Detection of antibodies to human immunodeficiency virus (HIV) that recognize conformational epitopes of glycoproteins 160 and 41 often allows for early diagnosis of HIV infection

Journal of Infectious Diseases

Volumn 186, Issue 3, 2002, Pages 321-331

  Chen, Jianmin ^a   Wang, Liqiang ^b   Chen, Jenny J Y ^b   Sahu, Gautam K ^a   Tyring, Stephen ^a,d   Ramsey, Keith ^e   Indrikovs, Alexander J ^b   Petersen, John R ^b   Paar, David ^c   Cloyd, Miles W ^a,b  

^a Microbiology and Immunology   (United States)

^b Departments of Pathology   (United States)

^c Internal Medicine   (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^e UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 160; GLYCOPROTEIN GP 41; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

ANTIBODY DETECTION; ANTIGEN RECOGNITION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EARLY DIAGNOSIS; ENZYME IMMUNOASSAY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BLOTTING, WESTERN; DNA, VIRAL; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HIV; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP160; HIV ENVELOPE PROTEIN GP41; HIV INFECTIONS; HUMANS; IMMUNOENZYME TECHNIQUES; PROTEIN CONFORMATION; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0036681672     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/341661     Document Type: Article

References (76)

1. Serologic testing for human immunodeficiency virus antibodies
2. Whose blood is safer? The effect of the stage of the epidemic on screening for HIV
3. Silent HIV infection
4. Delayed HIV sero-conversion in an Indian male
5. Interpretation of indeterminate HIV serology results in an incarcerated population
6. Increased sensitivity of HIV-1 antibody detection
7. Early diagnosis of primary HIV infections: Using a combined screening test (p24 antigen and anti-HIV antibodies)
8. Two successive HIV contaminations from subjects in the window period
9. Evaluation of screened blood donations for human immunodeficiency virus type 1 infection by culture and DNA amplification of pooled cells
10. Transmission of human immunodeficiency virus type 1 from a seronegative organ and tissue donor
11. Safety of the blood supply in the United States: Opportunities and controversies
12. Time course of detection of viral and serologic markers preceding human immunodeficiency virus type 1 seroconversion: Implications for screening of blood and tissue donors
13. Prevention of transmission of HIV by organ and tissue transplantation: HIV testing protocol and a proposal for recommendations concerning donor selection
14. HIV epidemic in Punjab, India: Time trends over a decade
15. HIV infection in dialysis centers in Italy: A nationwide multicenter study
16. New developments in serologic screening of corneal donors for HIV-1 and hepatitis B virus infections
17. Diagnostic testing for HIV type 1 RNA in seronegative blood
18. Viral RNA in the resolution of human immunodeficiency virus type 1 diagnostic serology
19. Silent human immunodeficiency virus type 1 infection: A rare occurrence in a high-risk heterosexual population
20. Resolution of infection status of human immunodeficiency virus (HIV)-seroindeterminate donors and high-risk seronegative individuals with polymerase chain reaction and virus culture: Absence of persistent silent HIV type 1 infection in a high-prevalence area
21. Low prevalence of HIV in high-risk seronegative homosexual men evidenced by virus culture and polymerase chain reaction
22. Failure to detect silent HIV infection by polymerase chain reaction in subjects at risk for heterosexually transmitted HIV type 1 infection
23. Lack of detection of human immunodeficiency virus in persistently seronegative homosexual men with high or medium risks for infection
24. HIV-1 PCR and isolation in seroconverting and seronegative homosexual men: Absence of long-term immunosilent infection
25. Absence of chronic human immunodeficiency virus infection without seroconversion in intravenous drug users: A prospective and retrospective study
26. Human immunodeficiency virus-infected individuals contain provirus in small numbers of peripheral mononuclear cells and at low copy numbers
27. Low human immunodeficiency virus type 1 (HIV-1) DNA burden as a major cause for failure to detect HIV-1 DNA in clinical specimens by PCR
28. Simultaneous amplification of multiple HIV-1 DNA sequences from clinical specimens by using nested-primer polymerase chain reaction
29. Polymerase chain reaction and HIV
30. Exposure to human immunodeficiency virus (HIV) type 1 indicated by HIV-specific T helper cell responses before detection of infection by polymerase chain reaction and serum antibodies
