Expression of lymphocyte homing receptors α4β7 and MAdCAM-1 in young and old rats

Experimental Gerontology

Volumn 37, Issue 8-9, 2002, Pages 1089-1095

  Schmucker, Douglas L ^a,b,d   Owen, Trevor M ^a   Issekutz, Thomas B ^c   Gonzales, Loida ^a   Wang, Rose K ^a,b  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DALHOUSIE UNIVERSITY   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

4 7; Addressin; Immunoglobulin A; Integrin; Intestinal mucosal immunity; Lymphocyte homing; MAdCAM 1; Peyer's patches

Indexed keywords

ADDRESSIN; ALPHA4 INTEGRIN; HOMING RECEPTOR; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1;

AGING; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DENSITY; ENDOTHELIUM CELL; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; INTESTINE; LAMINA PROPRIA; MALE; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; SENESCENCE; STATISTICAL SIGNIFICANCE; VASCULAR ENDOTHELIUM;

AGING; ANIMALS; CELL MOVEMENT; FLOW CYTOMETRY; IMMUNOGLOBULIN A; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; INTEGRINS; LEUKOCYTES, MONONUCLEAR; MALE; MUCOPROTEINS; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0036696553     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(02)00065-7     Document Type: Article

References (15)

1. Farstad I.N., Halstensen T.S., Kvale D., Fausa O., Brandtzaeg P. Topographic distribution of homing receptors on B and T cells in human gut-associated lymphoid tissue: relation of L-selectin and integrin α4β7 to naïve and memory phenotypes. Am. J. Pathol. 150:1997;187-199.
2. Kantele A., Kantele J.M., Savilahti E., Westerholm M., Arvilommi H., Lazarovits A., Butcher E.C., Makela P.H. Homing potentials of circulating lymphocytes in humans depend on the site of activation: oral, but not parenteral, typhoid vaccination induces circulating antibody-secreting cells that all bear homing receptors directing them to the gut. J. Immunol. 158:1997;574-579.
3. Lynch R.G., Sandor M., Waldschmidt T.J. Receptors for IgA and IgE on T and B lymphocytes: development, regulation and function. Res. Immunol. 141:1990;241-248.
4. Ogino T., Komoto S., Hara Y., Watanabe C., Koseki S., Hokari R., Nagata H., Hachimura S., Kaminogawa S., Ishii H. Senescence-associated decline of lymphocyte migration in gut-associated lymphoid tissues of rat small intestine. Gastroenterology. 120:2001;A-672 abst.
5. Palecanda A., Marshall J.S., Li X., Briskin M.J., Issekutz T.B. Selective antibody blockade of lymphocyte migration to mucosal sites and mast cell adhesion. J. Leukoc. Biol. 65:1999;649-657.
6. Sackstein R., Meng L., Xu X.M. Evidence of post-transcriptional regulation of L-selectin gene expression in rat lymphoid cells. Immunology. 85:1995;198-204.
7. Salmi M., Alanen K., Grenman S., Briskin M., Butcher E.C., Jalkanen S. Immune cell trafficking in uterus and early life is dominated by the mucosal addressin MAsCAM-1 in humans. Gastroenterology. 121:2001;853-864.
8. Sandor M., Ibraghimov A., Rosenberg M.G., Teeraratkul P., Lynch R.G. Expression of IgA and IgM Fc receptors on murine T lymphocytes. Immunol. Res. 11:1992;169-180.
9. Schmucker D.L., Owen R.L. Aging and the gastrointestinal mucosal immune response. Curr. Opin. Gastroenterol. 13:1997;534-541.
10. Schmucker D.L., Daniels C.K., Wang R.K., Smith K. Mucosal immune response to cholera toxin in aging rats. I. Antibody and antibody-containing cell response. Immunology. 64:1988;691-695.
11. Schmucker D.L., Heyworth M.F., Owen R.L., Daniels C.K. Impact of aging on gastrointestinal mucosal immunity. Digest. Dis. Sci. 41:1996;1183-1193.
12. Steeber D.A., Green N.E., Sato S., Tedder T.F. Lymphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system. J. Immunol. 157:1996;1096-1106.
13. Takeuchi M., Baichwal V. Induction of the gene encoding mucosal vascular addressin cell adhesion molecule 1 by tumor necrosis factor α is mediated by NF-κB proteins. Proc. Natl Acad. Sci. (USA). 92:1995;3561-3565.
14. Taylor L.D., Daniels C.K., Schmucker D.L. Aging compromises gastrointestinal mucosal immune response in the rhesus monkey. Immunology. 75:1992;614-618.
15. Thoreux K., Owen R.L., Schmucker D.L. Intestinal lymphocyte number, migration and antibody secretion in young and old rats. Immunology. 101:2000;161-167.