Study on the effects of p53 deletion and mutation on malignant phenotype of human lung cancer cell line

Chinese Journal of Lung Cancer

Volumn 5, Issue 4, 2002, Pages 245-249

  Wang, Hui ^a   Lai, Baitang ^a   Li, Jinzhao ^a   Yang, Xuehui ^a   Zhang, Chunyan ^a   Yue, Wentao ^a   Zhang, Hongtao ^a   Li, Xi ^a   Zhan, Xiuping ^a   Wang, Yue ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Antisense p53; Colony formation; Sense p53; Transfection; Transplantatio

Indexed keywords

ANTIBODY; GREEN FLUORESCENT PROTEIN; PROTEIN P53; PROTEIN P53 ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE G1 PHASE; CLONOGENIC ASSAY; COLONY FORMATION; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; GENETIC CODE; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG CANCER; LUNG TRANSPLANTATION; NUDE MOUSE; PHENOTYPE; PLASMID; POLYMERASE CHAIN REACTION; TUMOR GROWTH;

EID: 0036691099     PISSN: 10093419     EISSN: 19996187     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. p53, the cellular gatekeeper for growth and division
2. p53 mutations in human lung tumors
3. Molecular epidemiology of human cancer: Contribution of mutation spectra studies of tumor suppressor genes
4. Gain of function mutations in p53
5. Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model
6. Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions
7. Pharmacological rescue of mutant p53 conformation and function
8. Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain
9. Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations
10. Oncogenic mutation of the p53 tumor suppressor: The demons of the guardian of the genome