Evasion from proteasomal degradation by mutated Fos proteins expressed from FBJ-MSV and FBR-MSV osteosarcomatogenic retroviruses

Biochemical Pharmacology

Volumn 64, Issue 5-6, 2002, Pages 957-961

  Acquaviva, Claire ^a   Bossis, Guillaume ^a   Ferrara, Patrizia ^a   Brockly, Frédérique ^a   Jariel Encontre, Isabelle ^a   Piechaczyk, Marc ^a  

^a INSTITUT DE GÉNÉTIQUE MOLÉCULAIRE DE MONTPELLIER   (France)

Author keywords

c Fos; Oncogene; Proteasome; Protein degradation; Retrovirus; Ubiquitin

Indexed keywords

FAS ANTIGEN; MUTANT PROTEIN; PROTEASOME; RETROVIRUS VECTOR; UBIQUITIN; VIRUS PROTEIN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC STABILITY; GENETIC TRANSDUCTION; HYDROLYSIS; MOLECULAR EVOLUTION; NONHUMAN; ONCOGENE C FOS; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY;

ANIMALS; CELL TRANSFORMATION, VIRAL; CYSTEINE ENDOPEPTIDASES; HUMANS; MULTIENZYME COMPLEXES; MUTATION; OSTEOSARCOMA; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-FOS; RETROVIRIDAE; VIRAL PROTEINS;

EID: 0036710466     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01159-0     Document Type: Article

References (45)

