TGFβ regulates the expression of Gαi2 via an effect on the localization of ras

Journal of Molecular and Cellular Cardiology

Volumn 34, Issue 9, 2002, Pages 1217-1226

  Ward, Simone M ^a   Gadbut, Albert P ^a   Tang, Dongjiang ^a   Papageorge, Alexer G ^b   Wu, Leeying ^a   Li, Guangde ^a   Barnett, Joey V ^a   Galper, Jonas B ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Atrial myocytes; G i2; Parasympathetic response; Ras; TGF

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA; CARBACHOL; CARDIOTONIC AGENT; DRUG DERIVATIVE; ENZYME INHIBITOR; FARNESOL; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; ONCOPROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; CHICKEN; CHOLINERGIC TRANSMISSION; CHRONOTROPISM; GENETIC REGULATION; HEART ATRIUM MUSCLE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILE FORCE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR BINDING; ANIMAL; CELL CULTURE; CHICK EMBRYO; CHOLINERGIC SYSTEM; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; HEART ATRIUM; HEART RATE; METABOLISM; PRENATAL DEVELOPMENT;

ANIMALS; CARBACHOL; CARDIOTONIC AGENTS; CELLS, CULTURED; CHICK EMBRYO; ENZYME INHIBITORS; FARNESOL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEART ATRIA; HEART RATE; METHIONINE; MYOCYTES, CARDIAC; PARASYMPATHETIC NERVOUS SYSTEM; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; RAS PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036708606     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2828(02)92073-0     Document Type: Article

References (31)

