Local release of human neutrophil lipocalin (HNL), IL-8, and TNF-α is decreased as response to topical prednisolone treatment in distal ulcerative colitis and proctitis

Digestive Diseases and Sciences

Volumn 47, Issue 9, 2002, Pages 2064-2069

  Sangfelt, Per ^a   Carlson, Marie ^a   Thörn, Magnus ^a   Xu, Shengyuan ^a   Lööf, Lars ^a   Raab, Yngve ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Human neutrophil lipocalin; Interleukin 8; Treatment; Tumor necrosis factor ; Ulcerative colitis

Indexed keywords

ENEMA; INTERLEUKIN 8; LIPOCALIN; PREDKLYSMA; PREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; DEGRANULATION; FEMALE; GRANULOCYTE; HUMAN; IMMUNOASSAY; MALE; PRIORITY JOURNAL; PROCTITIS; TREATMENT OUTCOME; ULCERATIVE COLITIS;

ACUTE-PHASE PROTEINS; ANTI-INFLAMMATORY AGENTS; CARRIER PROTEINS; COLITIS, ULCERATIVE; ENEMA; HUMANS; INTERLEUKIN-8; NEUTROPHILS; ONCOGENE PROTEINS; PREDNISOLONE; PROCTITIS; PROTO-ONCOGENE PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036713524     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1019681030784     Document Type: Article

References (26)

1. Histopathology in ulcerative colitis
2. Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes
3. Release of inflammatory mediators from stimulated neutrophils
4. Purification and characterization of a human neutrophil lipocalin (HNL) from the secondary granules of human neutrophils
5. Human neutrophil lipocalin (HNL) is a specific granule constituent of the neutrophil granulocyte. Studies in bronchial and lung parenchymal tissue and peripheral blood cells
6. Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans
7. Characterization of two ELISAs for NGAL, a newly described lipocalin in human neutrophils
8. A novel neutrophil-activating factor produced by human mononuclear phagocytes
9. Neutrophil-activating peptide 1/interleukin 8, a novel cytokine that activates neutrophils
10. Monokine-induced neutrophil chemotactic factor gene expression in human fibroblasts
11. Neutrophil and eosinophil granule proteins as markers of response to local prednisolone treatment in distal ulcerative colitis and proctitis
12. A comparison between clinical state, macroscopic and microscopic apperances of rectal mucosa, and cytologic picture of mucosal exudate in ulcerative colitis
13. A technique for segmental rectal and colonic perfusion in humans
14. Regional rectal perfusion: A new in vivo approach to study rectal drug absorption in man
15. The development of an assay for human neutrophil lipocalin (HNL) to be used as a specific marker of neutrophil activity in vivo and in vitro
16. Chemiluminescence assay of mucosal reactive oxygen metabolites in inflammatory bowel disease
17. Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin- 8 in ulcerative colitis
18. Serum myeloperoxidase and lactoferrin in neutropenia
19. Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-alpha in ulcerative colitis
20. Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory diseases
21. Correlations between interleukin-8, and myeloperoxidase or luminol-dependent chemiluminescence in inflamed mucosa of ulcerative colitis
22. Increased interleukin-8 (IL-8) in rectal dialysate from patients with ulcerative colitis: Evidence for a biological role for IL-8 in inflammation of the colon
23. Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis
24. Intraluminal colonic release of immunoreactive tumour necrosis factor in chronic ulcerative colitis
25. Network of inflammatory cytokines and correlation with disease activity in ulcerative colitis
26. Treatment of ulcerative colitis with an engineered human anti-TNFalpha antibody CDP571