Structure-activity relationships of 6-nitroquinazolines: Dual-acting compounds with inhibitory activities toward both TNF- α production and T cell proliferation

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 8, 2002, Pages 1073-1080

  Tobe, Masanori ^a   Isobe, Yoshiaki ^a   Tomizawa, Hideyuki ^a   Nagasaki, Takahiro ^a   Obara, Fumihiro ^a   Matsumoto, Mitsuhiro ^a   Hayashi, Hideya ^a  

^a JAPAN ENERGY CORPORATION   (Japan)

Author keywords

6 nitroquinazoline; T cell proliferation; TNF production

Indexed keywords

4 (3,4 DIFLUOROBENZYLAMINO) 6 NITRO 7 (1 PIPERAZINO)QUINAZOLINE; 4 (4 FLUOROBENZYLAMINO) 6 NITRO 7 (1 PIPERAZINO)QUINAZOLINE; ANTIINFLAMMATORY AGENT; PIPERAZINE DERIVATIVE; QUINAZOLINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; GROWTH INHIBITOR; NITROQUINOLINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; LYMPHOCYTE ACTIVATION; METABOLISM; T LYMPHOCYTE;

ANIMALS; DRUG EVALUATION, PRECLINICAL; GROWTH INHIBITORS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; NITROQUINOLINES; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036690264     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.1073     Document Type: Article

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