Cells obtained from colorectal microadenomas mirror early premalignant growth patterns in vitro

European Journal of Cancer

Volumn 38, Issue 14, 2002, Pages 1937-1945

  Richter, M ^a   Jurek, D ^a   Wrba, F ^b   Kaserer, K ^b   Wurzer, G ^a   Karner Hanusch, J ^b   Marian, B ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Adenoma; Growth control; Human colon

Indexed keywords

AGAR; CANCER GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; INSULIN; PROTEIN P53;

ALLELE; ARTICLE; AUTOCRINE EFFECT; CANCER CELL; CANCER GROWTH; CELL CONTACT; CELL LINE; CELL STRAIN; CELL SURVIVAL; COLON ADENOMA; COLON POLYP; COLORECTAL CANCER; EPITHELIUM CELL; GENE MUTATION; GENETIC TRAIT; GENOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROADENOMA; ONCOGENE RAS; PRECANCER; PRIORITY JOURNAL; RECTUM ADENOMA; RECTUM POLYP; SUPPRESSOR GENE;

ADENOMA; APOPTOSIS; CELL DIVISION; COLONIC NEOPLASMS; FLOW CYTOMETRY; GENES, RAS; HUMANS; MUTATION; PRECANCEROUS CONDITIONS; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR CELLS, CULTURED;

EID: 0036710163     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(02)00158-2     Document Type: Article

References (26)

1. Weinstein I.B. Nonmutagenic mechanisms in carcinogenesis: role of protein kinase C in signal transduction and growth control. Environ. Health Perspect. 93:1991;175-179.
2. Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 61:1990;759-767.
3. Bird R.P. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett. 93:1995;55-71.
4. Muto T., Bussey H.J., Morson B.C. The evolution of cancer of the colon and rectum. Cancer. 36:1975;2251-2270.
5. Moss S.F., Liu T.C., Petrotos A., Hsu T.M., Gold L.I., Holt P.R. Inward growth of colonic adenomatous polyps. Gastroenterology. 111:1996;1425-1432.
6. Kahl Rainer P., Sedivy R., Marian B. Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control. Gastroenterology. 110:1996;1753-1759.
7. Partik G., Kahl-Rainer P., Sedivy R., Ellinger A., Bursch W., Marian B. Apoptosis in human colorectal tumours: ultrastructure and quantitative studies on tissue localization and association with bak expression. Virchows Arch. 432:1998;415-426.
8. Willson J.K., Bittner G.N., Oberley T.D., Meisner L.F., Weese J.L. Cell culture of human colon adenomas and carcinomas. Cancer Res. 47:1987;2704-2713.
9. Paraskeva C., Buckle B.G., Sheer D., Wigley C.B. The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients. Int. J. Cancer. 34:1984;49-56.
10. Leibovitz A., Stinson J.C., McCombs W.B. 3rd, McCoy C.E., Mazur K.C., Mabry N.D. Classification of human colorectal adenocarcinoma cell lines. Cancer Res. 36:1976;4562-4569.
11. Fogh J., Orfeo T., Tiso J., Sharkey F.E. Establishment of human colon carcinoma lines in nude mice. Exp. Cell Biol. 47:1979;136-144.
12. Kaserer K., Schmaus J., Bethge U.et al. Staining patterns of p53 immunohistochemistry and their biological significance in colorectal cancer. J. Pathol. 190:2000;450-456.
13. Mendelsohn J. Epidermal growth factor receptor as a target for therapy with antireceptor monoclonal antibodies. J. Natl Cancer Inst. Monogr. 13:1992;125-131.
14. Partik G., Hochegger K., Schorkhuber M., Marian B. Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro. J. Cancer Res. Clin. Oncol. 125:1999;379-388.
15. Schorkhuber M., Karner Hanusch J., Sedivy R.et al. Survival of normal colonic epithelial cells from both rats and humans is prolonged by coculture with rat embryo colonic fibroblasts. Cell Biol. Toxicol. 14:1998;211-223.
16. Coffey R.J. Jr., Goustin A.S., Soderquist A.M.et al. Transforming growth factor alpha and beta expression in human colon cancer lines. implications for an autocrine model Cancer Res. 47:1987;4590-4594.
17. Bodmer W.F., Bailey C.J., Bodmer J.et al. Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature. 328:1987;614-616.
18. Smith A.J., Stern H.S., Penner M.et al. Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons. Cancer Res. 54:1994;5527-5530.
19. Takayama T., Ohi M., Hayashi T.et al. Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology. 121:2001;599-611.
20. Arber N., Sutter T., Miyake M.et al. Increased expression of cyclin D1 and the Rb tumor suppressor gene in c- K-ras transformed rat enterocytes. Oncogene. 12:1996;1903-1908.
21. Arber N., Han E.K., Sgambato A.et al. A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes. Gastroenterology. 113:1997;1892-1900.
22. Wu X., Fan Z., Masui H., Rosen N., Mendelsohn J. Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J. Clin. Invest. 95:1995;1897-1905.
23. Brinkmann V., Foroutan H., Sachs M., Weidner K.M., Birchmeier W. Hepatocyte growth factor/scatter factor induces a variety of tissue- specific morphogenic programs in epithelial cells. J. Cell Biol. 131:1995;1573-1586.
24. Richter M., Ebermann R., Marian B. Quercetin-induced apoptosis in colorectal tumor cells: Possible role of EGF receptor signaling. Nutr. Cancer Int. J. 34:1999;88-99.
25. Habel O, Bertario L, Adreola S, Sirizotti G, Marian B. Apoptosis and the tissue localization of TGF-alpha and the EGF-receptor in colorectal tumors. Histochem Cell Biol 2002, 117, 235-242.
26. Richter M., Weiss M., Weinberger I., Furstenberger G., Marian B. Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors. Carcinogenesis. 22:2001;17-25.