31. An immunoendocrinological hypothesis of HIV infection
32. Polyclonal B-cell activation reveals antibodies against human immunodeficiency virus type 1 (HIV-1) in HIV-1-seronegative individuals
33. Human immunodeficiency virus infection elicits early antibody not detected by standard tests: Implications for diagnostics and viral immunology
34. Fourth-generation enzyme-linked immunosorbent assay for the simultaneous detection of human immunodeficiency virus antigen and antibody
35. Reduction of diagnostic window by new fourth-generation human immunodeficiency virus screening assays
36. Improved performance of seroconversion with a 4th generation HIV antigen/antibody assay
37. Strongly enhanced sensitivity of a direct anti-HIV-1/-2 assay in seroconversion by incorporation of HIV p24 ag detection: A new generation vironostika HIV Uni-Form II
38. Reduction of the diagnostic window with a new combined p24 antigen and human immunodeficiency virus antibody screening assay
39. Shortening of the diagnostic window with a new combined HIV p24 antigen and anti-HIV-1/2/O screening test
40. A contained indirect viable-cell membrane immunofluorescence microassay for surface antigen analysis of cells infected with hazardous viruses
41. Heterogeneity of human immunodeficiency virus cell-associated antigens and demonstration of virus type-specificities of human antibody responses
42. Spectrum of biological properties of human immunodeficieney virus (HIV-1) isolates
43. Development of T cell lines expressing functional HIV-1 envelope glycoproteins for evaluation of immune responses in HIV-infected individuals
44. Epitopes on protein antigens: Misconceptions and realities
45. +T cells
46. An immunologic approach to the conformational equilibria of polypeptides
47. Quantitative image analysis of HIV-1 infection in lymphoid tissue
48. The lymphocyte-dendritic cell system
49. Dendritic cells and the control of immunity
50. MCF-specific murine monoclonal antibodies made against AKR-247 MCF virus recognize a unique determinant associated with the gp70-p-15(E) complex
51. Characterization of monoclonal antibodies reactive with murine leukemia viruses: Use in analysis of strains of Friend MCF and Friend ecotropic murine leukemia virus
52. Monoclonal antibodies to xenotropic and MCF murine leukemia viruses derived during the graft-versus-host reaction
53. Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods
54. Proviral sequences detection of human immunodefieiency virus in seronegative subjects by polymerase chain reaction
55. Detection of human immunodeficiency virus type 1 by PCR before seroconversion in high-risk individuals who remain seronegative for prolonged periods
56. Duration of human immunodeficiency virus infection before detection of antibody
57. Identification of HIV-infected seronegative individuals by a direct diagnostic test based on hybridisation to amplified viral DNA
58. DNA amplification of HIV-1 in seropositive individuals and in seronegative at-risk individuals
59. Human T-lymphotropic virus type III in high-risk, antibody-negative homosexual men
60. Persistence of HIV-1 silent infection in seronegative subjects at high risk
61. Long latency precedes overt seroconversion in sexually transmitted human-immunodeficiency-virus infection
62. HTLV-III in symptom-free seronegative persons
63. Human immunodeficieney virus type 1 (HIV-1) infection a median of 18 months before a diagnostic Western blot: Evidence from a cohort of homosexual men
64. HIV-1 causing AIDS and death in a seronegative individual
65. Transmission of retroviruses by transfusion of screened blood in patients undergoing cardiac surgery
66. Transfusion-associated (T-A) AIDS in the United States
67. Transmission of human immunodeficiency virus (HIV) by blood transfusions screened as negative for HIV antibody
68. Plasma viraemia in seronegative HIV-1-infected individuals
69. Failure of routine HIV-1 tests in a case involving transmission with preseroconversion blood components during the infectious window period
70. A prospective study of the risk of transfusion-acquired viral infections
71. Absence of prolonged immunosilent infection with human immunodeficieney virus in individuals with high-risk behaviors
72. Transmission of HIV-1 from seronegative but PCR-positive blood donor
73. HIV-specific T-helper activity in seronegative health care workers exposed to contaminated blood
74. Markers of HIV infection prior to IgG antibody seropositivity
75. Antibodies to the nef protein and to nef peptides in HIV-1-infected seronegative individuals