Myristylation of FBR v-fos dictates the differentiation pathways in malignant osteosarcoma

Journal of Cell Biology

Volumn 135, Issue 2, 1996, Pages 457-467

  Jotte, Robert M ^a,b   Holt, Jeffrey T ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 3; MYRISTIC ACID;

ANIMAL CELL; ARTICLE; CARCINOGENICITY; CELL DIFFERENTIATION; CONTROLLED STUDY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; TRANSGENIC MOUSE;

3T3 CELLS; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MOLONEY MURINE LEUKEMIA VIRUS; MYRISTIC ACID; MYRISTIC ACIDS; ONCOGENE PROTEINS V-FOS; OSTEOSARCOMA; POLYMERASE CHAIN REACTION; PROTEIN PROCESSING, POST-TRANSLATIONAL; REPETITIVE SEQUENCES, NUCLEIC ACID; SARCOMA VIRUSES, MURINE;

ANIMALIA; MUS MUSCULUS;

EID: 0029862191     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.135.2.457     Document Type: Article

References (33)

1. Barcellini-Couget, S., A. Pradines-Figueres, P. Roux, C. Dani, and G. Ailhaus. 1993. The regulation by growth hormone of lipoprotein lipase gene expresssion is mediated by c-fos protooncogene. Endocrinology. 132:53-60.
2. Chiang, P.K. 1981. Conversion of 3T3-L1 fibroblasts to fat cells by an inhibitor of methylation: effect of 3-deazaadenosine. Science (Wash. DC). 211:1164-1166.
3. Chirgwin, J.M., A.E. Przbyla, R.J. MacDonald, and W.J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294.
4. Coppola, J.A., and M.D. Cole. 1986. Constituitive c-myc oncogene expression blocks mouse erythroleukemia cell differentiation but not commitment. Nature (Lond.). 320:760-763.
5. Curran, T., and I.M. Verma. 1984. FBR v-fos murine oseteosarcoma virus. I. Molecular analysis and characterization of a 75.000-Da gag-fos fusion product. Virology. 135:218-228.
6. Distel, R.J., H.-S. Ro, B.S. Rosen, D.L. Groves, and B.M. Spiegelman. 1987. Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos. Cell. 49:835-844.
7. Finkel, M.P., C.A. Reilly, Jr., and B.O. Biskis. 1975. Viral etiology of bone cancer. Front. Radiat. Ther. Oncol. 10:28-39.
8. Graham, F., and A. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology. 52:456-467.
9. Herrera, R., H.S. Ro, G.S. Robinson, K.G. Xanthopoulos, and B.M. Spiegelman. 1989. A direct role for C/EBP and the AP-1-binding site in gene expression linked to adipocyte differentiation. Mol. Cell. Biol. 9:5331-5339.
10. Hogan, B., F. Constantini, and E. Lacy. 1986. Manipulating the Mouse Embryo: a Laboratory Manual. Cold Spring Harbor Press, Plainview, NY.
11. Jenuwein, T., and R. Müller. 1987. Structure-function analysis of fos protein: a single amino acid change activates the immortalizing potential of v-fos. Cell. 48:647-657.
12. Jenuwein, T., D. Miller, T. Curran, and R. Müller. 1985. Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV. Cell. 41:629-637.
13. Jotte, R.M., N. Kamata, and J.T. Holt. 1994. Myristylation dependent transactivation by FBR v-fos is regulated by C/EBP. J. Biol. Chem. 269:16383-16396.
14. Kamata, N., and J.T. Holt. 1992. Inhibitory effect of myristylation on transrepression by FBR (Gag-Fos) protein. Mol. Cell. Biol. 12:876-882.
15. Kamata, N., R.M. Jotte, and J.T. Holt. 1991. Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein. Mol. Cell. Biol. 11: 765-772.
16. Lassar, A.B., M.J. Thayer, R.W. Overell, and H. Weintraub. 1989. Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1. Cell. 58:659-667.
