclonal antibodies to gonococcal outer membrane protein IA. J Gen Microbiol 133, 2639-2646.
25. Zak, K., Diaz, J. L., Jackson, D. & Heckels, J. E. (1984). Antigenic variation during infection with Neisseria gonorrhoeae: detection of antibodies to surface proteins in sera of patients with gonorrhea. J Infect Dis 149, 166-173.