The impact of a transgene for ovine growth hormone on the performance of two breeds of sheep

Journal of Animal Science

Volumn 80, Issue 9, 2002, Pages 2325-2333

  Adams, N R ^a   Briegel, J R ^a   Ward, K A ^a  

^a CSIRO   (Australia)

Author keywords

Genetic Engineering; Obesity; Sheep; Somatotropin; Wool Production

Indexed keywords

ANIMALIA; OVIS; OVIS ARIES;

GROWTH HORMONE;

ANIMAL; ANIMAL DISEASE; ANIMAL PARASITOSIS; ARTICLE; BLOOD; FECES; FEMALE; GENETIC PREDISPOSITION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALE; PARASITE IDENTIFICATION; PARASITOLOGY; PHYSIOLOGY; PREGNANCY; REPRODUCTION; SECRETION; SHEEP; SHEEP DISEASE; TRANSGENE; TRANSGENIC ANIMAL; WOOL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; FECES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GROWTH HORMONE; MALE; PARASITE EGG COUNT; PARASITIC DISEASES, ANIMAL; PREGNANCY; REPRODUCTION; SHEEP; SHEEP DISEASES; TRANSGENES; WOOL;

EID: 0036719011     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.1093/ansci/80.9.2325     Document Type: Article

References (35)

