Human dendritic cell mediated cytotoxicity against breast carcinoma cells in vitro

Journal of Leukocyte Biology

Volumn 72, Issue 2, 2002, Pages 312-320

  Manna, Partha P ^a   Mohanakumar, T ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; IFN ; LPS; TNF

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 15; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PRESENTING CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL; CELL ACTIVATION; CELL GROWTH; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; DENDRITIC CELL; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; IN VITRO STUDY; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; SUPERNATANT; T LYMPHOCYTE; TUMOR IMMUNITY;

ANTIBODIES, MONOCLONAL; APOPTOSIS; BREAST NEOPLASMS; CARCINOMA; CELL DIVISION; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-15; LIPOPOLYSACCHARIDES; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036697306     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Steinman, R. M. (1991) The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296.
2. Bancheraue, J., Steinman, R. M. (1998) Dendritic cells and the control of immunity. Nature 392, 245-252.
3. Hart, D. N. (1997) Dendritic cells: unique leukocyte population which control the primary immune response. Blood 90, 3245-3287.
4. Albert, M. L., Sauter, B., Bharadwaj, N. (1998) Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 392, 86-89.
5. Albert, M. L., Pearce, S. F., Francisco, L. M., Sauter, B., Roy, P., Silverstein, R. L., Bhardwaj, N. (1998) Immature dendritic cells phagocytose apoptotic cells via alphabeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188, 1359-1368.
6. Mayordomo, J. I., Zorina, T., Storkus, W. J., Zitovogel, L., Celluzi, C., Falo, L. D., Melief, C. J., Ildstad, S. T., Kast, W. M., Deleo, A. B. (1995) Bone marrow derived dendritic cells pulsed with synthetic tumor peptides elicit protective and therapeutic anti-tumor immunity. Nat. Med. 1, 1297-1302.
7. Schuler, G., Steinman, R. M. (1997) Dendritic cells as adjuvant for immune mediated resistance to tumors. J. Exp. Med. 186, 1183-1187.
8. Zitovagel, L., Mayordomo, J. I., Tjandrawan, T., DeLeo, A. B., Clarke, M. R., Lotze, M. T., Storkus, W. J. (1996) Therapy of murine tumors with tumor peptide pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines. J. Exp. Med. 183, 87-97.
9. Boczkowski, D., Nair, S. K., Snyder, D., Gilboa, E. (1996) Dendritic cells pulsed with RNA are potent antigen presenting cells in vitro and in vivo. J. Exp. Med. 184, 465-472.
10. Hsu, F. J., Benike, C., Fagnoni, F., Liles, T. M., Czerwinski, D., Taidi, B., Engleman, E. G., Levy, R. (1996) Vaccination of patients with B cell lymphoma using autologous antigen-pulsed dendritic cells. Nat. Med. 2, 52-58.
11. Nestle, F. O., Alijagic, S., Gillet, M., Sun, Y., Grable, S., Dummer, R., Burg, G., Schadendorf, D. (1998) Vaccination of melanoma patients with peptide-tumor lysate-pulsed dendritic cells. Nat. Med. 4, 328-332.
12. Gong, J., Chen, D., Kashiwaba, M., Kufe, D. (1997) Induction of antitumor immunity by immunization with fusions of dendritic and carcinoma cells. Nat. Med. 3, 558-561.
13. Kugler, A., Stuhler, G., Walden, P., Zoller, G., Zobwalski, A., Brossart, P., Trefzer, U., Ullrich, S., Muller, C. A., Becker, V., Gross, A. J., Hemmerlein, B., Kanz, L., Muller, G. A., Ringert, R. H. (2000) Regression of human metastatic renal carcinoma after vaccination with tumor cell-dendritic cell hybrids. Nat. Med. 6, 332-336.
14. Verhasselt, V., Buelens, C., Willems, F., De Groote, D., Haeffner-CavailIon, N., Goldman, M. (1997) Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. J. Immunol. 158, 2919-2925.
15. Becker, Y. (1992) Anticancer role of dendritic cells (DC) in human and experimental cancer. Anticancer Res. 12, 511-520.
16. Gabrilovich, D. I., Chen, H. L., Girgis, K. R., Cunningham, H. T., Meny, G. M., Nadaf, S., Kavanaugh, D., Carbone, D. P. (1996) Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2, 1096-1103.
17. Bell, D., Chomarat, P., Broyles, D., Netto, G., Harb, G. M., Lebecque, S., Valladeau, J., Davoust, J., Palucka, K. A., Bancereau, J. (1999) In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritoneal areas. J. Exp. Med. 190, 1417-1426.
18. Suss, G., Shortman, K. (1996) A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J. Exp. Med. 183, 1789-1796.
19. Fanger, N. A., Maliszewski, C. R., Schooley, K., Griffith, T. S. (1999) Human dendritic cell mediate cellular apoptosis via tumor necrosis factor related apoptosis inducing ligand (TRAIL). J. Exp. Med. 190, 1155-1164.
20. Josien, R., Heslan, M., Soulillou, J. P., Cuturi, M. C. (1997) Rat spleen dendritic cells express natural killer cell receptor protein 1 (NKR-P1) and have cytotoxic activity to select targets via a Ca2+-dependent mechanism. J. Exp. Med. 186, 467-472.
21. Chapoval, A. I., Tamada, K., Chen, L. (2000) In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells. Blood 95, 2346-2351.
22. Schroder, S., Schwarz, W., Rehpenninng, W., Loning, T., Bocker, W. (1988) Dendritic/Langerhans cells and prognosis in patients with papillary carcinoma. Immunohistochemical study of 106 thyroid neoplasm correlated to follow up data. Am. J. Clin. Pathol. 99, 295-300.
23. Bigotti, G., Coli, A., Castagnola, G. (1991) Distribution of Langerhans cells and HLA class II molecules in prostatic carcinomas of different histopathological grade. Prostate 19, 73-87.
24. Gabrilovitch, D. I., Corak, J., Ciernik, I. F., Kavanaugh, D., Carbone, D. P. (1997) Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin. Cancer Res. 3, 483-490.
25. Nair, S. K., Heiser, A., Boczkowski, D., Majumder, A., Naoe, M., Lebkowski, J. S., Vieweg, J., Gilboa, E. (2000) Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. Nat. Med. 6, 1011-1017.
26. Yang, R. B., Mark, M. R., Gray, A., Huang, A., Xie, M. H., Zhang, M., Goddard, A., Wood, W. I., Gurney, A. L., Godowski, P. J. (1998) Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 395, 284-288.