Epinephrine does not reduce the plasma concentration of lidocaine during continuous epidural infusion in children

Canadian Journal of Anesthesia

Volumn 49, Issue 7, 2002, Pages 706-710

  Miyabe, Masayuki ^a   Kakiuchi, Yoshihiro ^a   Inomata, Shinichi ^a   Ohsaka, Yoshiko ^a   Kohda, Yukinao ^a   Toyooka, Hidenori ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; DEETHYLLIDOCAINE; DRUG METABOLITE; LIDOCAINE; NITROUS OXIDE; OXYGEN; RINGER LACTATE SOLUTION; SEVOFLURANE; VECURONIUM;

ANESTHESIA INDUCTION; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CONTINUOUS EPIDURAL ANESTHESIA; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; PEDIATRIC ANESTHESIA; PRESCHOOL CHILD; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0036700302     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03017450     Document Type: Article

References (20)

1. Berde CB. Convulsions associated with pediatric regional anesthesia. Anesth Analg 1992; 75: 164-6.
2. Miyabe M, Kakiuchi Y, Kibara S, et al. The plasma concentration of lidocaine's principal metabolite increases during continuous epidural anesthesia in infants and children. Anesth Analg 1998; 87: 1056-7.
3. Braid DP, Scott DB. The systemic absorption of local analgesic drugs. Br J Anaesth 1965; 37: 394-404.
4. Tucker GT, Mather LE. Pharmacokinetics of local anaesthetic agents. Br J Anaesth 1975; 47: 213-24.
5. Mather LE, Tucker GT, Murphy TM, Stanton-Hicks MD, Bonica JJ. The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia II: pharmakokinetics. Br J Anaesth 1976; 48: 989-94.
6. Takasaki M, Kajitani H. Plasma lidocaine concentrations during continuous epidural infusion of lidocaine with and without epinephrine. Can J Anaesth 1990; 37: 166-9.
7. Kihara S, Miyabe M, Kakiuchi Y, et al. Plasma concentrations of lidocaine and its principal metabolites during continuous epidural infusion of lidocaine with or without epinephrine. Reg Anesth Pain Med 1999; 24: 529-33.
8. Kohda Y, Kakiuchi Y, Miyabe M, Sato S, Toyooka H, Sagara E. Simultaneous determination of lidocaine and its deethyl-metabolites in plasma and its application to drug level monitoring in infants. J Appl Ther Res 1998; 2: 33-8.
9. 1-acid glycoprotein concentration on the accumulation of lidocaine metabolites during continuous epidural anesthesia in infants and children. Int J Clin Pharmacol Ther 1999; 37: 493-8.
10. Tucker GT, Mather LE. Clinical pharmacokinetics of local anaesthetics. Clin Pharmacokinet 1979; 4: 241-78.
11. Scott DB, Jebson PJR, Braid DP, Örtengren B, Frisch P. Factors affecting plasma levels of lignocaine and prilocaine. Br J Anaesth 1972; 44: 1040-9.
12. Sharrock NE, Go G, Mineo R. Effect of i.v. low-dose adrenaline and phenylephrine infusions on plasma concentrations of bupivacaine after lumbar extradural anaesthesia in elderly patients. Br J Anaesth 1991; 67: 694-8.
13. Ward RJ, Bonica JJ, Freund FG, Akamatsu T, Danziger F, Englesson S. Epidural and subarachnoid anesthesia. Cardiovascular and respiratory effects. JAMA 1965; 191: 275-8.
14. Burm AGL, van Kleef JW, Gladines MPRR, Olthof G, Spierdijk J. Epidural anesthesia with lidocaine and bupivacaine: effects of epinephrine on the plasma concentration profiles. Anesth Analg 1986; 65: 1281-4.
15. Kozody R, Palahniuk RJ, Wade JG, Cumming MO, Pucci WR. The effect of subarachnoid epineprine and phenylephrine on spinal cord blood flow. Can Anaesth Soc J 1984: 31; 503-8.
16. Blumer J, Strong JM, Atkinson AJ Jr. The convulsant potency of lidocaine and its N-dealkylated metabolites. J Pharmacol Exp Ther 1973; 186: 31-6.
17. Drayer DE, Lorenzo B, Werns S, Reidenberg MM. Plasma levels, protein binding, and elimination data of lidocaine and active metabolites in cardiac patients of various ages. Clin Pharmacol Ther 1983; 34: 14-22.
18. Strong JM, Atkinson AJ Jr. Simultaneous measurement of plasma concentrations of lidocaine and its desethylated metabolite by mass fragmentography. Anal Chem 1972; 44: 2287-90.
19. Nation RL, Triggs EJ, Selig M. Lignocaine kinetics in cardiac patients and aged subjects. Br J Clin Pharmacol 1977; 4: 439-48.
20. Savarese JJ, Covino BG. Basic and clinical pharmacology of local anesthetic drugs. In: Miller RD (Ed.). Anesthesia, 2nd ed. New York: Churchill Livingstone Inc., 1986: 985-1013.