1. Adams, N. R., J. R. Briegel, R. D. G. Rigby, M. R. Sanders, and R. M. Hoskinson. 1996. Responses of sheep to annual cycles in nutrition 1. Role of endogenous growth hormone during under-nutrition. Anim. Sci. 62:279-286.
2. Adams, N. R., S. Liu, and D. G. Masters. 2000. Regulation of protein synthesis for wool growth. In: P. B. Cronje (ed.) Ruminant Physiology. Digestion, Metabolism, Growth and Reproduction, pp 255-272. CABI International, Wallingford, Oxon UK.
3. Bartke, A., M. Cecim, K. Tang, R. W. Steger, V. Chandrashekar, and D. Turyn. 1994. Neuroendocrine and reproductive consequences of overexpression of growth hormone in transgenic mice. Proc. Soc. Exp. Biol. Med. 206:345-359.
4. Bell, A. M., L. R. Piper, B. W. Brown, K. A. Ward, and B. C. Hine. 2001. Effect of ovine growth hormone transgenesis on performance of Merino sheep at pasture. 1. Parasite resistance, feed conversion efficiency and growth hormone levels. In: Proc. Assoc. Adv. Anim. Breed. Genet. Queenstown, New Zealand. 14:261-264.
5. Cecim, M., P. K. Ghosh, A. I. Esquifino, T. Began, T. E. Wagner, J. S. Yun, and A. Bartke. 1991. Elevated corticosterone levels in transgenic mice expressing human or bovine growth hormone. Neuroendocrinology 53:313-316.
6. Collier, R. J., J. C. Byatt, S. C. Denham, P. J. Eppard, A. C. Fabellar, R. L. Hintz, M. F. McGrath, C. L. McLaughlin, J. K. Shearer, J. J. Veenhuizen, and J. L. Vicini. 2001. Effects of sustained release bovine somatotropin (Sometribove) on animal health in commercial dairy herds. J. Dairy Sci. 84:1098-1108.
7. Deplewski, D. and R. L. Rosenfield. 1999. Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinology 140:4089-4094.
8. Devlin, R. H., C. A. Biagi, T. Y. Yesaki, D. E. Smailus, and J. C. Byatt. 2001. Growth of domesticated transgenic fish. Nature (Lond.) 409:781-782.
9. Dunshea, F. R., Y. R. Biosclair, D. E. Bauman, and A. W. Bell. 1995. Effects of bovine somatotropin and insulin on whole-body and hindlimb glucose metabolism in growing steers. J. Anim. Sci. 73:2263-2271.
10. Freer, M., A. D. Moore, and J. R. Donnelly. 1997. Decision support systems for Australian grazing enterprises. II The animal biology model for feed intake, production and reproduction and the Grazfeed DSS. Agric. Sys. 53:77-126.
11. Garrick, D., S. Fiering, D. I. K. Martin, and E. Whitelaw. 1998. Repeat-induced gene silencing in mammals. Nat. Genet. 18:56.
12. Giustina, A., A. Barkan, F. F. Casanueva, F. Cavagnini, L. Frohman, K. Ho, J. D. Veldhuis, J. Wass, K. von Werder, and S. Melmed. 2000. Criteria for cure of acromegaly: a consensus statement. J. Clin. Endocrinol. Metab. 85:526-529.
13. Gootwine, E., J. M. Suttie, J. C. McEwan, B. A. Veenvliet, R. P. Littlejohn, P. F. Fennessy, and G. W. Montgonery. 1998. The physiological effects of natural variation in growth hormone gene copy number in ram lambs. Domest. Anim. Endocrinol. 14:381-390.
14. Houdijk, J. G. M., I. Kyriazakis, F. Jackson, and R. L. Coop. 2001. The relationship between protein nutrition, reproductive effort and breakdown in immunity to Teladorsagia circumcincta in periparturient ewes. Anim. Sci. 72:595-606.
15. Johnsson, I. D., I. C. Hart, and B. W. Butler-Hogg. 1985. The effects of exogenous bovine growth hormone and bromocryptine on growth, body development, fleece weight and plasma concentrations of growth hormone, insulin and prolactin in female lambs. Anim. Prod. 41:207-217.
16. Kaps, M., A. S. A. M. T. Moura, T. J. Safranski, and W. R. Lamberson. 1999. Components of growth in mice hemizygous for a MT/bGH transgene. J. Anim. Sci. 77:1148-1154.
17. Lobley, G. E. 1998. Nutritional and hormonal control of muscle and peripheral tissue metabolism in farm species. Livest. Prod. Sci. 56:91-114.
18. MacRae, J. C., L. A. Bruce, F. D. D. Hovell, I. C. Hart, J. Inkster, A. Walker, and T. Atkinson. 1991. Influence of protein nutrition on the response of growing lambs to exogenous bovine growth hormone. J. Endocrinol. 130:53-61.
19. Marx, J. 2000. Interfering with gene expression. Science (Wash, DC) 288:1370-1373.
20. Murray, J. D., C. D. Nancarrow, J. T. Marshall, I. G. Hazelton, and K. A. Ward. 1989. Production of transgenic Merino sheep by microinjection of ovine metallothionine-ovine growth hormone fusion genes. Reprod. Fertil. Dev. 1:147-155.
21. Nash, J. E., H. J. G. Rocha, V. Buchan, G. A. Calder, E. Milne, J. F. Quirke, and G. E. Lobley. 1994. The effect of acute and chronic administration of the β-agonist, cimaterol, on protein synthesis in ovine skin and muscle. Br. J. Nutr. 71:501-513.
22. O'Sullivan, A. J., J. J. Kelly, D. M. Hoffman, J. Freund, and K. K. Y. Ho. 1994. Body composition and energy expenditure in acromegaly. J. Clin. Endocrinol. Metab. 78:381-386.
23. Parker, W. J., A. E. Dooley, and D. J. Garrick. 1998. Sheep breeding: an enterprise budgeting decision support model for on-farm planning. Proc. N. Z. Soc. Anim. Prod. 58:165-169.
24. Piper, L. R., A. M. Bell, K. A. Ward, and B. W. Brown. 2001. Effect of ovine growth hormone transgenesis on performance of Merino sheep at pasture. 1. Growth and wool traits to 12 mo of age. In: Proc. Assoc. Advanc. Anim. Breed. Genet. Queenstown, New Zealand. 14:257-260.
25. Reklewska, B. 1974. A note on the effect of bovine somatotrophic hormone on wool production in growing lambs. Anim. Prod. 19:253-255.
26. Rexroad, C. E., R. R. Behringer, D. J. Bolt, K. F. Miller, R. D. Palmiter, and R. L. Brinster. 1988. Insertion and expression of a growth hormone fusion gene in sheep. J. Anim. Sci. 66(Suppl. 1):267 (Abstr.).
27. Russel, A. J. F., J. M. Doney, and R. G. Gunn. 1969. Subjective assessment of body fat in live sheep. J. Agric. Sci. 72:451-454.
28. Siewerdt, F., E. J. Eisen, J. D. Murray, and I. J. Parker. 2000. Response to 13 generations of selection for increased 8-week body weight in lines of mice carrying a sheep growth hormone-based transgene. J. Anim. Sci. 78:832-845.
29. Sinnett-Smith, P. A., J. A. Woolliams, P. D. Warriss, and M. Enser. 1989. Effects of recombinant DNA-derived bovine somatotropin on growth, carcass characteristics and meat quality in lambs from three breeds. Anim. Prod. 49:281-289.
30. Span, J. P. T., G. F. F. M. Pieters, C. G. J. Sweep, A. R. M. M. Hermus, and A. G. H. Smals. 2000. Gender differences in insulin-like growth factor I response to growth hormone (GH) treatment in GH-deficient adults: role of sex hormone replacement. J. Clin. Endocrinol. Metab. 85:1121-1125.
31. Veldhuis, J. D., A. Y. Liem, S. South, A. Weltman, J. Weltman, D. A. Clemmons, R. Abbott, T. Mulligan, M. L. Johnson, S. Pincus, M. Straume, and A. Iranmanesh. 1995. Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. Endocrinology 80:3209-3222.
32. Wanke, R., S. Milz, N. Rieger, L. Ogiolda, I. Renner-Muller, G. Brem, W. Hermanns, and E. Wolf. 1999. Overgrowth of skin in growth hormone transgenic mice depends on the presence of male gonads. J. Investig. Dermatol. 113:967-971.
33. Ward, K. A., and B. W. Brown. 1998. The production of transgenic domestic livestock: successes, failures and the need for nuclear transfer. Reprod. Fertil. Dev. 10:659-665.
34. Wheeler, J. L., D. A. Hedges, and C. Mulcahy. 1977. The use of dyebanding form measuring wool production and fleece tip wear in rugged and unrugged sheep. Aust. J. Agric. Res. 28:721-735.
35. Wynn, P. C., A. L. C. Wallace, A. C. Kirby, and E. F. Annison. 1988. Effects of growth hormone administration on wool growth in merino sheep. Aust. J. Biol. Sci. 41:177-187.