Neurokinins activate local glutamatergic inputs to serotonergic neurons of the dorsal raphe nucleus

Neuropsychopharmacology

Volumn 27, Issue 3, 2002, Pages 329-340

  Liu, Rongjian ^a   Ding, Yuqiang ^b   Aghajanian, George K ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

EPSC; Glutamatergic neuron; Neurokinin; NK1 receptors; NK3 receptors; Raphe; Serotonin

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR ANTAGONIST; KAINIC ACID RECEPTOR ANTAGONIST; NEUROKININ; NEUROKININ 1 RECEPTOR; NEUROKININ 3 RECEPTOR; SEROTONIN; SODIUM CHANNEL BLOCKING AGENT; SUBSTANCE P; TETRODOTOXIN;

ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; DESENSITIZATION; DORSAL RAPHE NUCLEUS; DRUG MECHANISM; EXCITATORY POSTSYNAPTIC POTENTIAL; MALE; NEUROTRANSMISSION; NONHUMAN; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR BLOCKING; SEROTONINERGIC NERVE CELL; SIGNAL TRANSDUCTION;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; AFFERENT PATHWAYS; ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; FLUORESCENT ANTIBODY TECHNIQUE; GLUTAMIC ACID; MALE; NEURONS; PEPTIDE FRAGMENTS; PHENYLEPHRINE; RAPHE NUCLEI; RATS; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-3; RECEPTORS, SEROTONIN; SUBSTANCE P; TACHYKININS; TETRODOTOXIN;

EID: 0036710083     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(02)00305-6     Document Type: Article

References (53)