1. Mechta-Grigoriou F., Gerald D., Yaniv M. The mammalian Jun proteins: redundancy and specificity. Oncogene. 20:2001;2378-2389.
2. Shaulian E., Karin M. AP-1 in cell proliferation and survival. Oncogene. 20:2001;2390-2400.
3. Jochum W., Passegue E., Wagner E.F. AP-1 in mouse development and tumorigenesis. Oncogene. 20:2001;2401-2412.
4. van Dam H., Castellazzi M. Distinct roles of Jun:Fos and Jun:ATF dimers in oncogenesis. Oncogene. 20:2001;2453-2464.
5. Piechaczyk M., Blanchard J.M. c-fos proto-oncogene regulation and function. Crit. Rev. Oncol. Hematol. 17:1994;93-131.
6. Wisdom R. AP-1: one switch for many signals. Exp. Cell Res. 253:1999;180-185.
7. Curran T. The Fos oncogene. In: Reddy EP, Skalka A-M, Curran T, editors. The Oncogene Handbook. Amsterdam: Elsevier, 1988. p. 307-25.
8. Miao G.G., Curran T. Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle. Mol. Cell. Biol. 14:1994;4295-4310.
9. Ruther U., Garber C., Komitowski D., Muller R., Wagner E.F. Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature. 325:1987;412-416.
10. Ruther U., Komitowski D., Schubert F.R., Wagner E.F. c-fos expression induces bone tumors in transgenic mice. Oncogene. 4:1989;861-865.
11. Schmidt J., Krump-Konvalinkova V., Luz A., Goralczyk R., Snell G., Wendel S., Dorn S., Pedersen L., Strauss P.G., Erfle V. Akv murine leukemia virus enhances bone tumorigenesis in hMT-c-fos-LTR transgenic mice. Virology. 206:1995;85-92.
12. Van Beveren C., van Straaten F., Curran T., Muller R., Verma I.M. Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini. Cell. 32:1983;1241-1255.
13. Jotte R.M., Holt J.T. Myristylation of FBR v-fos dictates the differentiation pathways in malignant osteosarcoma. J. Cell. Biol. 135:1996;457-467.
14. Acquaviva C., Salvat C., Brockly F., Bossis G., Ferrara P., Piechaczyk M., Jariel-Encontre I. Cellular and viral Fos proteins are degraded by different proteolytic systems. Oncogene. 20:2001;7563-7572.
15. Curran T., Verma I.M. FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product. Virology. 135:1984;218-228.
16. Curran T., Miller A.D., Zokas L., Verma I.M. Viral and cellular fos proteins: a comparative analysis. Cell. 36:1984;259-268.
17. DeMartino G.N., Slaughter C.A. The proteasome, a novel protease regulated by multiple mechanisms. J. Biol. Chem. 274:1999;22123-22126.
18. Verma R., Deshaies R.J. A proteasome howdunit: the case of the missing signal. Cell. 101:2000;341-344.
19. Ciechanover A., Orian A., Schwartz A.L. Ubiquitin-mediated proteolysis: biological regulation via destruction. Bioessays. 22:2000;442-451.
20. Ciechanover A., Orian A., Schwartz A.L. The ubiquitin-mediated proteolytic pathway: mode of action and clinical implications. J. Cell. Biochem. 77:2000;40-51.
21. Pickart C.M. Ubiquitin enters the new millennium. Mol. Cell. 8:2001;499-504.
22. Acquaviva C., Brockly F., Ferrara P., Bossis G., Salvat C., Jariel-Encontre I., Piechaczyk M. Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos proto-oncoprotein during the G(0)-to-S phase transition. Oncogene. 20:2001;7563-7572.
23. Salvat C., Jariel-Encontre I., Acquaviva C., Omura S., Piechaczyk M. Differential directing of c-Fos and c-Jun proteins to the proteasome in serum-stimulated mouse embryo fibroblasts. Oncogene. 17:1998;327-337.
24. He H., Qi X.M., Grossmann J., Distelhorst C.W. c-Fos degradation by the proteasome. An early Bcl-2-regulated step in apoptosis. J. Biol. Chem. 273:1998;25015-25019.
25. Aniento F., Papavassiliou A.G., Knecht E., Roche E. Selective uptake and degradation of c-Fos and v-Fos by rat liver lysosomes. FEBS Lett. 390:1996;47-52.
26. Hirai S., Kawasaki H., Yaniv M., Suzuki K. Degradation of transcription factors, c-Jun and c-Fos by calpain. FEBS Lett. 287:1991;57-61.
27. Carillo S., Pariat M., Steff A.M., Roux P., Etienne-Julan M., Lorca T., Piechaczyk M. Differential sensitivity of FOS and JUN family members to calpains. Oncogene. 9:1994;1679-1689.
28. Watt F., Molloy P.L. Specific cleavage of transcription factors by the thiol protease, m-calpain. Nucleic Acids Res. 21:1993;5092-5100.
29. Roux P., Blanchard J.M., Fernandez A., Lamb N., Jeanteur P., Piechaczyk M. Nuclear localization of c-Fos, but not v-Fos proteins is controlled by extracellular signals. Cell. 63:1990;341-351.
30. Roux P, Carillo S, Blanchard J-M, Jeanteur P, Piechaczyk M. c-Fos protein transport into the nucleus. In: Angel P, Herrlich, P, editors. The Fos and Jun Families of Transcription Factors. Boca Raton, FL, USA: CRC Press, 1994. p. 87-95.
31. Hermida-Matsumoto M.L., Chock P.B., Curran T., Yang D.C. Ubiquitinylation of transcription factors c-Jun and c-Fos using reconstituted ubiquitinylating enzymes. J. Biol. Chem. 271:1996;4930-4936.
32. Stancovski I., Gonen H., Orian A., Schwartz A.L., Ciechanover A. Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes. Mol. Cell. Biol. 15:1995;7106-7116.
33. Jariel-Encontre I., Pariat M., Martin F., Carillo S., Salvat C., Piechaczyk M. Ubiquitinylation is not an absolute requirement for degradation of c-Jun protein by the 26 S proteasome. J. Biol. Chem. 270:1995;11623-11627.
34. Salvat C., Acquaviva C., Scheffner M., Robbins I., Piechaczyk M., Jariel-Encontre I. Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivo. Eur. J. Biochem. 267:2000;3712-3722.
35. Depraetere V. Getting activated with poly-ubiquitination. Nat. Cell. Biol. 3:2001;E181.
36. Okazaki K., Sagata N. The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. EMBO J. 14:1995;5048-5059.
37. Rogers S., Wells R., Rechsteiner M. Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science. 234:1986;364-368.
38. Rechsteiner M., Rogers S.W. PEST sequences and regulation by proteolysis. Trends Biochem. Sci. 21:1996;267-271.
39. Kamata N., Jotte R.M., Holt J.T. Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein. Mol. Cell. Biol. 11:1991;765-772.
40. Resh M.D. Myristylation and palmitylation of Src family members: the fats of the matter. Cell. 76:1994;411-413.
41. Jotte R.M., Kamata N., Holt J.T. Myristylation-dependent transactivation by FBR v-fos is regulated by C/EBP. J. Biol. Chem. 269:1994;16383-16396.
42. Abbott D.W., Holt J.T. Finkel-Biskis-Reilly osteosarcoma virus v-Fos inhibits adipogenesis and both the activity and expression of CCAAT/enhancer binding protein alpha, a key regulator of adipocyte differentiation. J. Biol. Chem. 272:1997;32454-32462.
43. Abbott D.W., Holt J.T. Finkel-Biskis-Reilly mouse osteosarcoma virus v-fos inhibits the cellular response to ionizing radiation in a myristoylation-dependent manner. J. Biol. Chem. 272:1997;14005-14008.
44. Kamata N., Holt J.T. Inhibitory effect of myristylation on transrepression by FBR (Gag-Fos) protein. Mol. Cell. Biol. 12:1992;876-882.
45. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell. 100:2000;57-70.