The lumenal domain of the integral membrane protein phogrin mediates targeting to secretory granules

Traffic

Volumn 3, Issue 9, 2002, Pages 654-665

  Wasmeier, Christina ^a   Bright, Nicholas A ^b   Hutton, John C ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Dense core granule; Granule membrane protein; Neuroendocrine; Regulate secretion; Sorting signal

Indexed keywords

CYSTEINE; MEMBRANE PROTEIN; PROTEIN PHOGRIN; UNCLASSIFIED DRUG; CYCLOHEXIMIDE; PRIMER DNA; PROTEIN TYROSINE PHOSPHATASE; PTPRN2 PROTEIN, HUMAN; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOCHEMISTRY; BIOGENESIS; CELL FUNCTION; CELL STRUCTURE; CONTROLLED STUDY; DELETION MUTANT; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN TARGETING; REGULATORY MECHANISM; SECRETORY GRANULE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; ELECTRON MICROSCOPY; FLUORESCENCE MICROSCOPY; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CELL LINE; CYCLOHEXIMIDE; DNA PRIMERS; HUMAN; MEMBRANE PROTEINS; MICE; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; HUMANS;

EID: 0036707866     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2002.30907.x     Document Type: Article

References (63)

1. Constitutive and regulated secretion of proteins
2. The trans-most cisternae of the Golgi complex: A compartment for sorting of secretary and plasma membrane proteins
3. Cell-free protein sorting to the regulated and constitutive secretory pathways
4. Biogenesis of secretory granules in the trans-Golgi network of neuroendocrine and endocrine cells
5. Protein targeting via the 'constitutive-like' sectory pathway in isolated pancreatic islets: Passive sorting in the immature granule compartment
6. Differential sorting of lysosomal enzymes out of the regulated secretary pathway in pancreatic beta-cells
7. Interaction of furin in immature secretory granules from neuroendocrine cells with the AP-1 adaptor complex is modulated by casein kinase II phosphorylation
8. Protein secretion: Puzzling receptors
9. Sorting and storage during secretory granule biogenesis: Looking backward and looking forward
10. Signal-mediated sorting of neuropeptides and prohormones: Secretory granule biogenesis revisited
11. Secretory granule biogenesis: Rafting to the SNARE
12. Concentrating hormones into secretory granules: Layers of control
13. The amino-terminal sequence of pro-opiomelanocortin directs intracellular targeting to the regulated secretory pathway
14. Identification of the sorting signal motif within pro-opiomelanocortin for the regulated secretory pathway
15. Reduction of the disulfide bond of chromogranin B (secretogranin I) in the trans-Golgi network causes its missorting to the constitutive secretory pathways
16. Essential role of the disulfide-bonded loop of chromogranin B for sorting to secretory granules is revealed by expression of a deletion mutant in the absence of endogenous granin synthesis
17. The propeptice of preprosomatostatin mediates intracellular transport and secretion of alpha-globin from mammalian cells
18. Identification of a transferable sorting domain for the regulated pathway in the prohormone convertase PC2
19. The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments
20. Carboxypeptidase E is a regulated secretory pathway sorting receptor: Genetic obliteration leads to endocrine disorders in Cpe (fat) mice
21. Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A
22. Ca2 (+) -induced conformational change and aggregation of chromogranin A
23. Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network
24. pH- and Ca (2+) -induced conformational change and aggregation of chromogranin B. Comparison with chromogranin A and implication in secretory vesicle biogenesis
25. The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation
26. Calcium- and pH-dependent aggregation and membrane association of the precursor of the prohormone convertase PC2
27. Calcium- and pH-dependent aggregation of carboxypeptidase E
28. Carboxypeptidase E, a peripheral membrane protein implicated in the targeting of hormones to secretory granules, co-aggregates with granule content proteins at acidic pH
29. Secretory granule content proteins and the luminal domains of granule membrane proteins aggregate in vitro at mildly acidic pH
30. The disulfide bond in chromogranin B, which is essential for its sorting to secretory granules, is not required for its aggregation in the trans-Golgi network
31. The disulfide-bonded loop of chromogranin B mediates membrane binding and directs sorting from the trans-Golgi network to secretory granules
32. Chromogranin 8 (secretogranin I ), a secretory protein of the regulated pathway, is also present in a tightly membrane-associated form in PC12 cells
33. pH-dependent association of chromogranin A with secretory vesicle membrane and a putative membrane binding region of chromogranin A
34. Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10)
35. The C-terminal region of carboxypeptidase E involved in membrane binding is distinct from the region involved with intracellular routing
36. The propeptide of prohormone convertase PC2 acts as a transferable aggregation and membrane-association signal
37. Lipid raft association of carboxypeptidase E is necessary for its function as a regulated secretory pathway sorting receptor
38. Involvement of the membrane lipid bilayer in sorting prohormone convertase 2 into the regulated secretory pathway
39. Expression of individual forms of peptidylglycine alpha-amidating monooxygenase in AtT-20 cells: Endoproteolytic processing and routing to secretory granules
40. Differential trafficking of soluble and integral membrane secretory granule-associated proteins
41. COOH-terminal signals mediate the trafficking of a peptice processing enzyme in endocrine cells
42. Identification of routing determinants in the cytosolic domain of a secretory granule-associated integral membrane protein
43. Cytoplasmic domain of P-selectin (CD62) contains the signal for sorting into the regulated secretory pathway
44. Targeting of P-selectin to two regulated secretory organelles in PC12 cells
45. Determinants in the cytoplasmic domain of P-selectin required for sorting to secretory granules
46. A complex web of signal-dependent trafficking underlies the triorganellar distribution of P-selectin in neuroendocrine PC12 cells
47. Molecular cloning of phogrin, a protein tyrosine phosphatase homologue localized to insulin secretory granule membranes
48. Secretory-granule dynamics visualized in vivo with a phogringreen fluorescent protein chimaera
49. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
50. ICA512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules
51. IDA-1, a Caenorhabditts elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm
52. Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue
53. Secretagogue-dependent phosphorylation of the insulin granule membrane protein phogrin is mediated by cAMP-dependent protein kinase
54. An antibody specific for an endoproteolytic cleavage site provides evidence that pro-opiomelanocortin is packaged into secretory granules in AtT20 cells before its cleavage
55. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor
56. Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans
57. A C-terminal signal prevents secretion of luminal ER proteins
58. Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors
59. Exocytotic exposure and recycling of membrane antigens of chromaffin granules: Ultrastructural evaluation after immunolabeling
60. Recycling of a secretory granule membrane protein after stimulated secretion
61. Dense core lysosomes can fuse with late enclosomes and are re-formed from the resultant hybrid organelles
62. Improving structural integrity of cryosections for immunogold labelling
63. Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans