Plasma concentrations of lidocaine and its principal metabolites during continuous epidural infusion of lidocaine with or without epinephrine

Regional Anesthesia and Pain Medicine

Volumn 24, Issue 6, 1999, Pages 529-533

  Kihara, Shin Ichi ^a   Miyabe, Masayuki ^a   Kakiuchi, Yoshihiro ^a   Takahashi, Shinji ^a   Fukuda, Taeko ^a   Kohda, Yukinao ^a   Toyooka, Hidenori ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Epidural anesthesia; Epinephrine; Lidocaine

Indexed keywords

ADRENALIN; DEETHYLLIDOCAINE; DRUG METABOLITE; GLYCINE XYLIDIDE; LIDOCAINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS EPIDURAL ANESTHESIA; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MIXTURE; EPIDURAL DRUG ADMINISTRATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0032760449     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1098-7339(99)90044-5     Document Type: Article

References (24)

1. Braid DP, Scott DB. The systemic absorption of local analgesic drugs. Br J Anaesth 1965: 37: 394-404.
2. Tucker GT, Mather LE. Pharmacokinetics of local anaesthetic agents. Br J Anaesth 1975: 47: 213-224.
3. Mather LE, Tucker GT, Murphy TM, Stanton-Hicks M, Bonica JJ. The effects of adding adrenaline to etidocaine and lignocaine in extradural anaesthesia II: pharmacokinetics. Br J Anaesth 1976: 48: 989-994.
4. Takasaki M, Kajitani H. Plasma lidocaine concentrations during continuous epidural infusion of lidocaine with and without epinephrine. Can J Anaesth 1990: 37(2): 166-169.
5. Kohda Y, Kakiuchi Y, Miyabe M, Sato S, Toyooka H, Sagara E. Simultaneous determination of lidocaine and its diethyl-metabolites in plasma and its application to drug level monitoring in infants. J Appl Ther 1997: 2: 33-38.
6. Tucker GT, Mather LB. Clinical pharmacokinetics of local anaesthetics. Clin Pharmacokinet 1979: 4: 241-278.
7. Scott DB, Jebson PJR, Braid DP, Ortengren B, Frisch P. Factors affecting plasma levels of lignocaine and prilocaine. Br J Anaesth 1972: 44: 1040-1049.
8. Burm AGL, van Kleef JW, Gladines MPRR, Olthof G, Spierdijk J. Epidural anesthesia with lidocaine and bupivacaine: effects of epinephrine on the plasma concentration profiles. Anesth Analg 1986: 65: 1281-1284.
9. Kozody Z, Palahniuk R, Wade J, Gumming M, Pucci W. The effect of subarachnoid epinephrine and phenylephrine on spinal cord blood flow. Can Anaesth Soc J 1984: 31(5): 503-508.
10. Sharrock N, Go G, Mineo R. Effect of I.V. low-dose adrenaline and phenylephrine infusions on plasma concentrations of bupivacaine after lumbar extradural anaesthesia in elderly patients. Br J Anaesth 1991: 67: 694-698.
11. Blumer J, Strong JM, Atokinso JA. The convulsant potency of lidocaine and its N-dealkylated metabolites. J Pharmacol Exp Ther 1973: 186: 31-36.
12. Drayer DE, Lorenzo B, Werns S, Reidenberg MM. Plasma levels, protein binding, and elimination data of lidocaine and active metabolites in cardiac patients of various ages. Clin Pharmacol Ther 1983: 34: 14-22.
13. Strong JM, Atkinson AJ. Simultaneous measurement of plasma concentrations of lidocaine and its demethylated metabolite by mass fragmentography. Anal Chem 1972: 44: 2287-2290.
14. Nation RL, Triggs EJ, Selig M. Lignocaine kinetics in cardiac patients and aged subjects. Br J Clin Pharmacol 1977: 4: 349-448.
15. Miyabe M, Kakiuchi Y, Kihara S, Takahashi S, Kohda Y, Sato S, Toyooka H. The plasma concentration of lidocaine's principal metabolite increases during continuous epidural anesthesia in infants and children. Anesth Analg 1998: 87: 1056-1057.
16. Burney RG, Difazio CA, Peach KA, Petrie KA, Silvester MJ. Anti-arrhythmic effects of lidocaine metabolites. Am Heart J 1974: 88: 765-769.
17. Braid D, Scott D. Dosage of lignocaine in epidural block in relation to toxicity. Br J Anaeth 1966: 38: 596-602.
18. Goldfarb G, Debaene B, Ang E, Roulot D, Jolis P, Lebrec D. Hepatic blood flow in humans during isoflurane-N2O and halothane-N2O anesthesia. Anesth Analg 1990: 71: 349-353.
19. Gelman S, Fowler K, Smith L. Regional blood flow during isoflurane and halothane anesthesia. Anesth Analg 1984: 63: 557-565.
20. Conzen P, Vollmar B, Habazettl H, Frink E, Peter K, Messmer K. Systemic and regional hemodynamics of isoflurane and sevoflurane in rats. Anesth Analg 1992: 74: 79-88.
21. Frink EJ, Morgan S, Coetzee A, Conzen P, Brown BJ. The effects of sevoflurane, halothane, enflurane, and isoflurane on hepatic blood flow and oxygenation in chronically instrumented greyhound dogs. Anesthesiology 1992: 76: 85-90.
22. Hartman J, Pagel P, Proctor L, Kampine J, Schmeling W, Warltier D. Influence of desflurane, isoflurane and halothane on regional tissue perfusion in dogs. Can J Anaesth 1992: 39: 877-887.
23. Wood M, Wood A. Contrasting effects of halothane, isoflurane, and enflurane on in vivo drug metabolism in the rat. Anesth Analg 1984: 63: 709-714.
24. Rahman M, Fujii K, Kawamoto M, Yuge O. Contrasting effect of isoflurane on drug metabolism: decreased type I and increased type II substrate metabolism in guinea pig liver microsomes. J Appl Toxicol 1996: 16: 331-337.