1. Aghajanian G.K., VanderMaelen C.P. Intracellular identification of central noradrenergic and serotonergic neurons by a new double labeling procedure. J Neurosci. 2:1982;1786-1792.
2. Aghajanian G.K., Lakoski J.M. Hyperpolarization of serotonergic neurons by serotonin and LSD. studies in brain slices showing increased K+ conductance Brain Res. 305:1984;181-185.
3. Aguiar M.S., Brandao M.L. Effects of microinjections of the neuropeptide substance P in the dorsal periaqueductal gray on the behaviour of rats in the plus-maze test. Physiol Behav. 60:1996;1183-1186.
4. Baraban J.M., Wang R.Y., Aghajanian G. Reserpine suppression of dorsal raphe neuronal firing. mediation by adrenergic system Eur J Pharmacol. 52:1978;27-36.
5. Buell G., Schulz M.F., Arkinstall S.J., Maury K., Missotten M., Adami N., Talabot F., Kawashima E. Molecular characterization, expression and localization of human neurokinin-3 receptor. FEBS Lett. 299:1992;90-95.
6. 2+ conductance Synapse. 1:1987;582-588.
7. Chaput Y., de Montigny C., Blier P. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors. electrophysiological studies in the rat brain Naunyn Schmiedebergs Arch Pharmacol. 333:1986;342-348.
8. Cuello A.C., Kanazawa I. The distribution of substance P immunoreactive fibers in the rat central nervous system. J Comp Neurol. 178:1978;129-156.
9. Culman J., Unger T. Central tachykinins. mediators of defense and stress reactions J Physiol Pharmacol. 73:1995;885-891.
10. Dahlström A., Fuxe K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Act Physiol Scand. 62:1964;1-55.
11. 3) in the central nervous system of the rat. J Comp Neurol. 364:1996;290-310.
12. 1 receptor antagonist in the social interaction test. Pharmacol Biochem Behav. 58:1997;747-752.
13. Fong T.M., Yu H., Strader C.D. Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580. J Biol Chem. 267:1992;25668-25671.
14. Forchetti C.M., Marco E.J., Meek J.L. Serotonin and gamma-aminobutyric acid turnover after injection into the median raphe of substance P and D-Ala-Met-enkephalin amide. J Neurochem. 38:1982;1336-1341.
15. Froger N., Gardier A.M., Moratalla R., Alberti I., Lena I., Boni C., De Felipe C., Rupniak N.M., Hunt S.P., Jacquot C., Hamon M., Lanfumey L. 5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization. J Neurosci. 21:2001;8188-8197.
16. Gallager D.W., Aghajanian G.K. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system. Eur J Pharmacol. 39:1976;341-355.
17. Garret C., Carruette A., Fardin V., Moussaoui S., Peyronel J.F., Blanchard JC Laduron PM Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc Natl Acad Sci USA. 88:1991;208-212.
18. Goodman L.A. Kolmogorov-Smirnov tests for psychological research. Psychol Bull. 51:1954;160-168.
19. Gradin K., Qadri F., Nomikos G.G., Hillegaart V., Svensson T.H. Substance P injection into the dorsal raphe increases blood pressure and serotonin release in hippocampus of conscious rats. Eur J Pharmacol. 218:1992;363-367.
20. Horwell D.C. The 'peptoid' approach to the design of nonpeptide, small molecule agonists and antagonists of neuropeptides. TIBTECH. 13:1995;132-134.
21. Iversen L.L., McNight A.T., Foster A.C., Young S.C., Williams B.J. Pharmacology of the tachykinin system. Schwartz T.W., Hilsted L.M., Rehfeld J.F. Neuropeptides and Their Receptors. 1990;363-372 Munksgaard, Copenhagen.
22. Jolas T., Aghajanian G.K. Neurotensin excitation of serotonergic neurons in the dorsal raphe nucleus of the rat in vitro. Eur J Neurosci. 8:1996;153-161.
23. Jolas T., Aghajanian G.K. Opioids suppress spontaneous and NMDA-induced inhibitory postsynaptic currents in the dorsal raphe nucleus of the rat in vitro. Brain Res. 755:1997;229-245.
24. Kramer M.S., Cutler N., Feighner J., Shrivastava R., Carman J., Sramek J.J., Reines S.A., Liu G., Snavely D., Wyatt-Knowles E., Hale J.J., Mills S.G., MacCoss M., Swain C.J., Harrison T., Hill R.G., Hefti F., Scolnick E.M., Cascieri M.A., Chicchi G.G., Sadowski S., Williams A.R., Hewson L., Smith D., Carlson E.J., Hargreaves R.J., Rupniak N.M. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science. 281:1998;1640-1645.
25. Laufer R., Gilon C., Chorev M., Selinger Z. Characterization of a neurokinin B receptor site in rat brain using a highly selective radioligand. J Biol Chem. 261:1986;10257-10263. a.
26. Laufer R., Gilon C., Chorev M., Selinger Z. SP6-11, a selective agonist for the substance P P-receptor subtype. J Med Chem. 29:1986;1284-1288. b [pGlu6, Pro9].
