Asymmetric synthesis of a selective endothelin a receptor antagonist

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 8, 2002, Pages 1066-1072

  Kato, Yoshiaki ^a   Niiyama, Kenji ^b   Jona, Hideki ^b   Okada, Shigemitsu ^a   Akao, Atsushi ^a   Hiraga, Shouichi ^a   Tsuchiya, Yoshimi ^b   Tomimoto, Koji ^a   Mase, Toshiaki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Asymmetric conjugate addition; Endothelin antagonist; Oxazoline; Phosphate mediated cyclization; Thiomicamine

Indexed keywords

ENDOTHELIN A RECEPTOR ANTAGONIST; FERROCENE DERIVATIVE; OXAZOLINE DERIVATIVE; PHENETHYLAMINE DERIVATIVE; ENDOTHELIN A RECEPTOR; ENDOTHELIN RECEPTOR; LITHIUM DERIVATIVE; OXAZOLE DERIVATIVE; OXAZOLIDINE;

ADDITION REACTION; ARTICLE; ASYMMETRIC SYNTHESIS; CARBONYLATION; CATALYSIS; CRYSTALLIZATION; CYCLIZATION; DEPROTECTION REACTION; DIASTEREOISOMER; DRUG HYDROLYSIS; DRUG PURIFICATION; ENANTIOMER; REDUCTION KINETICS; CONFORMATION; DRUG ANTAGONISM; METHODOLOGY; PHARMACEUTICS; SYNTHESIS;

LITHIUM COMPOUNDS; MOLECULAR CONFORMATION; OXAZOLES; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; TECHNOLOGY, PHARMACEUTICAL;

EID: 0036689112     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.1066     Document Type: Article

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