Pronounced radiosensitization of cultured human cancer cells by COX inhibitor under acidic microenvironment

International Journal of Radiation Oncology Biology Physics

Volumn 53, Issue 5, 2002, Pages 1314-1318

  Shah, Tushar ^a   Ryu, Samuel ^a   Lee, Ho Jun ^a   Brown, Stephen ^a   Kim, Jae Ho ^a  

^a HENRY FORD HOSPITAL   (United States)

Author keywords

Acidic microenvironment; COX inhibitors; Radiosensitization

Indexed keywords

CELL CULTURE; ENZYME INHIBITION; IRRADIATION; PH EFFECTS; TOXICITY;

RADIOSENSITIZATION;

CELLS;

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; IBUPROFEN;

ACIDITY; ARTICLE; CANCER CELL; CELL KILLING; CELL SURVIVAL; CLONOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; MICROENVIRONMENT; PH; PRIORITY JOURNAL; RADIATION DOSE; RADIATION RESPONSE; RADIOSENSITIZATION;

CELL SURVIVAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN-ION CONCENTRATION; IBUPROFEN; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; RADIATION-SENSITIZING AGENTS; SULFONAMIDES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0036680290     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(02)02889-4     Document Type: Article

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