Accumulation of S(+) enantiomer in human beings after general anaesthesia with isoflurane racemate

European Journal of Anaesthesiology

Volumn 19, Issue 9, 2002, Pages 641-646

  Haeberle, H A ^a   Wahl, H G ^a   Jakubetz, H ^a   Krause, H ^a   Schmidt, R ^a   Schurig, V ^a   Dieterich, H J ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Anaesthetics, inhalation, isoflurane; Isomerism, stereoisomerism; Molecular structure

Indexed keywords

ALFENTANIL; ETOMIDATE; FENTANYL; ISOFLURANE; MIDAZOLAM; MIVACURIUM; OPIATE AGONIST; PROPOFOL; REMIFENTANIL; ROCURONIUM; SUFENTANIL; SUXAMETHONIUM; THIOPENTAL;

ANESTHETIC RECOVERY; ARTICLE; BALANCED ANESTHESIA; BLOOD SAMPLING; DRUG ACCUMULATION; DRUG METABOLISM; DRUG STRUCTURE; ENANTIOMER; GAS CHROMATOGRAPHY; GENERAL ANESTHESIA; HUMAN; LUNG DISEASE; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; OBESITY; RACEMIC MIXTURE; STATISTICAL ANALYSIS;

EID: 0036711895     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003643-200209000-00004     Document Type: Article

References (18)

1. Chirality and the mode of action of anaesthetics
2. The pharmacology of isoflurane
3. Esters and stereoisomers
4. Isoflurane anesthesia is stereoselective
5. Minimum alveolar anesthetic concentration values for the enantiomers of isoflurane differ minimally
6. Stereo-selective loss of righting reflex in rats by isoflurane
7. The stereo-specific effects of isoflurane isomers in vivo
8. Inhibition of [3H]isradipine binding to L-type calcium channels by the optical isomers of isoflurane. Lack of stereospecificity
9. Headspace gas chromatography-mass spectrometry analysis of isoflurane enantiomers in blood samples after anesthesia with the racemic mixture
10. 19F nuclear magnetic resonance brain studies of halothane, isoflurane, and desflurane. Rapid elimination and no abundant saturable binding
11. Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels
12. Neurochemical actions of anesthetic drugs on the gamma-aminobutyric acid receptor-chloride channel complex
13. Modulation of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex by inhalation anesthetics
14. Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the rat
15. Stereospecific actions of the inhalation anesthetic isoflurane at the GABAA receptor complex
16. Isoflurane's enhancement of chloride flux through rat brain gamma-aminobutyric acid type A receptors is stereoselective
17. 19F nuclear magnetic resonance investigation of stereoselective binding of isoflurane to bovine serum albumin
18. Can the stereoselective effects of the anesthetic isoflurane be accounted for by lipid solubility?