Individually addressable parallel peptide synthesis on microchips

Nature Biotechnology

Volumn 20, Issue 9, 2002, Pages 922-926

  Pellois, Jean Philippe ^a   Zhou, Xiaochuan ^b   Srivannavit, Onnop ^c   Zhou, Tiecheng ^b   Gulari, Erdogan ^c   Gao, Xiaolian ^a  

^a University of Houston   (United States)

^b Xeotron Corporation   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBODIES; BIOSYNTHESIS; DRUG PRODUCTS; PHOTOLITHOGRAPHY;

EPITOPE BINDINGS;

BIOMEDICAL ENGINEERING;

AMINO ACID DERIVATIVE; PEPTIDE; PROTEIN ANTIBODY; PROTEIN P53; PROTEIN P53 ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ARTICLE; BINDING KINETICS; COMPUTER PROGRAM; COMPUTER SYSTEM; DIGITAL COMPUTER; DRUG RESEARCH; EPITOPE MAPPING; MEDICAL RESEARCH; MOLECULAR DYNAMICS; OPTICAL INSTRUMENTATION; PEPTIDE SYNTHESIS; PHOTOACTIVATION; PHOTOGRAPHY; PRIORITY JOURNAL; PROCESS DESIGN; PROTEOMICS; REACTION TIME;

AMINO ACID SEQUENCE; EPITOPES; GENES, P53; HUMANS; LIGHT; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES; PHOTOCHEMISTRY; PROTEIN ENGINEERING; QUALITY CONTROL;

EID: 0036712071     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt723     Document Type: Article

References (37)

1. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide
2. Solid phase synthesis
3. A new type of synthetic peptide library for identifying ligand-binding activity
4. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
5. SPOT-synthesis: An easy technique for the positionally addressable, parallel chemical synthesis on a membrane support
6. Light-directed, spatially addressable parallel chemical synthesis
7. Solid-phase synthesis on planar supports
8. From multiple peptide synthesis to peptide libraries
9. Large-scale functional analysis using peptide or protein arrays
10. Applications of display technologies to protein analysis
11. Chemical synthesis of peptide libraries
12. From combinatorial chemistry to chemical microarray
13. From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling
14. Synthesis and screening of peptide libraries on continuous cellulose membrane supports
15. Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides
16. Spot synthesis: Observations and optimizations
17. An unnatural biopolymer
18. Production by quantitative photolithographic synthesis of individually quality checked DNA microarrays
19. Oligonucleotide synthesis using solution photogenerated acids
20. Combinatorial screening method for synthesis optimization on a digital light-controlled microarray platform
21. Peptide synthesis based on Boc chemistry and solution photogenerated acids
22. A flexible DNA chip synthesis gated by deprotection using solution photogenerated acids
23. Mutant conformation of p53. Precise epitope mapping using a filamentous phage epitope library
24. Characterization of epitopes on human p53 using phage displayed peptide libraries: Insights into antibody-peptide interactions
25. Chemical amplification in high-resolution imaging systems
26. Organic resist materials
27. Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array
28. The efficiency of light-directed synthesis of DNA arrays on glass substrates
29. Characterization of oligodeoxyribonucleotide synthesis on glass plates
30. The Chipping Forecast
31. Random peptide libraries: A source of specific protein binding molecules
32. Searching for peptide ligands with an epitope library
33. Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector
34. Peptides on phage: A vast library of peptides for identifying ligands
35. Wavelength-selective cleavage of photolabile protecting groups