17. Lee, C.K., E.W. Chan, C.A. Reilly, V.A. Pahnke, G. Rockus, and M.P. Finkel. 1979. In vitro properties of FBR murine osteosarcoma virus. Proc. Soc. Exp. Biol. Med. 162:214-220.
18. Liau, G., Y. Yamada, and B. de Crombrugghe. 1985. Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts. J. Biol. Chem. 260:531-536.
19. Meijlink, F., T. Curran, A.D. Miller, and I.M. Verma. 1985. Removal of a 67 base pair sequence in the non-coding region of proto-oncogene fos converts it to a transforming gene. Proc. Natl. Acad. Sci. USA. 82:4987-4991.
20. Michiels, L., J.R. Maisin, F.S. Pedersen, and J. Merregaert. 1984. Characterization of the FBR-murine osteosarcoma virus complex: FBR-MuSV encodes a fos-derived oncogene. Int. J. Cancer. 33:511-517.
21. Price, C.H.G., M. Moore, and D.B. Jones. 1972. FBJ virus-induced tumours in mice. A histopathological study of FBJ virus tumours and their relevance to murine and human osteosarcoma. Br. J. Cancer. 26:15-27.
22. Rauscher, F.J., III, L.C. Sambucetti, T. Curran, R.J. Distel, and B.M. Spiegelman. 1988. Common DNA binding sites for fos protein complexes and transcription factor AP-1. Cell. 42:471-480.
23. Rüther, U., C. Garber, D. Komitowski, R. Müller, and E.F. Wagner. 1987. Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature (Lond.). 325:412-416.
24. Sager, R., and P. Kovac. 1982. Preadipocyte determination either by insulin or by 5-azacytidine. Proc. Natl. Acad. Sci. USA. 79:480-484.
25. Setoyama, C., R. Frunzio, G. Liau, M. Mudryj, and B. de Crombrugghe. 1986a. Transcriptional activation encoded by the v-fos gene. Proc. Natl. Acad. Sci. USA. 83:3213-3217.
26. Setoyama, C., A. Hatamochi, B. Peterkofsky, W. Prather, and B. de Crombrugghe. 1986b. v-fos stimulates expression of the alpha 1 (III) collagen gene in NIH 3T3 cells. Bio. Biophys. Res. Commun. 136:1042-1048.
27. Silbermann, M., J. Schmidy, E. Livne, K. von der Mark, and V. Erfle. 1987. In vitro induction of osteosarcoma-like lesions by transformation of differentiating skeletal precursor cells with FBR osteosarcoma virus. Calcif. Tissue Int. 44:208-217.
28. Thompson, M.E., R.A. Jensen, P.S. Obermiller, D.L. Page, and J.T. Holt. 1995. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat. Genet. 9:444-450.
29. Van Beveren, C., S. Enami, T. Curran, and I.M. Verma. 1984. FBR v-fos murine osteosarcoma virus. II. Nucleotide sequence of the provirus reveals that the genome contains sequences acquired from two cellular genes. Virology. 135:229-243.
30. Ward, J.M., and D.M. Young. 1976. Histogenesis and morphology of periosteal sarcomas induced by FBJ virus in NIH-Swiss mice. Cancer Res. 36:3985-3992.
31. Weiner, F.R., A. Shah, P.J. Smith, and C.S. Rubin. 1989. Regulation of collagen gene expression in 3T3-L1 cells. Effects of adipocyte differentiation and tumor necrosis factor alpha. Biochemistry. 28:4094-4099.
32. Wilson, T., and R. Treisman. 1988. fos C-terminal mutations block downregulation of c-fos transcription following serum stimulation. EMBO (Eur. Mol. Biol. Organ.) J. 7:4193-4202.
33. Yoakum, G.H., J.F. Lechner, E.W. Gabrielson, B.E. Korba, L. Malan-Shibley, J.C. Willey, A.M. Shamsuddin, B.F. Trump, and C.C. Harris. 1985. Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. Science (Wash. DC). 227:1174-1179.