27. Laufer R., Gilon C., Chorev M., Selinger Z. Desensitization with a selective agonist discriminates between multiple tachykinin receptors. J Pharmacol Exp Ther. 245:1988;639-643.
28. Lucas L.R., Hurley D.L., Krause J.E., Harlan R.E. Localization of the tachykinin neurokinin B precursor peptide in rat brain by immunocytochemistry and in situ hybridization. Neuroscience. 51:1992;317-345.
29. Maeno H., Kiyama H., Tohyama M. Distribution of the substance P receptor (NK-1 receptor) in the central nervous system. Mol Brain Res. 18:1993;43-58.
30. Maggi C.A., Patacchini R., Rovero P., Giachett A. Tachykinin receptors and tachykinin receptor antagonists. J Auto Pharmacol. 13:1993;23-93.
31. Marksteiner J., Sperk G., Krause J.E. Distribution of neurons expressing neurokinin B in the rat brain. immunohistochemistry and in situ hybridization J Comp Neurol. 317:1992;341-356.
32. Mileusnic D., Lee J.M., Magnuson D.J., Hejna M.J., Krause J.E., Lorens J.B., Lorens S.A. Neurokinin-3 receptor distribution in rat and human brain. An immunohistochemical study Neuroscience. 89:1999;1269-1290.
33. Nakanishi S. Mammalian tachykinin receptors. Annu Rev Neurosci. 14:1991;123-136.
34. Paris J.M., Lorens S.A. Intra-median raphe infusions of muscimol and the substance P analogue DiMe-C7 produce hyperactivity. role of serotonin neurons Behav Brain Res. 26:1987;139-151.
35. Paris J.M., Mitsushio H., Lorens S.A. Intra-raphe neurokinin-induced hyperactivity. effects of 5,7-dihydroxytryptamine lesions Brain Res. 476:1989;183-188.
36. Regoli D., Boudon A., Fauchere J.L. Receptors and antagonists for substance P related peptides. Pharmacol Rev. 46:1994;551-599.
37. 3H]serotonin release in the basal ganglia of the cat. Brain Res. 236:1982;317-327.
38. 3H-5-hydroxytryptamine from rat substantia nigra in vitro. Naunyn Schmiedebergs Arch Pharmacol. 304:1978;271-275.
39. Ribeiro S.J., Teixeira R.M., Calixto J.B., De Lima T.C. Tachykinin NK(3) receptor involvement in anxiety. Neuropeptides. 33:1999;181-188.
40. Santarelli L., Gobbi G., Debs P.C., Sibille E.T., Blier P., Hen R., Heath M.J. Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci USA. 98:2001;1912-1917.
41. Sarau H.M., Griswold D.E., Potts W., Foley J.J., Schmidt D.B., Webb E.F., Martin L.D., Brawner M.E., Elshourbagy N.A., Medhurst A.D., Giardina G.A., Hay D.W. Nonpeptide tachykinin receptor antagonists. I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist J Pharmacol Exp Ther. 281:1997;1303-1311.
42. Seabrook G.R., Bowery B.J., Hill R.G. Pharmacology of tachykinin receptors on neurons in the ventral tegmental area of rat brain slices. Eur J Pharmacol. 273:1995;113-119.
43. Shindler K.S., Roth K.A. Double immunofluorescent staining using two unconjugated primary antisera raised in the same species. J Histochem Cytochem. 44:1996;1331-1335.
44. 3H] serotonin release from rat cerebral cortex by neuromedin K and substance P acting at distinct receptor sites Brain Res. 401:1987;377-380.
45. 3 receptors. Neuropeptides. 27:1994;333-341.
46. Stoessl A.J., Dourish C.T., Young S.C., Williams B.J., Iversen S.D., Iversen L.L. Senktide, a selective neurokinin B-like agonist, elicits serotonin-mediated behaviour following intracisternal administration in the mouse. Neurosci Lett. 80:1987;321-326.
47. Stoessl A.J., Dourish C.T., Iversen S.D. The NK-3 tachykinin receptor agonist senktide elicits 5-HT-mediated behaviour following central or peripheral administration in mice and rats. Br J Pharmacol. 94:1988;285-287.
48. Stoessl A.J., Dourish C.T., Iversen S.D. Pharmacological characterization of the behavioural syndrome induced by the NK-3 tachykinin agonist senktide in rodents. evidence for mediation by endogenous 5-HT Brain Res. 517:1990;111-116.
49. 1 receptor antagonists as potential antidepressants. Annu Rev Pharmacol Toxicol. 41:2001;877-906.
50. Teixeira R.M., Santos A.R., Ribeiro S.J., Calixto J.B., Rae G.A., De Lima T.C. Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice. Eur J Pharmacol. 311:1996;7-14.
51. Ungerstedt U. Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand (Suppl. 367):1971;1-48.
52. VanderMaelen C.P., Aghajanian G.K. Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Res. 289:1983;109-119.
53. Wormser U., Laufer R., Hart Y., Chorev M., Gilon C., Selinger Z. Highly selective agonists for substance P receptor subtypes. EMBO J. 5:1986;2805-2808.