Headspace gas chromatography-mass spectrometry analysis of isoflurane enantiomers in blood samples after anesthesia with the racemic mixture

Chirality

Volumn 11, Issue 3, 1999, Pages 206-211

  Schmidt, R ^a   Wahl, H G ^b   Haberle H ^c   Dieterich, H J ^c   Schurig, V ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c Abteilung Anaesthesiologie   (Germany)

Author keywords

Enantioselectivity; Headspace GC MS; Isoflurane anesthesia; Isoflurane enantiomers in blood; SIM

Indexed keywords

CYCLODEXTRIN DERIVATIVE; ISOFLURANE;

ARTICLE; DRUG DETERMINATION; ENANTIOMER; GAS CHROMATOGRAPHY; GENERAL ANESTHESIA; HUMAN; MASS SPECTROMETRY; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ASSAY;

ANESTHESIA, INHALATION; ANESTHETICS, INHALATION; CHROMATOGRAPHY, ION EXCHANGE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; ISOFLURANE; QUALITY CONTROL; STEREOISOMERISM;

EID: 0033046785     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1999)11:3<206::AID-CHIR6>3.0.CO;2-R     Document Type: Article

References (20)

1. Franks NP, Lieb WR. Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels. Science 1991;254:427-430.
2. Harris B, Moody E, Skolnick P. Isoflurane anesthesia is stereoselective. Eur J Pharmacol 1992;217:215-216.
3. Lysko GS, Robinson JL, Casto R, Ferrone RA. The stereospecific effects of isoflurane isomers in vivo. Eur J Pharmacol 1994;263:25-29.
4. Hall AC, Lieb WR, Franks NP. Stereoselective and non-stereoselective actions of isoflurane on the GABAA receptor. BrJ Pharmacol 1994;112: 906-910.
5. 3H] isradipine binding to L-type calcium channels by the optical isomers of isoflurane. Anesthesiology 1994;81:124-128.
6. Graf BM, Boban M, Stowe DF, Kampine JP, Bosnjak ZJ. Lack of stereospecific effects of isoflurane and desflurane isomers in isolated guinea pig hearts. Anesthesiology 1994;81:129-136.
7. Morgan PG, Usiak MF, Sedensky MM. Genetic differences affecting the potency of stereoisomers of isoflurane. Anesthesiology 1996;85: 385-392.
8. Eger EI, Koblin DD, Laster MJ, Schurig V, Juza M, Ionescu P, Gong D. Minimum alveolar anesthetic concentration values for the enantiomers of isoflurane differ minimally. Anesth Analg 1997;85:188-192.
9. Juza M, Jakubetz H, Schurig V, Hettesheimer H. Qualitative and quantitative determination of inhaled isoflurane enantiomers from blood during and post surgery via headspace GC. Poster at the 18th International Symposium on Capillary Chromatography, Riva del Garda, May 20-24, 1996.
10. Ramsey JD, Flanagan RJ. Detection and identification of volatile organic compounds in blood by headspace gas chromatography as an aid to the diagnosis of solvent abuse. J Chromatogr 1982;:240:423-444.
11. Meinwald J, Thompson WR, Pearson DL, König WA, Runge T, Francke W. Inhalational anesthetics stereochemistry: optical resolution of halothane, enflurane, and isoflurane. Science 1991;251:560-561.
12. Schurig V, Grosenick H, Juza M. Enantiomer separation of chiral inhalation anesthetics (enflurane, isoflurane and desflurane) by gas chromatography on a γ-cyclodextrin derivative. Recl Trav Chim Pays-Bas 1995;114:211-219.
13. Frank H, Nicholson GJ, Bayer E. Enantiomer labelling, a method for the quantitative analysis of amino acids. J Chromatogr 1978;167:187-196.
14. Blair NE, Bonner WA. Quantitative determination of D ≠ L mixtures of optical enantiomers by gas chromatography. J Chromatogr 1980; 198:185-187.
15. Juza M, Braun E, Schurig V. Preparative enantiomer separation of the inhalation anesthetics enflurane, isoflurane and desflurane by gas chromatography on a derivatized γ-cyclodextrin stationary phase. J Chromatogr A 1997;769:119-127.
16. König WA, Krebber R, Mischnick PJ. Cyclodextrins as chiral stationary phases in capillary gas chromatography part V: octakis(3-O-butyryl-2,6-di-O-pentyl)-γ-cyclodextrin. J High Resolut Chromatogr 1989;12: 732-738.
17. Johnstone RAW, Rose ME, editors. Mass spectrometry for chemists and biochemists. Cambridge: Cambridge University Press; 1996. p. 215-216.
18. Eckenhoff RG, Shuman H. Halothane binding to soluble proteins determined by photoaffinity labeling. Anesthesiology 1993;79:96-106.
19. 19F-Nuclear magnetic resonance investigation of stereoselective binding of isoflurane to bovine serum albumin. Biophys J 1996;70:532-538.
20. Holaday DA, Fiserova-Bergerova V, Latto IP, Zumbiel MA. Resistance of isoflurane to biotransformation in man. Anesthesiology 1975;43:325-332.