Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit α4β2 neuronal nicotinic acetylcholine receptors

Anesthesia and Analgesia

Volumn 95, Issue 3, 2002, Pages 573-577

  Raines, Douglas E ^a   Claycomb, Robert J ^a   Forman, Stuart A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DICHLOROHEXAFLUOROCYCLOBUTANE; 2,3 DICHLOROOCTAFLUOROBUTANE; BUTANE; CYCLOPROPANE; NICOTINIC RECEPTOR;

AMNESIA; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG MECHANISM; DRUG POTENCY; ELECTROPHYSIOLOGY; GABAERGIC SYSTEM; HYDROPHOBICITY; IMMOBILIZATION; INHIBITION KINETICS; LEARNING; MEMORY; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0036713991     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/00000539-200209000-00015     Document Type: Article

References (18)

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3. Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis
4. Potentiation of gammaaminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia
5. Nonanesthetics can suppress learning
6. Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms
7. Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels
8. Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats
9. Nicotinic receptor function: New perspectives from knockout mice
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11. A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment
12. Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics
13. Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffected
14. Nonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models
15. Human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes predict efficacy of halogenated compounds that disobey the Meyer-Overton rule
16. Inhibitory effects of isoflurane and nonimmobilizing halogenated compounds on neuronal nicotinic receptors
17. Anesthetic potencies of η-alkanols: Results of additivity and solubility studies suggest a mechanism of action similar to that for conventional inhaled anesthetics
18. Table of physical and pharmacological properties of anesthetics