Development of a capillary gas chromatographic method with flame ionisation detection for the simultaneous determination of sildenafil and its N-demethylated metabolite in biological fluids

Journal of Separation Science

Volumn 25, Issue 12, 2002, Pages 767-772

  Berzas Nevado, J J ^a   Villasenor Llerena M J ^a   Contento Salcedo, A M ^a   Flores, Juana Rodríguez ^a  

^a UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

Author keywords

Biological sample analysis; Capillary gas chromatography; Flame ionisation detection; Mass spectrometry; Sildenafil; UK 103,320

Indexed keywords

EXTRACTION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES;

FLAME IONISATION DETECTOR;

SEPARATION;

1 [[3 (6,7 DIHYDRO 1 METHYL 7 OXO 3 PROPYL 1H PYRAZOLO[4,3 D]PYRIMIDIN 5 YL) 4 ETHOXYPHENYL]SULFONYL]PIPERAZINE; DRUG METABOLITE; SILDENAFIL; UK 103320; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; BODY FLUID; CAPILLARY GAS CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); DEMETHYLATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; HUMAN; MALE; MASS SPECTROMETRY; MOLECULAR STABILITY; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TIME; VALIDATION PROCESS;

EID: 0036670539     PISSN: 16159306     EISSN: None     Source Type: Journal    
DOI: 10.1002/1615-9314(20020801)25:12<767::AID-JSSC767>3.0.CO;2-0     Document Type: Article

References (16)