1. Schwartz PJ, La Rovere MT, Vanoli E. Autonomic nervous system and sudden cardiac death. Experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation 1992; 85: 177-191.
2. Eschenhagen T, Mende U, Diederich M, Hertle B, Memmesheimer C, Pohl A, Schmitz W, Scholz H, Steinfath M, Bohm M, Michel MC, Brodde OE, Raap A. Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia. Circulation 1996; 93: 763-771.
3. Galper JB, Barnett JV, Kilbourne E, Gadbut AP. Physiology and Pathophysiology of the Heart. Boston: Kluwer Academic Publishers; 1995.
4. Wickman KD, Clapham DE. G-protein regulation of ion channels. Curr Opin Neurobiol 1995: 5: 278-285.
5. Haigh LS, Leatherman GF, O'Hara DS, Smith TW, Galper JB. Effects of low density lipoproteins and mevinolin on cholesterol content and muscarinic cholinergic responsiveness in cultured chick atrial cells. Regulation of levels of muscarinic receptors and guanine nucleotide regulatory proteins. J Biol Chem 1988: 263: 15608-15618.
6. Barnett JV, Haigh LS, Marsh JD, Galper JB. Effects of low density lipoproteins and mevinolin on sympathetic responsiveness in cultured chick atrial cells. Regulation of beta-adrenergic receptors and alpha s. J Biol Chem 1989: 264: 10779-10786.
7. Gadbut AP, Wu L, Tang D, Papageorge A, Watson JA, Galper JB. Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. Embo J 1997; 16: 7250-7260.
8. Liang BT, Hellmich MR, Neer EJ, Galper JB. Development of muscarinic cholinergic inhibition of adenylate cyclase in embryonic chick heart. Its relationship to changes in the inhibitory guanine nucleotide regulatory protein. J Biol Chem 1986: 261: 9011-9021.
9. Donahue JK, Heldman AW, Fraser H, McDonald AD, Miller JM, Rade JJ, Eschenhagen T, Marban E. Focal modification of electrical conduction in the heart by viral gene transfer. Nat Med 2000; 6: 1395-1398.
10. Howe PH, Dobrowolski SF, Reddy KB, Stacey DW. Release from G1 growth arrest by transforming growth factor beta 1 requires cellular ras activity. J Biol Chem 1993: 268: 21448-21452.
11. Mulder KM, Morris SL. Activation of p21ras by transforming growth factor beta in epithelial cells. J Biol Chem 1992: 267: 5029-5031.
12. Hori Y, Kikuchi A, Isomura M, Katayama M, Miura Y, Fujioka H, Kaibuchi K, Takai Y. Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins. Oncogene 1991: 6: 515-522.
13. Casey PJ, Solski PA, Der CJ, Buss JE. p21ras is modified by a farnesyl isoprenoid. Proc Natl Acad Sci USA 1989; 86: 8323-8327.
14. Brown MS, Goldstein JL. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J Lipid Res 1980; 21: 505-517.
15. Clarke S. Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu Rev Biochem 1992; 61: 355-386.
16. Haddad EB, Rousell J, Mak JC, Barnes PJ. Transforming growth factor-beta 1 induces transcriptional down- regulation of m2 muscarinic receptor gene expression. Mol Pharmacol 1996; 49: 781-787.
17. Jackson DA, Nathanson NM. Regulation of expression and function of m2 and m4 muscarinic receptors in cultured embryonic chick heart cells by transforming growth factor-beta 1. Biochem Pharmacol 1997; 54: 525-527.
18. Serra R, Verderame MF, Isom HC. Transforming growth factor beta 1 partially suppresses the transformed phenotype of ras-transformed hepatocytes. Cell Growth Differ 1992; 3: 693-704.
19. Diaz-Meco MT, Dominguez I, Sanz L, Municio MM, Berra E, Cornet ME, Garcia de Herreros A, Johansen T, Moscat J. Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals. Mol Cell Biol 1992; 12: 302-308.
20. DeHaan RL. Development of form in the embryonic heart. An experimental approach. Circulation 1967; 35: 821-833.
21. Gadbut AP, Toupin DK, Kilbourne EJ, Galper JB. Low density lipoproteins induce parasympathetic responsiveness in embryonic chick ventricular myocytes in parallel with a coordinate increase in expression of genes coding for the M2 muscarinic receptor, G alpha i2, and the acetylcholine-sensitive K+ channel. J Biol Chem 1994; 269: 30707-30712.
22. Kilbourne EJ, Galper JB. Cloning of cDNAs coding for the G alpha i1 and G alpha i2 G-proteins from chick brain. Gene 1994; 150: 341-344.
23. Sambrook J, Fritsh EF, Maniatis T. Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor: 1990.
24. Holtzman EJ, Soper BW, Stow JL, Ausiello DA, Ercolani L. Regulation of the G-protein alpha i-2 subunit gene in LLC-PK1 renal cells and isolation of porcine genomic clones encoding the gene promoter. J Biol Chem 1991; 266: 1763-1771.
25. Feig LA, Cooper GM. Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol Cell Biol 1988: 8: 3235-3243.
26. Zhang K, Papageorge AG, Lowy DR. Mechanistic aspects of signaling through Ras in NIH 3T3 cells. Science 1992: 257: 671-674.
27. Qiu MS, Pitts AF, Winters TR, Green SH. ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells. J Cell Biol 1991; 115: 795-808.
28. Crick DC, Andres DA, Waechter CJ. Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation. Biochem Biophys Res Commun 1997; 237: 483-487.
29. Vogt A, Qian Y, McGuire TF, Hamilton AD, Sebti SM. Protein geranylgeranylation, not farnesylation. is required for the G1 to S phase transition in mouse fibroblasts. Oncogene 1996: 13: 1991-1999.
30. Hanatani A, Yoshiyama M, Kim S, Omura T, Ikuno Y, Takeuchi K, Iwao H, Yoshikawa J. Assessment of cardiac function and gene expression at an early phase after myocardial infarction. Jpn Heart J 1998: 39: 375-388.
31. Seko Y, Nishimura H, Takahashi N, Ashida T, Nagai R. Serum levels of vascular endothelial growth factor and transforming growth factor-beta1 in patients with atrial fibrillation undergoing defibrillation therapy. Jpn Heart J 2000: 41: 27-32.